Meta-analysis of oxidative stress in schizophrenia.

Flatow, Joshua; Buckley, Peter; Miller, Brian J.

doi:10.1016/j.biopsych.2013.03.018

Cited by 491Schizophrenia research and treatmentAntioxidant Activity and Oxidative StressTryptophan and brain disorders

Meta-analysis of oxidative stress in schizophrenia.

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Flatow, Joshua, Buckley, Peter, Miller, Brian J.·2013·Biological Psychiatry

DOI 10.1016/j.biopsych.2013.03.018PMC PMC4018767

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Abstract

Background Schizophrenia is associated with impaired antioxidant defense, including abnormal serum, plasma, and red blood cell (RBC) oxidative stress parameters. We performed a meta-analysis of these associations, considering the effect of clinical status and antipsychotic treatment after an acute exacerbation of psychosis.Methods We identified articles by searching PubMed, PsychInfo, and Institute for Scientific Information, and the reference lists of identified studies.Results Forty-four studies met the inclusion criteria. Total antioxidant status seemed to be a state marker, because levels were significantly decreased in cross-sectional studies of serum and plasma in first-episode psychosis (FEP) and significantly increased in longitudinal studies of antipsychotic treatment for acute exacerbations of psychosis (p < .01 for each). The RBC catalase and plasma nitrite seemed to be state-related markers, because levels in cross-sectional studies were significantly decreased in FEP (p < .01) and significantly increased in stable outpatients (p = .01). In contrast, RBC superoxide dismutase seemed to be a trait marker for schizophrenia, because levels in cross-sectional studies were significantly decreased in acutely relapsed inpatients, FEP, and stable outpatients (p < .01 for each).Conclusions Oxidative stress abnormalities in FEP suggest an effect that might be independent of antipsychotic medications. Although some parameters (total antioxidant status, RBC catalase, and plasma nitrite) might be state markers for acute exacerbations of psychosis, others (RBC superoxide dismutase) might be trait markers; however, more longitudinal studies are needed. Our findings suggest that oxidative stress might serve as a potential biomarker in the etiopathophysiology and clinical course of schizophrenia.

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Redox dysregulation has been observed in schizophrenic patients, who have defective antioxidant systems and exhibit increased lipid peroxidation.
“Redox dysregulation has been observed in schizophrenic patients, who have defective antioxidant systems and exhibit increased lipid peroxidation (Do et al., 2000; Yao et al., 2006; Flatow et al., 2013).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Flatow et al., 2013

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Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment
Khandaker, G. M., Cousins, L., Deakin, J., Lennox, B. R., Yolken, R., & Jones, P. B. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00122-9 · Cited by 926 · see citing works
A Meta-analysis of oxidative stress markers in depression
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Authors: Flatow, J., Buckley, P., & Miller, B. J.
Affiliations: Augusta University (US)
ORCID: Buckley, Peter
Miller, Brian J.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2013-09
Volume: 74
Issue: 6
Pages: 400-409
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2013.03.018
PMC: PMC4018767
OpenAlex: W2060038783
Cited by: 491
References: 163
Citations by year: 2026: 33 · 2025: 37 · 2024: 21 · 2023: 31 · 2022: 46 · 2021: 48 · 2020: 40 · 2019: 41 · 2018: 48 · 2017: 44 · 2016: 39 · 2015: 35 · 2014: 24 · 2013: 4
FWCI: 4.63
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (K23MH098014)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: schizophrenia, oxidative stress, antioxidant defense, first-episode psychosis, antipsychotic drugs, total antioxidant status, catalase, superoxide dismutase, nitrite, biomarkers
MeSH terms: Humans, Schizophrenia, Oxidative Stress

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