Taste identification used as a potential discriminative test among depression and Alzheimer׳s disease in elderly: A pilot study
Abstract
Major Depression and Alzheimer׳s disease (AD) are two diseases in the elderly characterized by an overlap of early symptoms including memory and emotional disorders. The identification of specific markers would facilitate their diagnosis. The aim of this study was to identify such markers by investigating gustatory function in depressed and AD patients. We included 20 patients with unipolar major depressive episodes (MDE), 20 patients with mild to moderate AD and 24 healthy individuals. We investigated the cognitive profile (depression, global cognitive efficiency and social/physical anhedonia) and gustatory function (ability to identify four basic tastes and to judge their intensity and hedonic value) in all participants. We found that AD patients performed worse than healthy participants in the taste identification test (for the analysis of all tastants together); however, this was not the case for depressed patients. We found no significant differences among the three groups in their ability to evaluate the intensity and hedonic value of the four tastes. Overall, our findings suggest that a taste identification test may be useful to distinguish AD and healthy controls but further investigation is required to conclude whether such a test can differentiate AD and depressed patients.
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In advanced AD, patients often complain of anhedonia.
“In advanced AD, patients often complain of anhedonia, or the inability to sense or experience pleasure (Naudin et al., 2015; Reichman and Coyne, 1995)”
From LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease (2019) · cites this paper as Naudin et al., 2015
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Heckmann, B. L., Teubner, B. J. W., Tummers, B., Boada-Romero, E., Harris, L., Yang, M., Guy, C. S., Zakharenko, S. S., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.056 · Cited by 503 · see citing works
“In advanced AD, patients often complain of anhedonia, or the inability to sense or experience pleasure (Naudin et al., 2015; Reichman and Coyne, 1995), which can be analyzed in mice using a sucrose preference test (SPT) (Briones et al., 2012; Liu et al., 2018).”
- Authors
- Naudin, M., Mondon, K., El-Hage, W., Perriot, E., Boudjarane, M., Desmidt, T., Lorette, A., Belzung, C., Hommet, C., & Atanasova, B.
- Affiliations
- Université de Tours (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Corresponding author
- Atanasova, Boriana
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 228
- Issue
- 2
- Pages
- 228-232
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2137215276
- Cited by
- 19
- References
- 33
- Citations by year
- 2024: 4 · 2023: 3 · 2022: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- taste identification, gustatory function, Alzheimer's disease, major depressive episode, depression, older adults, taste intensity, anhedonia, differential diagnosis, biomarkers
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Depression, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Memory, Middle Aged, Pilot Projects, Taste, Biomarkers, Discriminant Analysis, Case-Control Studies, Recognition, Psychology, Anhedonia
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