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Cited by 79Adrenal Hormones and DisordersStress Responses and CortisolThyroid Disorders and Treatments

The risk of affective disorders in patients with adrenocortical insufficiency

Thomsen, Anders F., Kvist, Tine K., Andersen, Per K., Kessing, Lars V.·2006·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2006.01.003
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Abstract

Objective To investigate the risk of affective disorders among patients hospitalised with adrenocortical insufficiency in the study period: 1977-1999. Method Using data from Danish registers, two study cohorts were identified by their ICD diagnoses at discharge from hospital: one comprising all patients with a first hospital admission with an index diagnosis of adrenocortical insufficiency; the other a control cohort comprising all patients with a first hospital admission with an index diagnosis of osteoarthritis. Subsequent admissions to psychiatric hospital wards with discharge ICD diagnoses of affective disorders were used as events of interest. Rates of readmission were estimated using Poisson regression models in survival analyses. Age, sex, duration of time after index discharge, and calendar time were included as co-variables. The primary analysis included all patients with adrenocortical insufficiency. Thereafter, the subgroup of patients with primary adrenocortical insufficiency (Addison's disease) was investigated separately in a secondary analysis. Results A study sample of 989 patients with adrenocortical insufficiency and 124,854 patients with osteoarthritis was identified. Eight hundred and fifty-two patients were subsequently readmitted with a diagnosis of affective disorder. Patients with adrenocortical insufficiency had a 2.68 (95% CI: 1.62-4.42) times greater rate of affective disorders and a 2.12 (95% CI: 1.16-3.86) times greater rate of depressive disorder…

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  • In retrospective and prospective studies the most frequent precipitating causes of adrenal crisis are gastroenteritis (35-45%) and fever (17-24%), but other stressful events such as trauma, surgery, dental procedures and major psychological distress can cause adrenal crisis.

    “In retrospective and prospective studies the most frequent precipitating causes of adrenal crisis are gastroenteritis (35–45%) and fever (17–24%),15,17,43 but other stressful events such as trauma,35 surgery,44 dental procedures45 and major psychological distress46 can cause adrenal crisis.”

    From Adrenal crisis: prevention and management in adult patients (2019) · cites this paper as [46]

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Authors
Thomsen, A. F., Kvist, T. K., Andersen, P. K., & Kessing, L. V.
Affiliations
  • Copenhagen University Hospital (DK)
  • University of Copenhagen (DK)
Corresponding author
Thomsen, Anders F.
ORCID
Kessing, Lars V.
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2006-06
Volume
31
Issue
5
Pages
614-622
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2006.01.003
OpenAlex
W2043735556
Cited by
79
References
10
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 14 · 2013: 2 · 2012: 2
FWCI
5.21
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
Lundbeckfonden
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords
adrenal insufficiency, Addison's disease, mood disorders, depressive disorders, psychiatric readmission, hydrocortisone replacement
MeSH terms
Addison Disease, Adolescent, Adrenal Cortex, Adrenal Insufficiency, Adult, Aged, Denmark, Depression, Female, Humans, Male, Middle Aged, Osteoarthritis, Regression Analysis, Risk Factors, Cohort Studies, Poisson Distribution, Mood Disorders

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