Dysfunction of neural circuitry in depressive patients with suicidal behaviors: A review of structural and functional neuroimaging studies
Abstract
Suicide is an important public problem. Understanding the neurobiological mechanisms of suicidal behavior in depression will facilitate the development of more effective prevention strategies for suicide. There are several reviews of imaging studies of suicidal behavior, but none of these reviews have focused only on suicide in depression. We reviewed neuroimaging studies of suicide in depression in recent years. The majority of studies found structural and functional alterations in the orbital frontal cortex, anterior cingulate cortex and striatum in depressive patients with suicidal behaviors. The evidence suggests that the frontal-striatal circuitry, which includes the striatum, orbital frontal and anterior cingulate cortices, is involved in the neurobiology of suicide in depressive patients. These findings also indicate that not all suicides have the same underlying neuropathology. Future studies require larger samples and more accurate subtypes of suicide. Furthermore, combining neuroimaging and other new technologies in molecular biology will be helpful to reveal the pathogenesis of suicidal behavior in depression.
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Medial prefrontal cortex showing heterogeneous FCS alterations in our study was found to have both increased and decreased FCS in previous case-control studies.
“For example, the medial prefrontal cortex showing heterogenous FCS alterations in our study was found to have both increased and decreased FCS in previous case-control studies [47, 51-53].”
From Mapping neurophysiological subtypes of major depressive disorder using normative models of the functional connectome (2023) · cites this paper as [52]
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Neural substrates of suicide and suicidal behaviour: From a neuroimaging perspective
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Reduced dorsal striatal gray matter volume predicts implicit suicidal ideation in adolescents
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- Authors
- Zhang, H., Chen, Z., Jia, Z., & Gong, Q.
- Affiliations
- West China Hospital of Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- Corresponding author
- Jia, Zhiyun
- Gong, Qiyong
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 53
- Pages
- 61-66
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2079888550
- Cited by
- 72
- References
- 81
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 3
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation (81030027, 81271532, 30900378, 81220108013)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- suicidal behavior, depression, neural circuits, orbitofrontal cortex, anterior cingulate cortex, striatum, structural neuroimaging, functional neuroimaging, suicide prevention
- MeSH terms
- Brain, Brain Mapping, Depression, Humans, Neural Pathways, Suicide, Functional Neuroimaging
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