Unipolar depression does not moderate responses to the Sweet Taste Test
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BACKGROUND: The Sweet Taste Test (STT) measures hedonic responses to sweet tastes and has been linked to both alcoholism and to a family history of alcoholism. However, STT response profiles in unipolar major depressive disorder (MDD), a disorder characterized by anhedonia, have been minimally investigated. METHODS: Twelve adults with and 15 adults without MDD participated in two identical STT assessments separated by approximately 12 weeks. Between assessments, MDD outpatients received Behavioral Activation Therapy for Depression, a psychotherapy modality designed to increase engagement with rewarding stimuli and reduce avoidance behaviors. Primary-dependent measures included sensitivity to sucrose, hedonic response to sucrose, and designation as a Sweet-Liker or Sweet-Disliker. RESULTS: A total of 75% of adults with MDD were treatment responders. There were no significant differences in STT response profiles between groups overall or at either timepoint. Furthermore, STT profiles of MDD participants did not differ after psychotherapy, relative to baseline. CONCLUSIONS: Findings suggest that although anhedonia is a symptom of MDD, the disorder is not characterized by altered responses to sweet tastes. Implications and future directions are discussed.
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Evidence indicates preserved consummatory reward in functionally analogous tests such as the sweet taste test in major depressive disorder.
“this has been re-assessed due to evidence indicating preserved consummatory reward in functionally analogous tests (e.g., sweet taste test) in MDD [25,26].”
From Prefrontal cortex and depression (2022) · cites this paper as [25]
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Investigating dopamine and glucocorticoid systems as underlying mechanisms of anhedonia
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Depression and Approach Motivation: Differential Relations to Monetary, Social, and Food Reward
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Affective Biases in Humans and Animals
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Reconsidering depression as a risk factor for substance use disorder: Insights from rodent models
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Intact hedonic responses to sweet tastes in autism spectrum disorder
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Self-citationChronic Social Stress Leads to Reduced Gustatory Reward Salience and Effort Valuation in Mice
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Objective measures of reward sensitivity and motivation in people with high <i>v.</i> low anhedonia
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The computational structure of consummatory anhedonia
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A computational approach to understanding effort-based decision-making in depression
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Translational Assessments of Reward Responsiveness in the Marmoset
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Hedonic and disgust taste perception in borderline personality disorder and depression
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A Computational View on the Nature of Reward and Value in Anhedonia
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Rat models of reward deficits in psychiatric disorders
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Modeling the symptoms of psychopathology: A pluralistic approach
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Clinical and Preclinical Assessments of Anhedonia in Psychiatric Disorders
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A mapping review of refinements to laboratory rat housing and husbandry
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Anhedonia and Reward System: Psychobiology, Evaluation, and Clinical Features
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Social motivation in autism: Gaps and directions for measurement of a putative core construct
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- Authors
- Dichter, G. S., Smoski, M. J., Kampov-Polevoy, A. B., Gallop, R., & Garbutt, J. C.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
- West Chester University (US)
- Corresponding author
- Dichter, Gabriel S.
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2010-08-30
- Volume
- 27
- Issue
- 9
- Pages
- 859-863
- ISSN
- 1091-4269 (ISSN-L)
- PMC
- PMC2935496
- OpenAlex
- W1976598196
- Cited by
- 175
- References
- 37
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 32 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 14 · 2019: 13 · 2018: 16 · 2017: 7 · 2016: 14 · 2015: 15 · 2014: 6 · 2013: 3 · 2012: 6
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- University of North Carolina at Chapel Hill
- National Institute of Mental Health (HD40127, MH070448, NIMH K23, T32MH070448, K23MH087754, MH078145, R03MH078145, K23MH081285, MH081285)
- National Center for Research Resources (RR023248, K12RR023248)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32-HD-40127, K12HD043446, T32HD040127)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- unipolar major depression, anhedonia, sucrose sensitivity, behavioral activation therapy, treatment response, alcoholism
- MeSH terms
- Adult, Bipolar Disorder, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Psychotherapy, Sucrose, Taste, Case-Control Studies, Young Adult
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