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Cited by 25Schizophrenia research and treatmentAntioxidant Activity and Oxidative StressTryptophan and brain disorders

Effects of antipsychotics on antioxidant defence system in patients with schizophrenia: A meta-analysis

Goh, Xue Xin, Tang, Pek Yee, Tee, Shiau Foon·2022·Psychiatry Research
DOI 10.1016/j.psychres.2022.114429
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Abstract

Theory of oxidative stress is suggested in the pathophysiology of schizophrenia. To determine the cause of impaired antioxidant defense system in schizophrenia, a meta-analysis was performed by selecting studies published from 1964 to 2021 from Pubmed and Scopus databases. Data were analysed using Comprehensive Meta-Analysis version 2 and calculated effect sizes were compared between unmedicated and medicated patients with schizophrenia and healthy controls. Heterogeneity, publication bias assessments and subgroup analyses of drug-free and drug-naïve patients, and patients treated with atypical and typical antipsychotics were conducted. Subgroup analysis of confounding factors including age, gender, illness duration and patient status was also conducted. We found that glutathione peroxidase (GPx) was significantly decreased in all patients. Significantly lower catalase (CAT), glutathione (GSH) and albumin (ALB) were found in unmedicated patients only. Both groups showed significantly weakened non-enzymatic antioxidant capacity. Subgroup analyses indicated that weakened non-enzymatic antioxidant capacity may be associated with schizophrenia. Antioxidant status was more impaired in drug-free patients compared with other subgroups. This indicated that antipsychotics may improve antioxidant defense system. Although effect sizes were smaller, future studies may focus on the effect of antipsychotic discontinuation. In overall, schizophrenia was associated with impaired antioxidant defense system especially the non-enzymatic antioxidant system.

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  • In three groups of treated and untreated patients with schizophrenia and healthy controls, GPx was significantly lowered in both groups of patients; untreated patients revealed decreased levels of CAT, GSH, and albumin; both groups showed significantly lowered non-enzymatic antioxidant capacity; antioxidant status was most significantly impaired in untreated patients, confirming level of抗氧化剂 in患者与

    “It was found that the enzyme glutathione peroxidase (GPx) was significantly lowered in both groups of patients. Untreated patients revealed decreased levels of catalase (CAT), glutathione (GSH), and albumin. Both groups of patients, treated and untreated showed significantly lowered non-enzymatic antioxidant capacity. Antioxidant status was most significantly impaired in untreated patients, confir”

    From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Goh et al. 2022

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Authors
Goh, X. X., Tang, P. Y., & Tee, S. F.
Affiliations
Universiti Tunku Abdul Rahman Sungai Long Campus (MY)
Corresponding author
Tee, Shiau Foon
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2022-03
Volume
309
Pages
114429
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2022.114429
OpenAlex
W4213100652
Cited by
25
References
83
Citations by year
2026: 5 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 4
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
schizophrenia, antipsychotic drugs, antioxidant defense, oxidative stress, glutathione peroxidase, catalase, glutathione, albumin, atypical antipsychotics, typical antipsychotics, unmedicated patients, drug-naive patients
MeSH terms
Antioxidants, Glutathione, Glutathione Peroxidase, Humans, Schizophrenia, Antipsychotic Agents, Oxidative Stress

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