Cited by 89Schizophrenia research and treatmentFatty Acid Research and HealthLipid Membrane Structure and Behavior

Impaired Plasmalogens in Patients with Schizophrenia

Kaddurah-Daouk, Rima, McEvoy, Joseph, Baillie, Rebecca, Zhu, Hongjie, K. Yao, Jeffrey, Nimgaonkar, Vishwajit L., Buckley, Peter F., Keshavan, Matcheri S. +2 more·2012·Psychiatry Research

Abstract

Plasmalogens are a subclass of glycerophospholipids and ubiquitous constituents of cellular membranes and serum lipoproteins. Several neurological disorders show decreased level of plasmogens. An earlier study found differences in plasma phospholipids between unmedicated patients with schizophrenia and matched healthy control subjects. We here report a comparison of plasma plasmalogen levels across 20 drug-naïve patients experiencing first psychotic episodes, 20 recently unmedicated patients experiencing psychotic relapses after failing to comply with prescribed medications, and 17 matched healthy control subjects. Multiple plasma phosphatidylcholine and phosphatidylethanolamine plasmalogen levels were significantly lower in first episode patients and patients with recurrent disease compared to healthy controls. Reduced plasmalogen levels appear to be a trait evident at the onset of psychotic illness and after multiple psychotic relapses. It is implied that reductions in plasmalogen levels are not related to antipsychotic treatment but due to the illness itself. Reduced plasmalogen levels suggest impairments in membrane structure and function in patients with schizophrenia that might happen early in development. This may serve as a clue to the neurobiology of schizophrenia and should be studied as a potential biomarker for individuals at risk for schizophrenia.

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Crossref · 10.1016/j.psychres.2012.02.019

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Authors
Kaddurah-Daouk, R., McEvoy, J., Baillie, R., Zhu, H., K. Yao, J., Nimgaonkar, V. L., Buckley, P. F., Keshavan, M. S., Georgiades, A., & Nasrallah, H. A.
Affiliations
  • Duke Medical Center (US)
  • Rosa (United States) (US)
  • North Carolina State University (US)
  • University of Pittsburgh (US)
  • Augusta University (US)
  • Harvard University (US)
  • University of Cincinnati (US)
Corresponding author
Kaddurah-Daouk, Rima
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2012-08
Volume
198
Issue
3
Pages
347-352
ISSN
0165-1781 (ISSN-L)
OpenAlex
W2055974481
Cited by
89
References
67
Citations by year
2026: 4 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 5 · 2013: 3
FWCI
3.88
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
plasmalogens, schizophrenia, plasma phospholipids, first-episode psychosis, psychotic relapse, medication non-adherence, drug-naive patients, membrane structure, biomarkers, neurobiology of schizophrenia
MeSH terms
Adult, Age Factors, Chronic Disease, Female, Humans, Male, Phosphatidylcholines, Phosphatidylethanolamines, Plasmalogens, Psychiatric Status Rating Scales, Schizophrenia, Sex Characteristics, Biomarkers, Body Mass Index, Case-Control Studies, Metabolomics

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