Treatment of Comorbid Tuberculosis and Depression
Open accessAbstract
Tuberculosis (TB) remains a leading infectious cause of mortality worldwide. While the overall prevalence of TB in the United States has declined in the general population, certain groups remain at high risk, including the homeless, those who are HIV seropositive, individuals with a history of alcohol or drug abuse, and immigrants from a country in which TB is endemic. Many recipients of psychiatric services possess 1 or more of these risk factors, and consequently TB may be overrepresented in this population. Conversely, psychiatric illness may develop subsequent to TB infection. Mood disorders seem to be particularly common in TB patients compared with those with other medical diagnoses. It is important that primary care physicians understand the high prevalence of mental illness in TB patients so that proper treatment provisions can be implemented. Likewise, it is important for psychiatrists to understand the clinical manifestations of TB so that when a patient presents with symptoms of TB proper precautions can be taken and appropriate referrals can be made. This article integrates information concerning mental illness in TB patients with diagnostic and treatment guidelines for TB. Brief suggestions are offered for the treatment of TB patients with comorbid mental illness.
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Pharmacological treatment of TB in depression is particularly challenging in view of significant interactions between ATT and antidepressants.
“Pharmacological treatment of TB in depression is particularly challenging in view of significant interactions between ATT and antidepressants.39”
From Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review (2021) · cites this paper as [39]
The treatment-concerns passage discusses potential interactions between isoniazid and antidepressants, supporting the need for care in treating comorbid TB and depression. But the Conclusion says there is no clinical evidence of interactions between isoniazid and any SSRI, so the claim overstates the interactions as significant and established. Page numbers are not available in our copy. (LLM, conf=0.88)
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- Authors
- Trenton, A. J., & Currier, G. W.
- Affiliations
- University of Rochester Medicine (US)
- Venue
- The Primary Care Companion For CNS Disorders
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2001-12-01
- Volume
- 3
- Issue
- 6
- Pages
- 236-243
- ISSN
- 2155-7772 (ISSN-L)
- 2155-7780
- PMC
- PMC181192
- OpenAlex
- W2044464525
- Cited by
- 48
- References
- 45
- Citations by year
- 2024: 4 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Primary Care Companion For CNS Disorders (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- tuberculosis, depression, comorbidities, mood disorders, tuberculosis risk factors, psychiatric referral, tuberculosis treatment guidelines, primary care
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