Cited by 115Tryptophan and brain disordersSuicide and Self-Harm StudiesTreatment of Major Depression

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The role of the kynurenine pathway in suicidality in adolescent major depressive disorder

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Bradley, Kailyn A.L., Case, Julia A.C., Khan, Omar, Ricart, Thomas, Hanna, Amira, Alonso, Carmen M., Gabbay, Vilma·2015·Psychiatry Research

DOI 10.1016/j.psychres.2015.03.031PMC PMC4430385

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Abstract

The neuroimmunological kynurenine pathway (KP) has been implicated in major depressive disorder (MDD) in adults and adolescents, most recently in suicidality in adults. The KP is initiated by the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades tryptophan (TRP) into kynurenine (KYN) en route to neurotoxins. Here, we examined the KP in 20 suicidal depressed adolescents-composed of past attempters and those who expressed active suicidal intent-30 non-suicidal depressed youth, and 22 healthy controls (HC). Plasma levels of TRP, KYN, 3-hydroxyanthranilic acid (3-HAA), and KYN/TRP (index of IDO) were assessed. Suicidal adolescents showed decreased TRP and elevated KYN/TRP compared to both non-suicidal depressed adolescents and HC. Findings became more significantly pronounced when excluding medicated participants, wherein there was also a significant positive correlation between KYN/TRP and suicidality. Finally, although depressed adolescents with a history of suicide attempt differed from acutely suicidal adolescents with respect to disease severity, anhedonia, and suicidality, the groups did not differ in KP measures. Our findings suggest a possible specific role of the KP in suicidality in depressed adolescents, while illustrating the clinical phenomenon that depressed adolescents with a history of suicide attempt are similar to acutely suicidal youth and are at increased risk for completion of suicide.

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Authors: Bradley, K. A. L., Case, J. A. C., Khan, O., Ricart, T., Hanna, A., Alonso, C. M., & Gabbay, V.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
NYU Langone Health (US)
Nathan Kline Institute for Psychiatric Research (US)
Corresponding author: Gabbay, Vilma
ORCID: Case, Julia A.C.
Khan, Omar
Alonso, Carmen M.
Gabbay, Vilma
Venue: Psychiatry Research
Publisher: Elsevier BV
Published: 2015-06
Volume: 227
Issue: 2-3
Pages: 206-212
ISSN: 0165-1781 (ISSN-L)
DOI: 10.1016/j.psychres.2015.03.031
PMC: PMC4430385
OpenAlex: W2055909204
Cited by: 115
References: 48
Citations by year: 2026: 7 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 15 · 2021: 20 · 2020: 14 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 4
FWCI: 2.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (MH095807, MH101479)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: kynurenine pathway, suicidality, adolescent major depressive disorder, indoleamine 2,3-dioxygenase, tryptophan metabolism, kynurenine, 3-hydroxyanthranilic acid, suicide attempts, suicidal intent, neuroimmunology, plasma biomarkers
MeSH terms: Adolescent, Major Depressive Disorder, Female, Humans, Kynurenine, Male, Suicide, Suicide, Attempted, Tryptophan, Biomarkers, Anhedonia

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The role of the kynurenine pathway in suicidality in adolescent major depressive disorder

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