Double-blind treatment of major depression with dehydroepiandrosterone.
Abstract
OBJECTIVE: This study was designed to assess possible antidepressant effects of dehydroepiandrosterone (DHEA), an abundant adrenocortical hormone in humans. METHOD: Twenty-two patients with major depression, either medication-free or on stabilized antidepressant regimens, received either DHEA (maximum dose = 90 mg/day) or placebo for 6 weeks in a double-blind manner and were rated at baseline and at the end of the 6 weeks with the Hamilton Depression Rating Scale. Patients previously stabilized with antidepressants had the study medication added to that regimen; others received DHEA or placebo alone. RESULTS: DHEA was associated with a significantly greater decrease in Hamilton depression scale ratings than was placebo. Five of the 11 patients treated with DHEA, compared with none of the 11 given placebo, showed a 50% decrease or greater in depressive symptoms. CONCLUSIONS: These results suggest that DHEA treatment may have significant antidepressant effects in some patients with major depression. Further, larger-scale trials are warranted.
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Significant improvement in mood and well-being was observed in patients with major depression and midlife asthenia, whereas no effect was detected in perimenopausal women.
“A significant improvement in mood and well-being was observed in patients with major depression (331) and midlife asthenia (332), whereas no effect was detected in perimenopausal women (333).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [331]
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- Authors
- Wolkowitz, O. M., Reus, V. I., Keebler, A., Nelson, N., Friedland, M., Brizendine, L., & Roberts, E.
- Affiliations
- University of California, San Francisco (US)
- Venue
- American Journal of Psychiatry
- Published
- 1999-04-01
- Volume
- 156
- Issue
- 4
- Pages
- 646-649
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1922088893
- Cited by
- 411
- References
- 46
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 9 · 2019: 7 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 17 · 2013: 20 · 2012: 17
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- dehydroepiandrosterone, major depressive disorder, antidepressant effects, adrenal cortex hormones, Hamilton Depression Rating Scale, adjunctive therapy
- MeSH terms
- Adult, Antidepressive Agents, Dehydroepiandrosterone, Depressive Disorder, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Placebos, Psychiatric Status Rating Scales, Treatment Outcome
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