Psychiatric comorbidity in methamphetamine dependence
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The primary aim of the present study was to assess the prevalence of psychiatric comorbidity in a large sample of methamphetamine (MA)-dependent subjects using a validated structured clinical interview, without limitation to sexual orientation or participation in a treatment program. The secondary aim was to assess whether the prevalence of psychiatric comorbidities varied by gender. Structured clinical interviews (SCIDs) were administered to 189 MA-dependent subjects and lifetime prevalence of DSM-IV diagnoses was assessed. Across the sample, 28.6% had primary psychotic disorders, 23.8% of which were substance-induced; 13.2% had MA-induced delusional disorders and 11.1% had MA-induced hallucinations. A substantial number of lifetime mood disorders were identified that were not substance-induced (32.3%), whereas 14.8% had mood disorders induced by substances, and 10.6% had mood disorders induced by amphetamines. Of all participants, 26.5% had anxiety disorders and 3.7% had a substance-induced anxiety disorder, all of which were induced by MA. Male subjects reported a higher percentage of MA-induced delusions compared to female abusers. Given the impact of MA psychosis and other drug-induced symptoms on hospitals and mental health services, the description and characterization of comorbid psychiatric symptoms associated with MA use is of paramount importance.
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Methamphetamine use is highly comorbid with anxiety disorders and psychological interventions are currently the front-line treatment for stimulants, yet studies investigating the effectiveness of psychological interventions among patients with comorbid anxiety disorders remain under researched.
“Methamphetamine use is highly comorbid with anxiety disorders and psychological interventions are currently the front-line treatment for stimulants, yet studies investigating the effectiveness of psychological interventions among patients with comorbid anxiety disorders remain under researched.(Salo et al., 2011; Stuart et al., 2020)”
From A systematic review and meta-analysis of psychosocial interventions for persons with comorbid anxiety and substance use disorders (2024) · cites this paper as Salo et al., 2011
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- Authors
- Salo, R., Flower, K., Kielstein, A., Leamon, M. H., Nordahl, T. E., & Galloway, G. P.
- Affiliations
- University of California, Davis (US)
- California Pacific Medical Center (US)
- Corresponding author
- Galloway, Gantt P.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 186
- Issue
- 2-3
- Pages
- 356-361
- ISSN
- 0165-1781 (ISSN-L)
- PMC
- PMC3058719
- OpenAlex
- W2022547601
- Cited by
- 151
- References
- 35
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 13 · 2023: 10 · 2022: 15 · 2021: 7 · 2020: 10 · 2019: 11 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 15 · 2012: 4
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health (5r01da010739-03)
- National Institute on Drug Abuse (DA16329, DA 10641, R21DA014359, R21DA016329, DA14359, R01DA010641, DA10739, K01DA016293)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- methamphetamine dependence, psychiatric comorbidity, drug-induced psychosis, delusional disorder, hallucinations, mood disorders, anxiety disorders, gender differences, lifetime prevalence, DSM-IV diagnosis
- MeSH terms
- Adolescent, Adult, Aged, Mental Disorders, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Severity of Illness Index, Comorbidity, Amphetamine-Related Disorders, Young Adult
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