Metabolic Profiling Identifies Phospholipids as Potential Serum Biomarkers for Schizophrenia
Abstract
Schizophrenia (SCZ) is a multifactorial psychiatric disorder. However, the molecular pathogenesis of SCZ remains largely unknown, and no reliable diagnostic test is currently available. Phospholipid metabolism is known to be disturbed during disease processes of SCZ. In this study, we used an untargeted liquid chromatography-mass spectrometry (LC-MS)-based metabolic profiling approach to measure lipid metabolites in serum samples from 119 SCZ patients and 109 healthy controls, to identify potential lipid biomarkers for the discrimination between SCZ patients and healthy controls. 51 lipid metabolites were identified to be significant for discriminating SCZ patients from healthy controls, including phosphatidylcholines (PCs), lysophosphatidylcholines (LPCs), phosphatidylethanolamines (PEs), lysophosphatidylethanolamines (LPEs) and sphingomyelins (SMs). Compared to healthy controls, most PCs and LPCs, as well as all PEs in patients were decreased, while most LPEs and all SMs were increased. A panel of six lipid metabolites could effectively discriminate SCZ patients from healthy controls with an area under the receiver-operating characteristic curve of 0.991 in the training samples and 0.980 in the test samples. These findings suggest that extensive disturbances of phospholipids may be involved in the development of SCZ. This LC-MS-based metabolic profiling approach shows potential for the identification of putative serum biomarkers for the diagnosis of SCZ.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nine studies evaluated broad panels of different lipid markers in patients with SCZ and detected statistical differences in fatty acyls, sterols, glycerolipids, sphingolipids, glycerophospholipids, and products of lipid metabolism.
“Nine studies evaluated the broad panels of different lipid markers in patients with SCZ [31,34,40,41,42,43,44,45,46] and detected statistical differences in the following lipid classes: fatty acyls, sterols, glycerolipids, sphingolipids, glycerophospholipids, and products of lipid metabolism.”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [46]
Cites
HMDB: the Human Metabolome Database
Wishart, D. S., Tzur, D., Knox, C., Eisner, R., Guo, A. C., Young, N., Cheng, D., Jewell, K., Arndt, D., Sawhney, S., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl923 · Cited by 3,219 · see citing works
A Systematic Review of the Prevalence of Schizophrenia
Saha, S., Chant, D., Welham, J., & McGrath, J. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020141 · Cited by 2,168 · see citing works
Performance of some variable selection methods when multicollinearity is present
Chong, I.-G., & Jun, C. (2005) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2004.12.011 · Cited by 2,059 · see citing works
van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971 · see citing works
A review of variable selection methods in Partial Least Squares Regression
Mehmood, T., Liland, K. H., Snipen, L. G., & Sæbø, S. (2012) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2012.07.010 · Cited by 1,597 · see citing works
Assessment of PLSDA Cross Validation
Westerhuis, J. A., Hoefsloot, H. C. J., Smit, S., Vis, D. J., Smilde, A. K., van Velzen, E. J. J., van Duijnhoven, J. P. M., & van Dorsten, F. A. (2008) · Metabolomics · doi:10.1007/s11306-007-0099-6 · Cited by 1,471 · see citing works
Dennis, E. A., Cao, J., Hsu, Y., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,213 · see citing works
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
Nguyen, L. N., Ma, D., Shui, G., Wong, P., Cazenave-Gassiot, A., Zhang, X., Wenk, M. R., Goh, E. L. K., & Silver, D. L. (2014) · Nature · doi:10.1038/nature13241 · Cited by 1,048 · see citing works
LIPID MAPS online tools for lipid research
Fahy, E., Sud, M., Cotter, D., & Subramaniam, S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm324 · Cited by 916 · see citing works
Large-Scale Human Metabolomics Studies: A Strategy for Data (Pre-) Processing and Validation
Bijlsma, S., Bobeldijk, I., Verheij, E. R., Ramaker, R., Kochhar, S., Macdonald, I. A., van Ommen, B., & Smilde, A. K. (2005) · Analytical Chemistry · doi:10.1021/ac051495j · Cited by 869 · see citing works
Metabolic Phenotyping in Health and Disease
Holmes, E. C., Wilson, I. D., & Nicholson, J. K. (2008) · Cell · doi:10.1016/j.cell.2008.08.026 · Cited by 821 · see citing works
White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction
Davis, K. L., Stewart, D. G., Friedman, J. I., Buchsbaum, M., Harvey, P. D., Hof, P. R., Buxbaum, J., & Haroutunian, V. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.443 · Cited by 793 · see citing works
Lipids of nervous tissue: Composition and metabolism
SASTRY, P. S. (1985) · Progress in Lipid Research · doi:10.1016/0163-7827(85)90011-6 · Cited by 778 · see citing works
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
Vance, J. E., & Tasseva, G. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.08.016 · Cited by 607 · see citing works
Pettegrew, J. W. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810300075011 · Cited by 482 · see citing works
Flynn, S. W., Lang, D. J., MacKay, A. L., Goghari, V. M., Vavasour, I. M., Whittall, K. P., Smith, G. N., Arango, V., Mann, J. J., Dwork, A. J., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001337 · Cited by 439 · see citing works
The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia
Na, K., Jung, H., & Kim, Y. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.022 · Cited by 425 · see citing works
Analysis of Metabolomic Data Using Support Vector Machines
Mahadevan, S., Shah, S. L., Marrie, T. J., & Slupsky, C. M. (2008) · Analytical Chemistry · doi:10.1021/ac800954c · Cited by 370 · see citing works
Neurocognitive and Social Functioning in Schizophrenia
Addington, J., & Addington, D. E. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033363 · Cited by 365 · see citing works
Metabolism and atherogenic disease association of lysophosphatidylcholine
Schmitz, G., & Ruebsaamen, K. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.05.029 · Cited by 358 · see citing works
Role Of Lipids In Brain Injury And Diseases
Rao, A. M., & Hatcher, J. F. (2007) · Future Lipidology · doi:10.2217/17460875.2.4.403 · Cited by 270 · see citing works
Metabolomic Mapping of Atypical Antipsychotic Effects in Schizophrenia
Kaddurah-Daouk, R., McEvoy, J., Baillie, R. A., Lee, D., Yao, J. K., Doraiswamy, P. M., & Krishnan, K. R. R. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002000 · Cited by 262 · see citing works
Schwarz, E., Prabakaran, S., Whitfield, P. D., Major, H. J., Leweke, F. M., Koethe, D., McKenna, P. J., & Bahn, S. (2008) · Journal of Proteome Research · doi:10.1021/pr800188y · Cited by 222 · see citing works
Lysophosphatidylcholine as a Preferred Carrier Form of Docosahexaenoic Acid to the Brain
Lagarde, M., Bernoud‐Hubac, N., BROSSARD, N., Lemaitre-Delaunay, D., Thiès, F., Croset, M., & Lecerf, J. M. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:201 · Cited by 221 · see citing works
Stanley, J. A. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950170073010 · Cited by 204 · see citing works
Identification and Validation of Urinary Metabolite Biomarkers for Major Depressive Disorder
Zheng, P., Wang, Y., Chen, L., Yang, D., Meng, H., Zhou, D., Zhong, J., Lei, Y., Melgiri, N. D., & Xie, P. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021816 · Cited by 198 · see citing works
Liu, X., Zheng, P., Zhao, X., Zhang, Y., Hu, C., Li, J., Zhao, J., Zhou, J., Xie, P., & Xu, G. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00144 · Cited by 193 · see citing works
Schizophrenia shows a unique metabolomics signature in plasma
He, Y., Yu, Z., Giegling, I., Xie, L., Hartmann, A. M., Prehn, C. P., Adamski, J., Kahn, R. S., Li, Y., Illig, T., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.76 · Cited by 170 · see citing works
Orešič, M., Seppänen‐Laakso, T., Sun, D., Tang, J. P., Therman, S., Viehman, R., Mustonen, U., van Erp, T. G., Hyötyläinen, T., Thompson, P. M., et al. (2012) · eScholarship (California Digital Library) · Cited by 168 · see citing works
Xuan, J., Pan, G., Qiu, Y., Yang, L., Su, M., Liu, Y., Chen, J., Feng, G., Fang, Y., Jia, W. P., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr2006796 · Cited by 160 · see citing works
Metabolome in schizophrenia and other psychotic disorders: a general population-based study
Orešič, M., Tang, J. P., Seppänen‐Laakso, T., Mattila, I. M., Saarni, S. E., Saarni, S. I., Lönnqvist, J. K., Sysi‐Aho, M., Hyötyläinen, T., Perälä, J., et al. (2011) · Genome Medicine · doi:10.1186/gm233 · Cited by 158 · see citing works
Misiak, B., Stańczykiewicz, B., Łaczmański, Ł., & Frydecka, D. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.031 · Cited by 151 · see citing works
Lipidomics in translational research and the clinical significance of lipid-based biomarkers
Stephenson, D., Hoeferlin, L. A., & Chalfant, C. E. (2017) · Translational research · doi:10.1016/j.trsl.2017.06.006 · Cited by 136 · see citing works
Altered thalamic membrane phospholipids in schizophrenia: a postmortem study
Schmitt, A., Wilczek, K., Blennow, K., Maras, A., Jatzko, A., Petroianu, G. A., Braus, D. F., & Gattaz, W. F. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.019 · Cited by 134 · see citing works
Okada, T., Afendi, F. M., Altaf‐Ul‐Amin, M., Takahashi, H., Nakamura, K., & Kanaya, S. (2010) · Current Computer - Aided Drug Design · doi:10.2174/157340910791760055 · Cited by 134 · see citing works
Chadeau‐Hyam, M., Ebbels, T. M. D., Brown, I., Chan, Q. M., Stamler, J., Huang, C. C., Daviglus, M. L., Ueshima, H., Zhao, L., Holmes, E. C., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr1003449 · Cited by 128 · see citing works
Sundaram, J. R., Chan, E. S., Poore, C. P., Pareek, T. K., Cheong, W. F., Shui, G., Tang, N., Low, C., Wenk, M. R., & Kesavapany, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5177-11.2012 · Cited by 127 · see citing works
McEvoy, J., Baillie, R. A., Zhu, H., Buckley, P., Keshavan, M. S., Nasrallah, H. A., Dougherty, G. G., Yao, J. K., & Kaddurah-Daouk, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068717 · Cited by 127 · see citing works
Omics-Based Biomarkers: Application of Metabolomics in Neuropsychiatric Disorders
Sethi, S., & Brietzke, E. M. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv096 · Cited by 122 · see citing works
Gonzalez-Liencres, C., Taş, C., Brown, E. C., Erdin, S., Onur, E., Çubukcoǧlu, Z., Aydemır, Ö., Esen-Danacı, A., & Brüne, M. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0268-x · Cited by 118 · see citing works
Origin of plasma lysophosphatidylcholine: evidence for direct hepatic secretion in the rat.
Sekas, G., Patton, G. M., Ec, L., & Robins, S. J. (1985) · PubMed · Cited by 113 · see citing works
Tessier, C., Sweers, K., Frajerman, A., Bergaoui, H., Ferreri, F., Delva, C., Lapidus, N., Lamazière, A., Roiser, J. P., Hert, M. A. F. D., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.142 · Cited by 101 · see citing works
Erythrocyte membrane phospholipids in psychotic patients
Keshavan, M. S., Mallinger, A. G., Pettegrew, J. W., & Dippold, C. S. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90032-c · Cited by 95 · see citing works
Changes in Levels of Phosphorus Metabolites in Temporal Lobes of Drug-Naive Schizophrenic Patients
Fukuzako, H., Fukuzako, T., Hashiguchi, T., Kodama, S., Takigawa, M., & Fujimoto, T. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1205 · Cited by 92 · see citing works
Hamazaki, K., Choi, K. H., & Kim, H. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.11.017 · Cited by 80 · see citing works
Preprocessing and Pretreatment of Metabolomics Data for Statistical Analysis
Karaman, İ. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-47656-8_6 · Cited by 79 · see citing works
Chen, Y., Shen, G., Zhang, R., He, J., Zhang, Y., Xu, J., Yang, W. Q., Chen, X., Song, Y., & Abliz, Z. (2013) · Analytical Chemistry · doi:10.1021/ac401400b · Cited by 69 · see citing works
Castillo-Passi, R. I., Rojo, L. E., Henríquez‐Henríquez, M., Hernán Silva, I., Maturana, A., Villar, M. J., Fuentes, M., & Gaspar, P. A. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00488 · Cited by 52 · see citing works
Hasegawa, H., Jin, L., Matsumoto, T., Onishi, S., Suemori, K., & Yasukawa, M. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.119 · Cited by 51 · see citing works
Dysfunctional plasmalogen dynamics in the plasma and platelets of patients with schizophrenia
Wood, P. L., Unfried, G., Whitehead, W. F., Phillipps, A., & Wood, J. A. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.11.032 · Cited by 50 · see citing works
Analytical approaches for lipidomics and its potential applications in neuropsychiatric disorders
Sethi, S., Hayashi, M. A. F., Sussulini, A., Tasić, L., & Brietzke, E. M. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1117656 · Cited by 44 · see citing works
Metabolic Profiling: Are We En Route to Better Diagnostic Tests for Cancer?
Gu, H., Gowda, G. N., & Raftery, D. (2012) · Future Oncology · doi:10.2217/fon.12.113 · Cited by 43 · see citing works
Weber‐Fahr, W., Englisch, S., Esser, A., Tunc‐Skarka, N., Meyer‐Lindenberg, A., Ende, G., & Zink, M. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.06.011 · Cited by 42 · see citing works
Phospholipid patterns of erythrocytes in schizophrenia: relationships to symptomatology
Ponizovsky, A. M., Modai, I., Nechamkin, Y., Barshtein, G., Ritsner, M., Yedgar, S., Lecht, S., & Bergelson, L. D. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00189-4 · Cited by 42 · see citing works
Subbaiah, P. V., Jiang, X.-C., Belikova, N. A., Aizezi, B., Huang, Z., & Reardon, C. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.02.007 · Cited by 35 · see citing works
Lipidomics, Biomarkers, and Schizophrenia: A Current Perspective
Sethi, S., Hayashi, M. A. F., Correia, B. S. B., Pontes, J. G. D. M., Tasić, L., & Brietzke, E. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-47656-8_11 · Cited by 29 · see citing works
Reichel, M., Hönig, S., Liebisch, G., Lüth, A., Kleuser, B., Gulbins, E., Schmitz, G., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.08.005 · Cited by 28 · see citing works
Dysfunctional glycosynapses in schizophrenia: Disease and regional specificity
Wood, P. L., & Holderman, N. R. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.05.017 · Cited by 28 · see citing works
Huang, J., Park, H., Iaconelli, J., Berkovitch, S. S., Watmuff, B., McPhie, D. L., Öngür, D., Cohen, B. M., Clish, C. B., & Karmacharya, R. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00628 · Cited by 28 · see citing works
Abnormal transbilayer distribution of phospholipids in red blood cell membranes in schizophrenia
Nuss, P., Tessier, C., Ferreri, F., Binder, M. D., Peuskens, J., Trugnan, G., Masliah, J., & Wolf, C. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2009.01.009 · Cited by 26 · see citing works
Accumulation of N-Acylphosphatidylserines and N-Acylserines in the Frontal Cortex in Schizophrenia
Wood, P. L. (2015) · Neurotransmitter · doi:10.14800/nt.263 · Cited by 20 · see citing works
Takatera, A., Takeuchi, A., Saiki, K., Morioka, I., Yokoyama, N., & Matsuo, M. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e31814625ca · Cited by 19 · see citing works
Changes in the Lipid Phase of Erythrocyte Membranes in Patients with Paranoid Schizophrenia
Ryazantsevа, N. V., Новицкий, В. В., & Kublinskaya, M. M. (2002) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1015172914991 · Cited by 12 · see citing works
Qi, Y., Song, Y., Gu, H., Fan, G., & Chai, Y. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1258-2_2 · Cited by 10 · see citing works
Orešič, M., Seppänen-Laakso, T., Sun, D., Tang, J., Therman, S., Viehman, R., Mustonen, U., van Erp, T. G., Hyötyläinen, T., Thompson, P., et al. (2012) · Genome Medicine · doi:10.1186/gm300 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Brain lipidomics: From functional landscape to clinical significance
Yoon, J. H., Seo, Y., Jo, Y. S., Lee, S., Cho, E., Cazenave-Gassiot, A., Shin, Y.-S., Moon, M. H., An, H. J., Wenk, M. R., et al. (2022) · Science Advances · doi:10.1126/sciadv.adc9317 · Cited by 324 · see citing works
Knuplez, E., & Marsche, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124501 · Cited by 236 · see citing works
Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations
Panyard, D. J., Kim, K. M., Darst, B. F., Deming, Y. K., Zhong, X., Wu, Y., Kang, H., Carlsson, C. M., Johnson, S. C., Asthana, S., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01583-z · Cited by 179 · see citing works
Dietary phospholipids: Role in cognitive processes across the lifespan
Schverer, M., O’Mahony, S. M., O’Riordan, K. J., Donoso, F., Roy, B. L., Stanton, C., Dinan, T. G., Schellekens, H., & Cryan, J. F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.012 · Cited by 91 · see citing works
Design of Multi‐Shelled Hollow Cr 2 O 3 Spheres for Metabolic Fingerprinting
Li, R., Zhou, Y., Liu, C., Pei, C., Shu, W., Zhang, C., Liu, L., Zhou, L., & Wan, J. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202101007 · Cited by 80 · see citing works
Tkachev, A., Stekolshchikova, E., Vanyushkina, A., Zhang, H., Morozova, A. Y., Zozulya, S. A., Kurochkin, I., Anikanov, N. A., Egorova, A., Yushina, E., et al. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.4350 · Cited by 78 · see citing works
Impaired membrane lipid homeostasis in schizophrenia
Li, M., Gao, Y., Wang, D., Hu, X., Jiang, J., Qing, Y., Yang, X., Cui, G., Wang, P., Zhang, J., et al. (2022) · Schizophrenia Bulletin · doi:10.1093/schbul/sbac011 · Cited by 63 · see citing works
Multi-Omics Analysis Reveals Aberrant Gut-Metabolome-Immune Network in Schizophrenia
Fan, Y., Gao, Y., Ma, Q., Yang, Z., Zhao, B., He, X., Yang, J., Yan, B., Gao, F., Li, Q., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.812293 · Cited by 56 · see citing works
Theriault, J. E., Shaffer, C., Dienel, G. A., Sander, C. Y. M., Hooker, J. M., Dickerson, B. C., Barrett, L. F., & Quigley, K. S. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105373 · Cited by 55 · see citing works
Mocking, R. J. T., Naviaux, J. C., Li, K., Wang, L., Monk, J. M., Bright, A. T., Figueroa, C. A., Schene, A. H., Ruhé, H. G., Assies, J., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01182-w · Cited by 40 · see citing works
Metabolic features of treatment-refractory major depressive disorder with suicidal ideation
Pan, L. A., Naviaux, J. C., Wang, L., Li, K., Monk, J. M., Lingampelly, S. S., Segreti, A. M., Bloom, K., Vockley, J. E., Tarnopolsky, M. A., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02696-9 · Cited by 40 · see citing works
Coccidioidomycosis Detection Using Targeted Plasma and Urine Metabolic Profiling
Jasbi, P., Mitchell, N. M., Shi, X., Grys, T. E., Wei, Y., Liu, L., Lake, D. F., & Gu, H. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00100 · Cited by 37 · see citing works
Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers
Zorkina, Y., Ushakova, V., Ochneva, A., Tsurina, A., Abramova, O., Savenkova, V., Goncharova, A., Alekseenko, I., Morozova, I., Riabinina, D., et al. (2024) · Metabolites · doi:10.3390/metabo14020080 · Cited by 36 · see citing works
Song, M., Liu, Y., Zhou, J., Shi, H., Su, X., Shao, M., Yang, Y., Wang, X., Zhao, J., Guo, D., et al. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115070 · Cited by 32 · see citing works
Ding, Y., Pei, C., Shu, W., & Wan, J. (2021) · Chemistry - An Asian Journal · doi:10.1002/asia.202101310 · Cited by 31 · see citing works
Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia
Juchnowicz, D., Dzikowski, M., Róg, J., Waszkiewicz, N., Zalewska, A., Maciejczyk, M., & Karakuła‐Juchnowicz, H. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.728986 · Cited by 29 · see citing works
Wang, D., Sun, X., Maziade, M., Mao, W., Zhang, C., Wang, J., & Cao, B. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2020.1769188 · Cited by 26 · see citing works
Seabra, G., de Almeida, V., Reis‐de‐Oliveira, G., Crunfli, F., Antunes, A. S. L. M., & Martins‐de‐Souza, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-69543-5 · Cited by 24 · see citing works
Zhou, Y., Zou, X., Feng, R., Zhan, X., Hong, H., Luo, Y., & Tan, Y. (2023) · Nutrients · doi:10.3390/nu15030534 · Cited by 21 · see citing works
Validated metabolomic biomarkers in psychiatric disorders: a narrative review
Konjevod, M., Sáiz, J., Bordoy, L., Štrac, D. Š., Taha, A. Y., Lanceros-Méndez, S., & Alonso, R. M. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01258-7 · Cited by 20 · see citing works
A Metabolomics Study of Serum in Hospitalized Patients With Chronic Schizophrenia
Okamoto, N., Ikenouchi, A., Watanabe, K., Igata, R., Fujii, R., & Yoshimura, R. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.763547 · Cited by 20 · see citing works
Wang, F., Guo, L., Zhang, T., Cui, Z., Wang, J., Zhang, C., Xue, F., Zhou, C., Li, B., Tan, Q., et al. (2022) · Medicina · doi:10.3390/medicina58111509 · Cited by 18 · see citing works
Horská, K., Kotolová, H., Karpíšek, M., Babinská, Z., Hammer, T., Procházka, J. H., Štark, T., Micale, V., & Kučerová, J. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115214 · Cited by 17 · see citing works
Couttas, T. A., Jieu, B., Rohleder, C., & Leweke, F. M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.885904 · Cited by 17 · see citing works
Dysregulation of Serum Exosomal Lipid Metabolism in Schizophrenia: A Biomarker Perspective
Xu, C.-X., Huang, W., Shi, X., Du, Y., Liang, J., Fang, X., Chen, H.-Y., & Cheng, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04477-x · Cited by 16 · see citing works
Lipidomic profiling of amniotic fluid and its application in fetal lung maturity prediction
Cao, Z., Liu, J., Xie, X., Zhan, S., Song, W., Wu, S., Sun, Z., Dong, Y., Tang, G., Liu, Y., et al. (2019) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23109 · Cited by 16 · see citing works
Screening for depression in the general population through lipid biomarkers
Tkachev, A., Stekolshchikova, E., Golubova, A., Serkina, A., Morozova, A. Y., Zorkina, Y., Riabinina, D., Golubeva, E., Ochneva, A., Savenkova, V., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105455 · Cited by 15 · see citing works
Dey, M., Gunn‐Moore, F. J., Platt, B., & Smith, T. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01367-8 · Cited by 15 · see citing works
Discovery of biological markers for schizophrenia based on metabolomics: a systematic review
Yao, G., Zeng, J., Huang, Y. C., Lu, H., Ping, J., Wan, J., Jiang, T., Deng, F., Li, C., Liu, X., et al. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1540260 · Cited by 14 · see citing works
Łuczaj, W., Jastrząb, A., Domingues, M. R., Domingues, P. M., & Skrzydlewska, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168700 · Cited by 13 · see citing works
Identification of Plasma Biomarkers in Drug-Naïve Schizophrenia Using Targeted Metabolomics
Su, Q., Bi, F., Yang, S., Yan, H., Sun, X., Wang, J., Qiu, Y., Li, M., Li, S., & Li, J. (2023) · Psychiatry Investigation · doi:10.30773/pi.2023.0121 · Cited by 12 · see citing works
Li, M., Yang, X., Sun, L., Qing, Y., Hu, X., Jiang, J., Wang, D., Cui, G., Gao, Y., Zhang, E., et al. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.02.016 · Cited by 12 · see citing works
Hylén, U., McGlinchey, A. J., Orešič, M., Bejerot, S., Humble, M. B., Särndahl, E., Hyötyläinen, T., & Eklund, D. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.778325 · Cited by 13 · see citing works
Shorter Chain Triglycerides Are Negatively Associated with Symptom Improvement in Schizophrenia
Tkachev, A., Stekolshchikova, E., Anikanov, N., Zozulya, S., Barkhatova, A., Klyushnik, T., & Petrova, D. (2021) · Biomolecules · doi:10.3390/biom11050720 · Cited by 11 · see citing works
Joaquim, H. P. G., Costa, A. C., Talib, L. L., Dethloff, F., Serpa, M. H., Zanetti, M. V., van de Bilt, M. T., & Turck, C. W. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00496 · Cited by 9 · see citing works
Ceramides: Shared Lipid Biomarkers of Cardiovascular Disease and Schizophrenia
Tkachev, A., Stekolshchikova, E., Morozova, A. Y., Anikanov, N. A., Zorkina, Y., Alekseyeva, P. N., Khobta, E. B., Andreyuk, D., Zozulya, S. A., Barkhatova, A., et al. (2021) · Consortium Psychiatricum · doi:10.17816/cp101 · Cited by 8 · see citing works
Theriault (n.d.) · doi:10.31234/osf.io/pkzr8 · Cited by 51 · see citing works
Yin, X., Mongan, D., Cannon, M. D., Zammit, S., Hyötyläinen, T., Orešič, M., Brennan, L., & Cotter, D. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.02.029 · Cited by 7 · see citing works
Yan, H., Li, G., Zhang, X., Zhang, C., Li, M., Qiu, Y., Sun, W., Dong, Y., Li, S., & Li, J. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05805-0 · Cited by 6 · see citing works
Design of Multi‐Shelled Hollow Cr2O3Spheres for Metabolic Fingerprinting
Li, R., Zhou, Y., Liu, C., Pei, C., Shu, W., Zhang, C., Liu, L., Zhou, L., & Wan, J. (2021) · Angewandte Chemie · doi:10.1002/ange.202101007 · Cited by 6 · see citing works
Network reconstruction for trans acting genetic loci using multi-omics data and prior information
Hawe, J. S., Saha, A., Waldenberger, M., Kunze, S., Wahl, S., Müller‐Nurasyid, M., Prokisch, H., Grallert, H., Herder, C., Peters, A., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01124-9 · Cited by 5 · see citing works
Sun, J., Lu, Z., Kang, Z., Zhang, Y., Sun, Y., Zhao, G., Bo, Q., Li, W., Yi, Z., Chen, B., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02431-4 · Cited by 5 · see citing works
Identifying serum lipidomic signatures related to prognosis in first-episode schizophrenia
Luo, M., Zhang, S., Xue, J., Gao, T., Li, X., Zhai, Z., Lu, C., Dong, Y., Zhuo, K., Xiang, Q., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06802-7 · Cited by 5 · see citing works
Jieu, B., Sykorova, E. B., Rohleder, C., Marcolini, E., Hoffmann, A., Koethe, D., Leweke, F. M., & Couttas, T. A. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116005 · Cited by 6 · see citing works
Plasma and Serum LC-MS Lipidomic Fingerprints of Bipolar Disorder and Schizophrenia
Takić, M. M., Jovanović, V. B., Marković, S., Miladinović, Z. P., Jadranin, M. B., Krstić, G., Miljević, Č., Tešević, V., & Mandić, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136134 · Cited by 4 · see citing works
LC–HRMS Lipidomic Fingerprints in Serbian Cohort of Schizophrenia Patients
Marković, S., Jadranin, M. B., Miladinović, Z. P., Gavrilović, A., Avramović, N., Takić, M. M., Tasić, L., Tešević, V., & Mandić, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910266 · Cited by 4 · see citing works
Zhao, S., Chen, J., Zhong, C., Meng, L., & Wang, Y. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116044 · Cited by 4 · see citing works
Blood Plasma Lipid Alterations Differentiating Psychotic and Affective Disorder Patients
Golubova, A., Stekolshchikova, E., Гареева, А. Э., Akhmerova, I. Y., Тимербулатов, И. Ф., Zakurazhnaya, V., Riabinina, D., Reznik, A. M., Morozova, A. Y., Andreyuk, D., et al. (2025) · Biomolecules · doi:10.3390/biom15091296 · Cited by 3 · see citing works
Dai, S., Long, Y., Xiao, J., Wang, Y., Wang, X., Shao, P., Huang, M., Xu, Y., Liu, F., Tang, Y., et al. (2025) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2025.104387 · Cited by 3 · see citing works
Nazar, N., & Chatterjee, N. S. (2025) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2025.100615 · Cited by 2 · see citing works
Wang, Z., Wang, Y., Jiang, H., Chen, L., & Zhang, X. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s537721 · Cited by 2 · see citing works
Liu, Y., Lin, H., Liu, M., Lin, L., & Wen, Y. (2024) · Psychiatry Investigation · doi:10.30773/pi.2024.0011 · Cited by 2 · see citing works
TET1 displays catalytic and non-catalytic functions in the adult mouse cortex
Foong, Y. H., Caldwell, B. A., Thorvaldsen, J. L., Krapp, C. J., Mesaros, C., Zhou, W., Kohli, R. M., & Bartolomei, M. S. (2024) · Epigenetics · doi:10.1080/15592294.2024.2374979 · Cited by 2 · see citing works
Ling, W., Wang, W., Lü, D., Liu, Q. S., & Jiang, G. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00708 · Cited by 1 · see citing works
Chen, H., Zhang, Q., Ai, Z., Zhang, L., & Li, X. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1575431 · Cited by 1 · see citing works
Okamoto, L., Watanabe, S., Deno, S., Nie, X., Maruyama, J., Tomita, M., Hatano, A., & Yugi, K. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.12.006 · Cited by 1 · see citing works
Metabolomics: From Scientific Research to the Clinical Diagnosis
Estrella-Parra, E. A., Espinosa‐González, A. M., García‐Bores, A. M., Nolasco-Ontiveros, E., Rivera-Cabrera, J. C., Hernández, T., Castro, I. P., & Ávila-Acevedo, J. G. (2022) · Springer eBooks · doi:10.1007/978-3-030-89601-0_7
Multiomics Approaches in Psychiatric Disorders
Schulte, E. C., Kohshour, M. O., Tkachev, A., Khaitovich, P., & Schulze, T. G. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_30-1
Biomarkers Related to the Hypotheses of the Pathophysiology of Schizophrenia Spectrum Disorders
Gallo, M. B. C. (2024) · Springer eBooks · doi:10.1007/978-3-031-59028-3_3
Multiomics Approaches in Psychiatric Disorders
Schulte, E. C., Kohshour, M. O., Tkachev, A., Khaitovich, P., & Schulze, T. G. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_30
Trans-omics: Lipidomics, Transcriptomics, and Proteomics. Applications to Schizophrenia
Rahman, M. M., Chi, Z., Sano, F., Kahyo, T., Yamasue, H., & Setou, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_135-1
A polyunsaturated fatty acid (PUFA) theory of schizophrenia
Rappoport, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-44-345008-2.00009-6
Trans-omics: Lipidomics, Transcriptomics, and Proteomics—Applications to Schizophrenia
Rahman, M. M., Chi, Z., Sano, F., Kahyo, T., Yamasue, H., & Setou, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_135
Agrawal, U., Nataraj, P., Chandramouli, A., Krishnan, S., Kamat, S. S., Urulangodi, M., & Thakur, P. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.02.679990
Ren, Y., Zheng, T., Liu, R., Zhao, Y., Zhang, Z., Si, T., & Zhang, R. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120858
Yan, H., Li, G., Zhang, X., Zhang, C., Li, M., Qiu, Y., Sun, W., Dong, Y., Li, S., & Li, J. (2024) · Figshare · doi:10.6084/m9.figshare.26719629
Hawe, J. S., Saha, A., Waldenberger, M., Kunze, S., Wahl, S., Müller‐Nurasyid, M., Prokisch, H., Grallert, H., Herder, C., Peters, A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21520292
Weber, A., Papiol, S., Tkachev, A., Senner, F., Reich‐Erkelenz, D., Navarro‐Flores, A., Kohshour, M. O., Heilbronner, U., Heilbronner, M., Budde, M., et al. (2026) · medRxiv · doi:10.64898/2026.01.06.26343451
Li, F., Yang, Y., Fu, Y., Zhang, S., Wu, P., Wang, J., Dong, Y., Wu, N., He, X., Wang, T., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03472-z
Plasma Lipid Alterations Track Multidimensional Psychosis Severity Across Diagnostic BoundariesPreprint
Thanabalasingam, A., Wiegand, A., Meijer, J., Dwyer, D., Schulte, E. C., & Study, T. P. (2026) · medRxiv · doi:10.64898/2026.02.24.26346956
Abomoelak, B., Kapoor, N., Schreck, M., Pragya, S. U., Pragya, S. U., Mehta, N. D., Bozelli, J. C., Shanmuganathan, M., Kroezen, Z., Britz‐McKibbin, P., et al. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1741802
Lin, K., Wang, P., Li, S., Ma, C., Wen, D., Wang, X., & Liao, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1712425
Species-selective plasma metabolism drives lysophosphatidylcholine depletion after cardiac arrest
Shoaib, M., Kazmi, J. S., Nishikimi, M., Choudhary, R. C., Cho, J., Yin, T., Singh, P., Kuschner, C. E., Choi, J., Espin, B. B., et al. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113536
- Authors
- Wang, D., Cheng, S. L., Fei, Q., Gu, H., Raftery, D., Cao, B., Sun, X., Yan, J., Zhang, C., & Wang, J.
- Affiliations
- Peking University (CN)
- University of Washington (US)
- Jilin University (CN)
- Arizona State University (US)
- Corresponding author
- Wang, Jingyu
- ORCID
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 272
- Pages
- 18-29
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2905146838
- Cited by
- 73
- References
- 64
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 14 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 8 · 2019: 2
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Peking University Health Science Center Medical Cross Disciplinary Fund (BMU20140435)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- schizophrenia, serum biomarkers, phospholipids, lipid metabolism, phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, lysophosphatidylethanolamine, sphingomyelin, diagnostic biomarker panel, untargeted metabolomics
- MeSH terms
- Adult, Chromatography, Liquid, Female, Humans, Male, Middle Aged, Phospholipids, Schizophrenia, Biomarkers, Tandem Mass Spectrometry, Metabolomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
