Cited by 183Alzheimer's disease research and treatmentsSphingolipid Metabolism and SignalingDementia and Cognitive Impairment Research

Lipid Alterations in the Earliest Clinically Recognizable Stage of Alzheimers Disease: Implication of the Role of Lipids in the Pathogenesis of Alzheimers Disease

Han, Xianlin·2005·Current Alzheimer Research

Abstract

Lipids have many important yet distinct functions in cellular homeostasis such as forming an impermeable barrier separating intracellular and extracellular compartments, providing a matrix for the appropriate interactions of membrane-associated proteins, and serving as storage reservoirs for biologically active second messengers. Alterations in cellular lipids may therefore result in abnormal cellular functions. This review summarizes the results from the examination of lipid alterations in Alzheimer's disease (AD). In addition to the effects of cholesterol on AD, substantial depletions of plasmalogen and sulfatide as well as dramatic increases in ceramide are specifically manifested at the earliest clinically recognizable stage of AD. The potential mechanism(s) underlying these changes and the potential consequences of these changes in neuronal function and in AD development are also discussed. Collectively, this review will provide an overview of the lipid alterations in Alzheimer's disease and the relationship of these lipid alterations with the development of AD pathogenesis.

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Crossref · 10.2174/1567205052772786

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145 of 145 references verified0 citation errors · 0 not checkable

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  • Previous studies have shown that the lipids that were or tended to be decreased in PLCG2 KO mice (cerebrosides, sulfatides and plasmalogens) have been also reported to be decreased early in AD.

    “Notably, previous studies have shown that the lipids that were or tended to be decreased in PLCG2 KO mice (cerebrosides, sulfatides and plasmalogens) have been also reported to be decreased early in AD (39–41).”

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Authors
Han, X.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Han, Xianlin
Venue
Current Alzheimer Research
Published
2005-01-01
Volume
2
Issue
1
Pages
65-77
ISSN
1567-2050 (ISSN-L)
OpenAlex
W1986724957
Cited by
183
References
146
Citations by year
2026: 1 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 12 · 2020: 8 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 12
FWCI
5.42
Type
journal article
Language
en
Open access
closed
Locations
  • Current Alzheimer Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (P01 AG0 3991, P01AG003991)
  • National Heart, Lung, and Blood Institute (P01HL57278, P01HL057278)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, lipid changes, cholesterol, plasmalogens, sulfatide, ceramide, Alzheimer's disease pathogenesis, neuronal function, membrane lipids
MeSH terms
Alzheimer Disease, Apolipoproteins E, Ceramides, Cholesterol, Humans, Plasmalogens, Sulfoglycosphingolipids

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