Impaired Plasmalogens in Patients with Schizophrenia
Abstract
Plasmalogens are a subclass of glycerophospholipids and ubiquitous constituents of cellular membranes and serum lipoproteins. Several neurological disorders show decreased level of plasmogens. An earlier study found differences in plasma phospholipids between unmedicated patients with schizophrenia and matched healthy control subjects. We here report a comparison of plasma plasmalogen levels across 20 drug-naïve patients experiencing first psychotic episodes, 20 recently unmedicated patients experiencing psychotic relapses after failing to comply with prescribed medications, and 17 matched healthy control subjects. Multiple plasma phosphatidylcholine and phosphatidylethanolamine plasmalogen levels were significantly lower in first episode patients and patients with recurrent disease compared to healthy controls. Reduced plasmalogen levels appear to be a trait evident at the onset of psychotic illness and after multiple psychotic relapses. It is implied that reductions in plasmalogen levels are not related to antipsychotic treatment but due to the illness itself. Reduced plasmalogen levels suggest impairments in membrane structure and function in patients with schizophrenia that might happen early in development. This may serve as a clue to the neurobiology of schizophrenia and should be studied as a potential biomarker for individuals at risk for schizophrenia.
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The levels of PC and PE did not differ significantly in FEP patients and medicated patients.
“The levels of PC and PE did not differ significantly in FEP patients and medicated patients [53,54].”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [54]
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- Authors
- Kaddurah-Daouk, R., McEvoy, J., Baillie, R., Zhu, H., K. Yao, J., Nimgaonkar, V. L., Buckley, P. F., Keshavan, M. S., Georgiades, A., & Nasrallah, H. A.
- Affiliations
- Duke Medical Center (US)
- Rosa (United States) (US)
- North Carolina State University (US)
- University of Pittsburgh (US)
- Augusta University (US)
- Harvard University (US)
- University of Cincinnati (US)
- Corresponding author
- Kaddurah-Daouk, Rima
- ORCID
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 198
- Issue
- 3
- Pages
- 347-352
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2055974481
- Cited by
- 89
- References
- 67
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 5 · 2013: 3
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- plasmalogens, schizophrenia, plasma phospholipids, first-episode psychosis, psychotic relapse, medication non-adherence, drug-naive patients, membrane structure, biomarkers, neurobiology of schizophrenia
- MeSH terms
- Adult, Age Factors, Chronic Disease, Female, Humans, Male, Phosphatidylcholines, Phosphatidylethanolamines, Plasmalogens, Psychiatric Status Rating Scales, Schizophrenia, Sex Characteristics, Biomarkers, Body Mass Index, Case-Control Studies, Metabolomics
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