Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome
Open accessAbstract
Low-frequency repetitive transcranial magnetic stimulation (rTMS) to supplementary motor area (SMA) showed clinical benefit in obsessive-compulsive disorder (OCD). Here we tested whether clinical improvement was associated with enhanced cortical inhibition as measured by single and paired-pulse TMS variables. In 18 OCD patients receiving 4 weeks of either active or sham rTMS in a double-blind randomized trial, we assessed bilateral resting and active motor thresholds (RMT and AMT), cortical silent period (CSP), short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF). We tested correlations between changes in Yale-Brown Obsessive Compulsive Scale-Self-report (Y-BOCS-SR), Clinical Global Impression-Severity subscale (CGI-S) and cortical excitability measures. Active rTMS increased right hemisphere RMT whose change correlated with Y-BOCS-SR improvement. Baseline RMT hemispheric asymmetry, defined as the difference between left and right hemispheres RMT, and its normalization after active rTMS correlated with Y-BOCS-SR and CGI-S improvements. Active rTMS also increased right hemisphere SICI whose change correlated with Y-BOCS-SR and CGI-S at week 4, and with normalization of baseline RMT hemispheric asymmetry. Treatment-induced changes in cortical excitability measures are consistent with an inhibitory action of SMA rTMS on dysfunctional motor circuits in OCD. Correlations of neurophysiology measures with therapeutic outcome are supportive of the role of SMA in the modulation of OCD symptoms.
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Multiple studies, including two sham-controlled trials, have applied low-frequency TMS to the SMA and reported promising results.
“Based on these findings, multiple studies have applied low frequency TMS in SMA to reverse its hyperactivity with promising results, including two sham-controlled trials 135,136.”
From DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS: Review: Dissecting OCD Circuits: Animals to Treatments (2015) · cites this paper as [135]
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Cites
(1976) · Medical Entomology and Zoology · Cited by 8,899 · see citing works
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712 · see citing works
Rossi, S., Hallett, M., Rossini, P. M., & Pascual-Leone, A. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.08.016 · Cited by 5,367 · see citing works
Self-citationCorticocortical inhibition in human motor cortex.
Kujirai, T., Caramia, M. D., Rothwell, J. C., Day, B. L., Thompson, P. D., Ferbert, A., Wroe, S. J., Asselman, P., & MARSDEN, C. D. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019912 · Cited by 3,132 · see citing works
Structured clinical interview for DSM-IV axis I disorders : SCID-I : clinical version : scoresheet
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1997) · American Psychiatric Press eBooks · Cited by 3,101 · see citing works
Rossini, P. M., Barker, A. T., Berardelli, A., Caramia, M. D., Caruso, G., Cracco, R. Q., Dimitrijević, M. R., Hallett, M., Katayama, Y., Lücking, C. H., et al. (1994) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(94)90029-9 · Cited by 3,030 · see citing works
The Yale-Brown Obsessive Compulsive Scale: II. Validity
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110054008 · Cited by 2,799 · see citing works
The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency
Kim, S. W., Dysken, M. W., Pheley, A. M., & Hoover, K. M. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90039-6 · Cited by 2,361 · see citing works
Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation
Chen, R., Classen, J., Gerloff, C., Celnik, P., Wassermann, E. M., Hallett, M., & Cohen, L. G. (1997) · Neurology · doi:10.1212/wnl.48.5.1398 · Cited by 2,128 · cited 2× · see citing works
“Given this evidence of deficient motor inhibitory control in OCD, the use of low-frequency repetitive TMS (rTMS) to enhance inhibition in motor circuits (Chen et al., 1997) may be a fruitful avenue to explore as a putative treatment.”
BackgroundMenzies, L., Chamberlain, S. R., Laird, A. R., Thelen, S. M., Sahakian, B. J., & Bullmore, E. T. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.09.005 · Cited by 1,190 · see citing works
Picard, N., & Strick, P. L. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(01)00266-5 · Cited by 1,184 · see citing works
Ziemann, U., Lönnecker, S., Steinhoff, B. J., & Paulus, W. (1996) · Annals of Neurology · doi:10.1002/ana.410400306 · Cited by 1,136 · see citing works
Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder
Saxena, S., & Rauch, S. L. (2000) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70181-7 · Cited by 840 · see citing works
Chamberlain, S. R., Blackwell, A. D., Fineberg, N. A., Robbins, T. W., & Sahakian, B. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.11.006 · Cited by 830 · see citing works
The effect of lorazepam on the motor cortical excitability in man
Ziemann, U., L�nnecker, S., Steinhoff, B., & Paulus, W. (1996) · Experimental Brain Research · doi:10.1007/bf00228633 · Cited by 793 · see citing works
Functional organization of human supplementary motor cortex studied by electrical stimulation
Fried, I., Katz, A., McCarthy, G., Sass, K., Williamson, P., Spencer, S., & Spencer, D. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03656.1991 · Cited by 791 · see citing works
Neurobiological Mechanisms of the Placebo Effect
Benedetti, F., Mayberg, H., Wager, T., Stohler, C., & Zubieta, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3458-05.2005 · Cited by 771 · see citing works
Altered corticostriatal functional connectivity in obsessive-compulsive disorder
Harrison, B. J., Soriano-Mas, C., Pujol, J., Ortiz, H., López-Solà, M., Hernández-Ribas, R., Deus, J., Alonso, P., Yücel, M., Pantelis, C., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.152 · Cited by 571 · see citing works
The Yale-Brown obsessive compulsive scale: Interview versus self-report
Steketee, G., Frost, R., & Bogart, K. (1996) · Behaviour Research and Therapy · doi:10.1016/0005-7967(96)00036-8 · Cited by 477 · see citing works
Dextromethorphan decreases the excitability of the human motor cortex
Ziemann, U., Chen, R., Cohen, L. G., & Hallett, M. (1998) · Neurology · doi:10.1212/wnl.51.5.1320 · Cited by 422 · see citing works
Frontal-striatal dysfunction during planning in obsessive-compulsive disorder
van den Heuvel, O. A., Veltman, D. J., Groenewegen, H. J., Cath, D. C., van Balkom, A. J. L. M., van Hartskamp, J., Barkhof, F., & van Dyck, R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.301 · Cited by 417 · see citing works
Two phases of intracortical inhibition revealed by transcranial magnetic threshold tracking
Fisher, R. J., Nakamura, Y., Bestmann, S., Rothwell, J. C., & Bostock, H. (2002) · Experimental Brain Research · doi:10.1007/s00221-001-0988-2 · Cited by 403 · see citing works
Mantovani, A., Lisanby, S. H., Pieraccini, F., Ulivelli, M., Castrogiovanni, P., & Rossi, S. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005729 · Cited by 334 · see citing works
Self-citationAltered cortical excitability in obsessive–compulsive disorder
Greenberg, B. D., Ziemann, U., Corá-Locatelli, G., Harmon, A., Murphy, D. L., Keel, J. C., & Wassermann, E. M. (2000) · Neurology · doi:10.1212/wnl.54.1.142 · Cited by 285 · see citing works
Mantovani, A., Simpson, H. B., Fallon, B. A., Rossi, S., & Lisanby, S. H. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990435 · Cited by 281 · see citing works
Self-citationBOLD MRI responses to repetitive TMS over human dorsal premotor cortex
Bestmann, S., Baudewig, J., Siebner, H. R., Rothwell, J. C., & Frahm, J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.05.027 · Cited by 271 · see citing works
Rauch, S. L., Dougherty, D. D., Malone, D., Rezai, A., Friehs, G., Fischman, A. J., Alpert, N. M., Haber, S. N., Stypulkowski, P. H., Rise, M. T., et al. (2006) · Journal of Neurosurgery · doi:10.3171/jns.2006.104.4.558 · Cited by 260 · see citing works
Functional and Biochemical Alterations of the Medial Frontal Cortex in Obsessive-Compulsive Disorder
Yücel, M., Harrison, B. J., Wood, S. J., Fornito, A., Wellard, R. M., Pujol, J., Clarke, K., Phillips, M. L., Kyrios, M., Velakoulis, D., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.8.946 · Cited by 255 · see citing works
Response versus remission in obsessive-compulsive disorder
Simpson, H. B., Huppert, J. D., Petkova, E., Foa, E. B., & Liebowitz, M. R. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0214 · Cited by 241 · see citing works
Self-citationTwo phases of short-interval intracortical inhibition
Roshan, L., Paradiso, G. O., & Chen, R. E. (2003) · Experimental Brain Research · doi:10.1007/s00221-003-1502-9 · Cited by 238 · see citing works
Baer, L., Brown-Beasley, M. W., Sorce, J., & Henriques, A. L. D. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.11.1737 · Cited by 233 · see citing works
Saxena, S., Brody, A. L., Ho, M. L., Alborzian, S., Maidment, K. M., Zohrabi, N., Ho, M. K., Huang, S., Wu, H.-M., & Baxter, L. R. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.3.250 · Cited by 201 · see citing works
Thalamocortical and intracortical connections of monkey cingulate motor areas
Hatanaka, N., Tokuno, H., Hamada, I., Inase, M., Ito, Y., Imanishi, M., Hasegawa, N., Akazawa, T., Nambu, A., & Takada, M. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10720 · Cited by 146 · see citing works
Simpson, H. B., Shungu, D. C., Bender, J., Mao, X., Xu, X., Slifstein, M., & Kegeles, L. S. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.132 · Cited by 138 · see citing works
Self-citationHanajima, R., Furubayashi, T., Iwata, N. K., Shiio, Y., Okabe, S., Kanazawa, I., & Ugawa, Y. (2003) · Experimental Brain Research · doi:10.1007/s00221-003-1455-z · Cited by 133 · see citing works
Gerdelat-Mas, A., Loubinoux, I., Tombari, D., Rascol, O., Chollet, F., & Simonetta-Moreau, M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.05.009 · Cited by 131 · see citing works
Kang, D. ‐., Kwon, J. S., Kim, J., Youn, T., Park, H., Kim, M. S., Lee, D. S., & Lee, M. C. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2003.00070.x · Cited by 120 · see citing works
Riluzole suppresses motor cortex facilitation in correlation to its plasma level
Schwenkreis, P., Liepert, J., Witscher, K., Fischer, W., Weiller, C., Malin, J.-P., & Tegenthoff, M. (2000) · Experimental Brain Research · doi:10.1007/s002210000532 · Cited by 115 · see citing works
Bäumer, T., Schippling, S., Kroeger, J., Zittel, S., Koch, G., Thomalla, G., Rothwell, J. C., Siebner, H. R., Orth, M., & Münchau, A. M. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.07.035 · Cited by 108 · see citing works
Hypofunctioning of sensory gating mechanisms in patients with obsessive-compulsive disorder
Rossi, S., Bartalini, S., Ulivelli, M., Mantovani, A., Di Muro, A., Goracci, A., Castrogiovanni, P., Battistini, N., & Passero, S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.023 · Cited by 105 · see citing works
Self-citationGreenberg, B. D., Ziemann, U., Harmon, A., Murphy, D. L., & Wassermann, E. M. (1998) · The Lancet · doi:10.1016/s0140-6736(05)60009-8 · Cited by 101 · see citing works
Evidence for cortical inhibitory and excitatory dysfunction in obsessive compulsive disorder
Richter, M. A., de Jesus, D. R., Hoppenbrouwers, S., Daigle, M., Deluce, J., Ravindran, L. N., Fitzgerald, P. B., & Daskalakis, Z. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.300 · Cited by 100 · see citing works
Mantovani, A., Leckman, J. F., Grantz, H., King, R. A., Sporn, A. L., & Lisanby, S. H. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.07.011 · Cited by 98 · see citing works
Self-citationBrasil-Neto, J. P., Cammarota, Á., Valls‐Solé, J., Pascual‐Leone, Á., Hallett, M., & Cohen, L. G. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1995.tb00151.x · Cited by 86 · see citing works
Loubinoux, I., Tombari, D., Pariente, J., Gerdelat-Mas, A., Franceries, X., Cassol, E., Rascol, O., Pastor, J., & Chollet, F. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.023 · Cited by 82 · see citing works
Dysfunctions of Cortical Excitability in Drug-Naïve Posttraumatic Stress Disorder Patients
Rossi, S., Capua, A. D., Tavanti, M., Calossi, S., Polizzotto, N. R., Mantovani, A., Falzarano, V., Bossini, L., Passero, S. G., Bartalini, S., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.008 · Cited by 63 · see citing works
Self-citationCincotta, M., Giovannelli, F., Borgheresi, A., Balestrieri, F., Toscani, L., Zaccara, G., Carducci, F., Viggiano, M. P., & Rossi, S. (2010) · Brain stimulation · doi:10.1016/j.brs.2010.01.001 · Cited by 58 · see citing works
Self-citationModulation of Human Motor Cortex Excitability by Single Doses of Amantadine
Reis, J., John, D., Heimeroth, A., Mueller, H., Oertel, W., Arndt, T., & Rosenow, F. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301122 · Cited by 51 · see citing works
Leocani, L., Locatelli, M., Bellodi, L., Fornara, C., Henin, M., Magnani, G., Mennea, S., & Comı, G. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.1.140 · Cited by 45 · see citing works
Dystrophy and myogenesis inmdx diaphragm muscle
Anderson, J. E., Garrett, K. L., Moor, A. N., McIntosh, L. M., & Penner, K. M. (1998) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199809)21:9 · Cited by 45 · see citing works
Kang, S. Y., Shin, H.-W., & Sohn, Y. H. (2007) · Yonsei Medical Journal · doi:10.3349/ymj.2007.48.5.795 · Cited by 9 · see citing works
Mantovani, A., Kegeles, L., Simpson, B. H., Aly, M., Allart, A., Harrison, A. W. J., Rossi, S., & Lisanby, S. H. (2011) · Clinical Neurophysiology · doi:10.1016/s1388-2457(11)60653-6 · Cited by 1 · see citing works
Self-citation
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- Koran LM, Hanna GL, Hollander E, Nestadt G, Simpson HB, 2007 American Psychiatric Association: practice guideline for the treatment of patients with obsessive-compulsive disorder. American Journal of Psychiatry, 164;, pp. 5– 53. 17849776
- Mantovani A, Leckman J, Aly M, Harrison A, Murphy D, Lisanby S, 2012 Effect of transcranial magnetic stimulation (TMS) on clinical symptoms and motor cortex excitability measures in tourette's syndrome. International. Journal of Neuropsychopharmacology, 15;, pp. 1S– 271S.
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Self-citationTranscranial direct current stimulation in psychiatric disorders
Tortella, G. (2015) · World Journal of Psychiatry · doi:10.5498/wjp.v5.i1.88 · Cited by 154 · see citing works
Rehn, S., Eslick, G. D., & Brakoulias, V. (2018) · Psychiatric Quarterly · doi:10.1007/s11126-018-9566-7 · Cited by 142 · see citing works
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Rapinesi, C., Kotzalidis, G. D., Ferracuti, S., Sani, G., Girardi, P., & CASALE, A. D. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190409142555 · Cited by 143 · see citing works
Ahmari, S. E., & Dougherty, D. D. (2015) · Depression and Anxiety · doi:10.1002/da.22367 · Cited by 128 · see citing works
Bunse, T., Wobrock, T., Strube, W., Padberg, F., Palm, U., Falkai, P., & Hasan, A. (2013) · Brain stimulation · doi:10.1016/j.brs.2013.08.009 · Cited by 132 · see citing works
D'Urso, G., Brunoni, A. R., Mazzaferro, M. P., Anastasia, A., de Bartolomeis, A., & Mantovani, A. (2016) · Depression and Anxiety · doi:10.1002/da.22578 · Cited by 107 · see citing works
Self-citationZhou, D.-D., Wang, W., Wang, G.-M., Li, D.-Q., & Kuang, L. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.033 · Cited by 106 · see citing works
Ahmari, S. E., & Rauch, S. L. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01130-2 · Cited by 95 · see citing works
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Cleary, D. R., Ozpinar, A., Raslan, A. M. T., & Ko, A. L. (2015) · Neurosurgical FOCUS · doi:10.3171/2015.3.focus1546 · Cited by 99 · see citing works
Cuypers, K., Thijs, H., & Meesen, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086380 · Cited by 97 · see citing works
Gowda, S. M., Narayanaswamy, J. C., Hazari, N., Bose, A., Chhabra, H., Balachander, S., Bhaskarapillai, B., Shivakumar, V., Venkatasubramanian, G., & Reddy, Y. C. J. (2019) · Brain Stimulation · doi:10.1016/j.brs.2019.02.005 · Cited by 96 · see citing works
Hawken, E. R., Dilkov, D., Kaludiev, E., Simek, S., Zhang, F., & Milev, R. V. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030420 · Cited by 94 · see citing works
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Russo, M., Naro, A., Mastroeni, C., Morgante, F., Terranova, C., Muscatello, M. R., Zoccali, R., Calabrò, R. S., & Quartarone, A. (2014) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2014.02.007 · Cited by 88 · see citing works
Cocchi, L., Zalesky, A., Nott, Z., Whybird, G., Fitzgerald, P., & Breakspear, M. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.05.029 · Cited by 73 · see citing works
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Pélissolo, A., Harika‐Germaneau, G., Rachid, F., Gaudeau-Bosma, C., Tanguy, M., Benadhira, R., Bouaziz, N., Popa, T., Wassouf, I., Saba, G., et al. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw025 · Cited by 76 · see citing works
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Self-citationSeo, H., Jung, Y., Lim, H. K., Um, Y. H., Lee, C. U., & Chae, J. (2016) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2016.14.2.153 · Cited by 70 · see citing works
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D’Urso, G., Mantovani, A., Patti, S., Toscano, E., & de Bartolomeis, A. (2018) · Journal of Ect · doi:10.1097/yct.0000000000000538 · Cited by 39 · see citing works
Self-citationSaba, G., Moukheiber, A., & Pélissolo, A. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0571-3 · Cited by 39 · see citing works
Khedr, E. M., Elbeh, K., Saber, M., Abdelrady, Z., & Abdelwarith, A. M. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.025 · Cited by 36 · see citing works
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Brain functional connectivity in chronic tic disorders and Gilles de la Tourette syndrome
Naro, A., Billeri, L., Colucci, P. V., Cause, M. L., Domenico, C. D., Ciatto, L., Bramanti, P., Bramanti, A., & Calabrò, R. S. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101884 · Cited by 31 · see citing works
Giménez, M., Guinea-Izquierdo, A., Villalta‐Gil, V., Martínez‐Zalacaín, I., Segalàs, C., Subirà, M., Real, E., Pujol, J., Harrison, B. J., Haro, J. M., et al. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9601-y · Cited by 32 · see citing works
Vernieri, F., Altamura, C., Palazzo, P., Altavilla, R., Fabrizio, E., Fini, R., Melgari, J.-M., Paolucci, M., Pasqualetti, P., & Maggio, P. (2014) · Brain stimulation · doi:10.1016/j.brs.2013.12.014 · Cited by 29 · see citing works
Theta burst stimulation for the treatment of obsessive–compulsive disorder: a pilot study
Naro, A., Billeri, L., Cannavò, A., Luca, R. D., Portaro, S., Bramanti, P., & Calabrò, R. S. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02098-6 · Cited by 28 · see citing works
Homan, S., Muscat, W., Joanlanne, A., Marousis, N., Cecere, G., Hofmann, L. A., Ji, E., Neumeier, M. S., Vetter, S., Seifritz, E., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.033 · Cited by 28 · see citing works
Mantovani, A., Neri, F., D’Urso, G., Mencarelli, L., Tatti, E., Momi, D., Menardi, A., Sprugnoli, G., Santarnecchi, E., & Rossi, S. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.10.030 · Cited by 27 · see citing works
Self-citationAnimal Models for OCD Research
Chamberlain, B. L., & Ahmari, S. E. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_196 · Cited by 26 · see citing works
Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder
Zhang, K., Fan, X., Yuan, J., Yin, J., Su, H., Hashimoto, K., & Wang, G. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s209319 · Cited by 26 · see citing works
Coelho, D. R. A., Salvi, J. D., Vieira, W. F., & Cassano, P. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.25317 · Cited by 25 · see citing works
Patient-reported outcomes in obsessive-compulsive disorder
Subramaniam, M., Soh, P., Ong, C. W., Seow, E., Picco, L., Vaingankar, J. A., & Chong, S. A. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.2/msubramaniam · Cited by 22 · see citing works
Henn, M. C., Smith, H. D., Ramos, C. G. L., Shafie, B., Abaricia, J. O., Stevens, I., Rockhill, A. P., Cleary, D. R., & Raslan, A. M. (2024) · Neurosurgical FOCUS · doi:10.3171/2024.6.focus24278 · Cited by 20 · see citing works
Salatino, A., Momo, E., Nobili, M., Berti, A., & Ricci, R. (2014) · Brain stimulation · doi:10.1016/j.brs.2014.01.002 · Cited by 17 · see citing works
White matter connections within the central sulcus subserving the somato-cognitive action network
Skandalakis, G. P., Viganò, L., Neudorfer, C., Rossi, M., Fornia, L., Cerri, G., KINSMAN, K., Bajouri, Z., Tavakkoli, A. D., Koutsarnakis, C., et al. (2025) · Brain · doi:10.1093/brain/awaf022 · Cited by 20 · see citing works
Zhou, Z., Li, B., Jiang, J., Li, H., Cao, L., Zhang, S., Gao, Y., Zhang, L., Qiu, C., Huang, X., et al. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04341-z · Cited by 14 · see citing works
Schreiner, D. C., Cazares, C., Renteria, R., & Gremel, C. M. (2022) · Nature Communications · doi:10.1038/s41467-022-29807-2 · Cited by 13 · see citing works
Vidya, K. L., Rao, P. G., & Goyal, N. (2021) · Journal of Ect · doi:10.1097/yct.0000000000000791 · Cited by 11 · see citing works
Luo, G., Wang, S., Yao, S., Quan, D., Guo, G., Gao, J., & Zheng, H. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.052 · Cited by 11 · see citing works
A meta-analysis of the effects of non-invasive brain stimulation on obsessive-compulsive disorder
Gao, T., Du, J., Tian, S., & Liu, W. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114530 · Cited by 11 · see citing works
Symptom Provocation and Clinical Response to Transcranial Magnetic Stimulation
Bello, D., Jones, M., Gadiyar, I., Artim, L., Blyth, S. H., Brady, R. O., Vandekar, S., & Ward, H. B. (2025) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2025.0792 · Cited by 10 · see citing works
Balan, P. F., Gerits, A., & Vanduffel, W. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00182 · Cited by 10 · see citing works
Hoexter, M. Q., Biazoli, C. E., de Alvarenga, P. G., Batistuzzo, M. C., Salum, G. A., Gadelha, A., Pan, P. M., Anés, M., Mancini-Martins, L., Moura, L. M., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.10.009 · Cited by 9 · see citing works
Khurshid, K. A. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109529 · Cited by 9 · see citing works
Device-based physical therapies in chronic pruritus: A narrative review
Zhu, J., Zhao, X., Navarini, A. A., & Mueller, S. M. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2024.06.045 · Cited by 8 · see citing works
da Silva, D. R., Maia, A., Cotovio, G., Oliveira, J., Oliveira-Maia, A. J., & Barahona-Corrêa, B. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1050480 · Cited by 8 · see citing works
Brunoni, A. R., & Palm, U. (2019) · Springer eBooks · doi:10.1007/978-3-319-95948-1_15 · Cited by 9 · see citing works
Wang, J., Hua, G., Wang, S., Guo, G., Quan, D., Yao, S., & Zheng, H. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.01.064 · Cited by 7 · see citing works
Ruan, H., Rodriguez-Manrique, D., Winkelmann, C., Haun, J., Berberich, G., Zimmer, C., & Koch, K. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.01.055 · Cited by 6 · see citing works
Askari-Diarjani, A., & Javadi, S. A. H. S. (2022) · Middle East Current Psychiatry · doi:10.1186/s43045-022-00172-6 · Cited by 6 · see citing works
Chronic alcohol exposure alters action control via hyperactive premotor corticostriatal activity
Schreiner, D. C., Wright, A., Baltz, E. T., Wang, T., Cazares, C., & Gremel, C. M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112675 · Cited by 5 · see citing works
Successful use of transcranial magnetic stimulation in difficult to treat hypersexual disorder
Singh, A., Tripathi, A., Singh, H., & Kar, S. (2016) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.192074 · Cited by 5 · see citing works
Hashempour, S., Ansari, S., Arbabi, M., Etesam, F., Sharafi, E., vand, M. K., & Noorbala, A. A. (2022) · Clinical EEG and Neuroscience · doi:10.1177/15500594221076596 · Cited by 5 · see citing works
Chu, L., Wu, Y., Yin, J., Zhang, K., Zhong, Y., Fan, X., & Wang, G. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1350978 · Cited by 5 · see citing works
Chen, G., Zhao, X., Xie, M., Chen, H., Shao, C., Zhang, X., Wu, Y., Liu, N., & Zhang, N. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.01.013 · Cited by 5 · see citing works
Structural Brain Imaging of Obsessive-Compulsive and Related Disorders
Soriano‐Mas, C., & Harrison, B. J. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108164313.009 · Cited by 5 · see citing works
Is there potential for repetitive Transcranial Magnetic Stimulation (rTMS) as a treatment of OCD?
Zaman, R., & Robbins, T. W. (2017) · PubMed · Cited by 4 · see citing works
Outcomes with Neuromodulation in Obsessive-Compulsive Disorder
Pallanti, S., Marras, A. M., & Grassi, G. (2015) · Psychiatric Annals · doi:10.3928/00485713-20150602-07 · Cited by 4 · see citing works
Obsessive-Compulsive and Related Disorders
Barnhill, J. (2022) · Springer eBooks · doi:10.1007/978-3-319-95720-3_24 · Cited by 4 · see citing works
The Cognitive Heterogeneity of Obsessive-Compulsive Checking
Belayachi, S., & der Linden, M. V. (2017) · Journal of Cognitive Education and Psychology · doi:10.1891/1945-8959.16.1.9 · Cited by 3 · see citing works
dos Santos‐Ribeiro, S., Cabral-Passos, P. R., & de Carvalho, M. R. (2021) · Psicologia Teoria e Pesquisa · doi:10.1590/0102.3772e37212 · Cited by 3 · see citing works
Treatment effect variation in brain stimulation across psychiatric disordersPreprint
Homan, S., Muscat, W., Joanlanne, A., Marousis, N., Vetter, S., Seifritz, E., Dierks, T., & Homan, P. (2020) · medRxiv · doi:10.1101/2020.05.02.20088831 · Cited by 3 · see citing works
Khosravi, M., Khosravi, R., Tavassoli, A. R., & Najafabadi, A. J. (2026) · BMC Psychiatry · doi:10.1186/s12888-025-07723-1 · Cited by 3 · see citing works
A pilot study of fMRI targeted rTMS for obsessive compulsive disorder
Fitzgerald, P. B., Segrave, R. A., Fornito, A., Harrison, B. J., & Hoy, K. E. (2022) · Brain stimulation · doi:10.1016/j.brs.2022.02.019 · Cited by 2 · see citing works
Liu, Y., Zhao, J., Tang, Z., Hsien, Y.-K., Han, K., Shan, L., Zhang, X., & Zhang, H. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1348862 · Cited by 2 · see citing works
Chen, H., Zhang, H., Li, W., Zhang, X., Xu, Z., Wang, Z., Jiang, W., Liu, N., & Zhang, N. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.06.110 · Cited by 2 · see citing works
Maciaszek, J., Zabłocka, A., Rejek, M., Senczyszyn, A., Rudy, K., Błoch, M., Bubniak, A., Leszynska, K., Jakubczyk, D., Bogudzińska, B., et al. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.02.060 · Cited by 1 · see citing works
OCD, Anxiety Disorders, and PTSD
D’Urso, G., Sassi, T., de Bartolomeis, A., & Mantovani, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-33967-2_15 · Cited by 1 · see citing works
Self-citationTranscranial Magnetic Stimulation in Tourette Syndrome and Obsessive–Compulsive Disorder
Conelea, C. A., & McLaughlin, N. C. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812777-3.00008-8 · Cited by 1 · see citing works
Rossi, S., & Antal, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-43356-7_4 · Cited by 1 · see citing works
Self-citationKreuzer, P. M., Langguth, B., Lefaucheur, J. P., Zwanzger, P., & Notzon, S. (2015) · Nervenheilkunde · doi:10.1055/s-0038-1627655
Central Representation of Itch
Mochizuki, H., & Yosipovitch, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-33142-3_3
The Use of Transcranial Magnetic Stimulation (TMS) for Obsessive-Compulsive Disorder (OCD)
Dell’Osso, B. M., Benatti, B., & Arici, C. (2018) · Springer eBooks · doi:10.1007/978-3-319-91557-9_16
Transcranial Magnetic Stimulation in OCD
Carmi, L. (2020) · Springer eBooks · doi:10.1007/978-3-030-43356-7_8
Application of Repetitive Transcranial Magnetic Stimulation in Tourette Syndrome
Mantovani, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-43356-7_10
Self-citationMeasuring Impulsivity and Its Underlying Features in ADHD
Linhartová, P., Horký, M., Radimecká, M., Širůček, J., & Theiner, P. (2023) · Autism and child psychopathology series · doi:10.1007/978-3-031-41709-2_16
Niu, Y., & Yang, X. (2023) · Springer eBooks · doi:10.1007/978-981-99-4538-2_21
Functional connectivity in neuropsychiatric diseases
Canu, E., Tripodi, C., Gilioli, A., Filippi, M., & Agosta, F. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-19099-5.00014-3
Huang, B., Li, W., & Wang, Z. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115935
Wan, K., Liu, Y., Chen, K., He, M., Pan, W., Xiao, Y., Zhang, W., Chen, X., Yu, F., Wang, K., et al. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.116952
Chronic alcohol disrupts premotor cortex intrinsic excitability and transmission
Oesch, N. W., & Gremel, C. M. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111074
TRANSCRANIAL MAGNETIC STIMULATION (TMS) IN OBSESSIVE-COMPULSIVE DISORDER: CURRENT EVIDENCE
Guzowicz, Z., Niemiec, B., Olesiński, B., Piosik, S., Piasecki, Ł., Dudziak, N., Drozd, Z., Kamińska, M., & Gągałka, P. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.2(50).2026.5372
Neuroscience-informed psychoeducation for OCD
McLaughlin, N. C. R., Fedorenko, E. J., & Kulak, M. J. (2026) · Progress in brain research · doi:10.1016/bs.pbr.2026.10.002
- Authors
- Mantovani, A., Rossi, S., Bassi, B. D., Simpson, H. B., Fallon, B. A., & Lisanby, S. H.
- Affiliations
- University of Siena (IT)
- University of Michigan (US)
- New York State Psychiatric Institute (US)
- Duke University (US)
- Corresponding author
- Mantovani, Antonio
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 210
- Issue
- 3
- Pages
- 1026-1032
- ISSN
- 0165-1781 (ISSN-L)
- PMC
- PMC7325264
- OpenAlex
- W1981019698
- Cited by
- 98
- References
- 52
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 9 · 2015: 12 · 2014: 10 · 2013: 1
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Funders
- Department of Psychiatry, Columbia University/New York State Psychiatric Institute
- Department of Neuroscience, Siena University
- International Obsessive Compulsive Foundation
- NIH (K24 MH091555)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- obsessive-compulsive disorder, supplementary motor area, repetitive transcranial magnetic stimulation, motor cortex excitability, cortical inhibition, short-interval intracortical inhibition, intracortical facilitation, resting motor threshold, active motor threshold, hemispheric lateralization, cortical silent period, treatment outcomes, CGI-S
- MeSH terms
- Adult, Aged, Cerebral Cortex, Double-Blind Method, Female, Humans, Male, Middle Aged, Motor Cortex, Neurophysiology, Obsessive-Compulsive Disorder, Treatment Outcome, Transcranial Magnetic Stimulation
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