Cited by 141Stress Responses and CortisolChild and Adolescent Psychosocial and Emotional DevelopmentAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Alterations in HPA-axis and autonomic nervous system functioning in childhood anxiety disorders point to a chronic stress hypothesis

Open access

Dieleman, Gwendolyn C., Huizink, Anja C., Tulen, Joke H.M., Utens, Elisabeth M.W.J., Creemers, Hanneke E., van der Ende, Jan, Verhulst, Frank C.·2015·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2014.09.002

Open this paper in CoChat — free account Open PDF

Abstract

Background It is of debate whether or not childhood anxiety disorders (AD) can be captured by one taxonomic construct. This study examined whether perceived arousal (PA), autonomic nervous system (ANS) and hypothalamic-pituitary-adrenal (HPA) axis measures can distinguish children with different primary diagnoses of clinical anxiety disorders (AD) from each other, and from a general population reference group (GP).Methods The study sample consisted of 152 AD children (comparing separation anxiety disorder, generalized anxiety disorder, social phobia and specific phobia), aged 8- to 12-years, and 200 same-aged reference children. HPA-axis functioning was measured by a diurnal cortisol profile. ANS functioning was measured by continuous measures of skin conductance level in rest and during a mental arithmetic task and high frequency heart rate variability in rest. PA was assessed by a questionnaire.Results The AD sample showed lower high frequency heart rate variability during rest, heightened anticipatory PA, higher basal and reactive skin conductance levels and lower basal HPA-axis functioning compared to the GP sample. The existence of three or more clinical disorders, i.e. a high clinical 'load', was associated with lower basal HPA-axis functioning, higher skin conductance level and lower posttest PA. Specific phobia could be discerned from social phobia and separation anxiety disorder on higher skin conductance level.Conclusions Our findings indicated that children with AD have specific psychophysiological characteristics, which resemble the psychophysiological characteristics of chronic stress. A high clinical 'load' is associated with an altered ANS and HPA-axis functioning. Overall, ANS and HPA-axis functioning relate to AD in general, accept for specific phobia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.psyneuen.2014.09.002

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,421
The ‘Trier Social Stress Test’—a tool for investigating psychobiological stress responses in a laboratory setting
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000119004 · Cited by 6,093
Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research
Dickerson, S. S., & Kemeny, M. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.3.355 · Cited by 5,881
NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): Description, Differences From Previous Versions, and Reliability of Some Common Diagnoses
SHAFFER, D., FISHER, P., LUCAS, C. P., DULCAN, M. K., & SCHWAB-STONE, M. E. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200001000-00014 · Cited by 3,505
The Multidimensional Anxiety Scale for Children (MASC): factor structure, reliability, and validity
MARCH, J. S., PARKER, J. D. A., SULLIVAN, K., STALLINGS, P., & CONNERS, C. K. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199704000-00019 · Cited by 2,236
Rating scales to assess depression in school-aged children.
Kovács, M. (1981) · PubMed · Cited by 1,924
Endocrinology of the stress response
Charmandari, E., Tsigos, C., & Chrousos, G. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.120816 · Cited by 1,799
The Risk for Early-Adulthood Anxiety and Depressive Disorders in Adolescents With Anxiety and Depressive Disorders
Pine, D. S., Cohen, P., Gurley, D., Brook, J., & Ma, Y. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.1.56 · Cited by 1,753

Show all 50 references

Sorted by citations

Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
Michopoulos, V., Powers, A., Gillespie, C. F., Ressler, K. J., & Jovanovic, T. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.146 · Cited by 786
The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders
Smoller, J. W. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.266 · Cited by 516
Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition
Bandelow, B., Baldwin, D., Abelli, M., Bolea-Alamanac, B., Bourin, M., Chamberlain, S. R., Cinosi, E., Davies, S., Domschke, K., Fineberg, N., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1190867 · Cited by 347
Linking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience
Michelini, G., Palumbo, I. M., DeYoung, C. G., Latzman, R. D., & Kotov, R. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102025 · Cited by 304
Machine Learning Framework for the Detection of Mental Stress at Multiple Levels
Subhani, A. R., Mumtaz, W., Saad, M., Kamel, N., & Malik, A. S. (2017) · IEEE Access · doi:10.1109/access.2017.2723622 · Cited by 288
Human stress classification using EEG signals in response to music tracks
Asif, A., Majid, M., & Anwar, S. M. (2019) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2019.02.015 · Cited by 218
Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis
Sezer, I., Pizzagalli, D. A., & Sacchet, M. D. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104583 · Cited by 214
“While a growing number of studies have investigated therapeutic effects of mindfulness meditation for MDD (e.g., meta-analyzed in Goldberg et al., 2016), only one has investigated the effects of mindfulness meditation on rsFC in MDD. Specifically, Lifshitz and colleagues used a seed-based approach to compare MDD patie…”
BackgroundInfluential
Classification of Perceived Mental Stress Using A Commercially Available EEG Headband
Arsalan, A., Majid, M., Butt, A. R., & Anwar, S. M. (2019) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2019.2926407 · Cited by 198
Heart rate variability in patients with anxiety disorders: A systematic review and meta‐analysis
Cheng, Y., Su, M., Liu, C., Huang, Y., & Huang, W. (2022) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13356 · Cited by 205
Co-Occurring Alcohol Use Disorder and Anxiety: Bridging Psychiatric, Psychological, and Neurobiological Perspectives
Anker, J. J. (2019) · Alcohol research · doi:10.35946/arcr.v40.1.03 · Cited by 172
Understanding comorbidity among internalizing problems: Integrating latent structural models of psychopathology and risk mechanisms
Hankin, B. L., Snyder, H. R., Gulley, L. D., Schweizer, T. H., Bijttebier, P., Nelis, S., Toh, G. Y., & Vasey, M. W. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000663 · Cited by 172
Neurobiological and Hormonal Mechanisms Regulating Women’s Sleep
Dorsey, A., de Lecea, L., & Jennings, K. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.625397 · Cited by 100
The Role of the Oxytocin System in Anxiety Disorders
Yoon, S., & Kim, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9705-0_7 · Cited by 96
Psychosocial and biological risk factors of anxiety disorders in adolescents: a TRAILS report
Narmandakh, A., Roest, A. M., de Jonge, P., & Oldehinkel, A. J. (2020) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-020-01669-3 · Cited by 123
Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review
Tang, H.-Y., Jiang, A., Wang, X., Wang, H., Guan, Y., Li, F., & Shen, G.-M. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-2779 · Cited by 87
Much ado about much: Stress, dynamic biomarkers and HPA axis dysregulation along the trajectory to psychosis
Shah, J. L., & MALLA, A. K. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.01.010 · Cited by 78
Anxious parents show higher physiological synchrony with their infants
Smith, C. G., Jones, E. J. H., Charman, T., Clackson, K., Mirza, F. U., & Wass, S. V. (2021) · Psychological Medicine · doi:10.1017/s0033291720005085 · Cited by 73
Stress System Activation in Children and Adolescents With Autism Spectrum Disorder
Makris, G., Agorastos, A., Chrousos, G. P., & Pervanidou, P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.756628 · Cited by 66
Role of Nitric Oxide in Stress-Induced Anxiety
Kumar, A., & Chanana, P. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.09.004 · Cited by 59
Yoga for Depression and Anxiety: A Review of Published Research and Implications for Healthcare Providers.
Uebelacker, L. A., & Broughton, M. K. (2016) · PubMed · Cited by 49
Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview
Vismara, M. E. M., Girone, N., Cirnigliaro, G., Fasciana, F., Vanzetto, S., Ferrara, L., Priori, A., D’Addario, C., Viganò, C. A., & Dell’Osso, B. M. (2020) · Brain Sciences · doi:10.3390/brainsci10080564 · Cited by 48
Variability in emotional/behavioral problems in boys with oppositional defiant disorder or conduct disorder: the role of arousal
Schoorl, J., van Rijn, S., de Wied, M. A., van Goozen, S. H. M., & Swaab, H. (2015) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-015-0790-5 · Cited by 51
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure
Xu, B., Zang, S., Li, S., Guo, J., Wang, J., Wang, D., Zhang, L.-P., Yang, H.-M., & Lian, S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.313 · Cited by 47
Physiological Response to Social Evaluative Threat in Adolescents with Autism Spectrum Disorder
Edmiston, E. K., Jones, R. M., & Corbett, B. A. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2842-1 · Cited by 43
Assessing a hyperarousal hypothesis of insomnia in adults with autism spectrum disorder
Baker, E. K., Richdale, A. L., Hazi, A., & Prendergast, L. A. (2019) · Autism Research · doi:10.1002/aur.2094 · Cited by 42
Nausea in Children With Functional Abdominal Pain Predicts Poor Health Outcomes in Young Adulthood
Russell, A. C., Stone, A. L., & Walker, L. S. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.07.006 · Cited by 39
Associations between dehydroepiandrosterone (DHEA) levels, pituitary volume, and social anxiety in children
Murray, C., Simmons, J. G., Allen, N. B., Byrne, M. L., Mundy, L. K., Seal, M. L., Patton, G. C., Olsson, C. A., & Whittle, S. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.004 · Cited by 36
Parent-reported problematic sleep behaviors in children with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder
Reynolds, K. C., Patriquin, M. A., Alfano, C. A., Loveland, K. A., & Pearson, D. A. (2017) · Research in Autism · doi:10.1016/j.rasd.2017.04.003 · Cited by 37
A daily process examination of the relationship between childhood trauma and stress-reactivity
Weltz, S. M., Armeli, S., Ford, J. D., & Tennen, H. A. (2016) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2016.08.005 · Cited by 38
Anxiety and physiological responses to the Trier Social Stress Test for Children in adolescents with cyclic vomiting syndrome
Tarbell, S. E., Millar, A. M., Laudenslager, M. L., Palmer, C. E., & Fortunato, J. E. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.08.010 · Cited by 33
Prenatal betamethasone exposure and psychopathology risk in extremely low birth weight survivors in the third and fourth decades of life
Savoy, C. D., Ferro, M. A., Schmidt, L. A., Saigal, S., & Lieshout, R. J. V. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.021 · Cited by 33
Link between children’s hair cortisol and psychopathology or quality of life moderated by childhood adversity risk
Fuchs, A., Jaite, C., Neukel, C., Dittrich, K., Bertsch, K., Kluczniok, D., Möhler, E., Attar, C. H., Brunner, R. M., Bödeker, K., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.02.003 · Cited by 31
Yoga for Depression and Anxiety: A Review of Published Research and Implications for Healthcare Providers
Uebelacker, L. A., & Broughton, M. K. (2018) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.16104 · Cited by 32
Stress reactivity predicts symptom improvement in children with anxiety disorders
Dieleman, G. C., Huizink, A. C., Tulen, J. H. M., Utens, E. M. W. J., & Tiemeier, H. W. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.022 · Cited by 31
Self-citation
Increased neurokinin-1 receptor availability in the amygdala in social anxiety disorder: a positron emission tomography study with [11C]GR205171
Frick, A., Åhs, F., Linnman, C., Jonasson, M., Appel, L., Lubberink, M., Långström, B., Fredrikson, M., & Furmark, T. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.92 · Cited by 30
Maternal Separation Combined With Limited Bedding Increases Anxiety-Like Behavior and Alters Hypothalamic-Pituitary-Adrenal Axis Function of Male BALB/cJ Mice
Orso, R., Creutzberg, K. C., Kestering-Ferreira, É., Wearick‐Silva, L. E., Tractenberg, S. G., & Grassi‐Oliveira, R. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.600766 · Cited by 32
The blockade of corticotropin-releasing factor 1 receptor attenuates anxiety-related symptoms and hypothalamus–pituitary–adrenal axis reactivity in mice with mild traumatic brain injury
Kosari‐Nasab, M., Sadeghi, T., Bashiri, H., Shokouhi, G., & Salari, A. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000450 · Cited by 29
Neuroimmune Mechanisms and Sex/Gender-Dependent Effects in the Pathophysiology of Mental Disorders
Kokkosis, A. G., & Tsirka, S. E. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266163 · Cited by 29
The Effects of a Prenatal Mindfulness Intervention on Infant Autonomic and Behavioral Reactivity and Regulation
Noroña-Zhou, A. N., Coccia, M., Epel, E. S., Vieten, C., Adler, N. E., Laraia, B. A., Jones‐Mason, K., Alkon, A., & Bush, N. R. (2022) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001066 · Cited by 28
The Volatile Oil of Zanthoxylum bungeanum Pericarp Improved the Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota to Attenuate Chronic Unpredictable Stress-Induced Anxiety Behavior in Rats
Wei, D., Zhao, Y., Zhang, M., Zhu, L., Wang, L., Yuan, X., & Wu, C. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s281575 · Cited by 28
Repeated stress leads to enhanced cortisol stress response in child social anxiety disorder but this effect can be prevented with CBT
Asbrand, J., Heinrichs, N., Nitschke, K., Wolf, O. T., Schmidtendorf, S., & Tuschen‐Caffier, B. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.06.003 · Cited by 25
The Brain-Gut Team
Malagelada, J. R. (2020) · Digestive Diseases · doi:10.1159/000505810 · Cited by 24
Aroused at Home: Basic Autonomic Regulation during Orthostatic and Physical Activation is Altered in Children with Social Anxiety Disorder
Asbrand, J., Blechert, J., Nitschke, K., Tuschen‐Caffier, B., & Schmitz, J. (2016) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-016-0147-7 · Cited by 26
A neurobiological framework of separation anxiety and related phenotypes
Schiele, M. A., Bandelow, B., Baldwin, D. S., Pini, S., & Domschke, K. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.01.009 · Cited by 23
The psychosomatic impact of Yoga in medical education: a systematic review and meta-analysis
Maity, S., Abbaspour, R., Bandelow, S., Pahwa, S., Alahdadi, T., Shah, S., Chhetri, P., Jha, A. K., Nauhria, S., Nath, R., et al. (2024) · Medical Education Online · doi:10.1080/10872981.2024.2364486 · Cited by 23
Classification of Mental Stress Levels by Analyzing fNIRS Signal Using Linear and Non-linear Features
Shirvan, R. A., Setarehdan, S. K., & Nasrabadi, A. M. (2018) · International Clinical Neuroscience Journal · doi:10.15171/icnj.2018.11 · Cited by 23
Negative affect reactivity to stress and internalizing symptoms over the transition to college for Latinx adolescents: Buffering role of family support
Anderson, S. F., Sladek, M. R., & Doane, L. D. (2020) · Development and Psychopathology · doi:10.1017/s095457942000053x · Cited by 24
Candidate Biological Markers for Social Anxiety Disorder: A Systematic Review
Caldiroli, A., Capuzzi, E., Affaticati, L. M., Surace, T., Forti, C. L. D., Dakanalis, A., Clerici, M., & Buoli, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010835 · Cited by 27
Functional Nausea in Children: A Review of the Literature and Need for Diagnostic Criteria
Russell, A. C., Stone, A. L., & Walker, L. S. (2016) · Children · doi:10.3390/children3010005 · Cited by 22
Connecting chronic stress and anxiety: a multi-dimensional perspective
Hussenoeder, F. S., Conrad, I., Pabst, A., Engel, C., Zachariae, S., Zeynalova, S., Yahiaoui‐Doktor, M., Glaesmer, H., Hinz, A., Witte, A. V., et al. (2022) · Psychology Health & Medicine · doi:10.1080/13548506.2022.2124292 · Cited by 23
Associations Between Asthma and Polycystic Ovary Syndrome: Current Perspectives
Xu, Y., Zhou, Z., Pan, J., & Huang, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.936948 · Cited by 19
Seeing but Not Feeling: Machiavellian Traits in Relation to Physiological Empathetic Responding and Life Experiences
Massey-Abernathy, A. R., & Byrd‐Craven, J. (2016) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-016-0041-0 · Cited by 19
Trajectories of Heart Activity Across Infancy to Early Childhood Differentially Predict Autism and Anxiety Symptoms in Fragile X Syndrome
Hogan, A. L., Hunt, E. E., Smith, K., Black, C. J., Bangert, K. J., Klusek, J., & Roberts, J. E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.727559 · Cited by 21
Prenatal Maternal Distress: A Risk Factor for Child Anxiety?
McLean, M. A., Cobham, V. E., & Simcock, G. P. (2018) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-017-0251-4 · Cited by 22
The influence of genes on “positive valence systems” constructs: A systematic review
Hess, J., Kawaguchi, D. M., Wagner, K. E., Faraone, S. V., & Glatt, S. J. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32382 · Cited by 18
Anxiogenic-like effects of fluoxetine render adult male rats vulnerable to the effects of a novel stress
Gómez-Oliver, F., & García‐García, L. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.12.007 · Cited by 18
Anxiety, hostile attributions, and differences in heart rate response to ambiguous situational vignettes in adolescents.
Banks, D. M., Scott, B. G., & Weems, C. F. (2017) · Emotion · doi:10.1037/emo0000352 · Cited by 18
ADHD symptoms and diurnal cortisol in adolescents: The importance of comorbidities
Berens, A. E., LeMoult, J., Kircanski, K., & Gotlib, I. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105990 · Cited by 15
Physiological correlates of anxiety in childhood and adolescence: A systematic review and meta‐analysis
Ko, K. Y., Jones, A., Francis, D. A., Robidoux, S., & McArthur, G. M. (2024) · Stress and Health · doi:10.1002/smi.3388 · Cited by 18
Patterns of joint parasympathetic, sympathetic, and adrenocortical activity and their associations with temperament in early childhood
Kołacz, J., Holochwost, S. J., Gariépy, J., & Mills-Koonce, R. (2016) · Developmental Psychobiology · doi:10.1002/dev.21429 · Cited by 14
Eye-movement indices of arousal predict ADHD and comorbid externalizing symptoms over a 2-year period
Kleberg, J. L., Frick, M. A., & Brocki, K. C. (2023) · Scientific Reports · doi:10.1038/s41598-023-31697-3 · Cited by 14
Parental overcontrol x OPRM1 genotype interaction predicts school-aged children’s sympathetic nervous system activation in response to performance challenge
Partington, L. C., Borelli, J. L., Smiley, P. A., Jarvik, E. R., Rasmussen, H. F., Seaman, L. C., & Nurmi, E. L. (2018) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2018.04.011 · Cited by 12
Sex-specific associations between person and environment-related childhood adverse events and levels of cortisol and DHEA in adolescence
van Dammen, L., de Rooij, S. R., Behnsen, P., & Huizink, A. C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233718 · Cited by 13
Self-citation
Hippocampal interneurons are direct targets for circulating glucocorticoids
Kraus, K. L., Chordia, A. P., Drake, A. W., Herman, J. P., & Danzer, S. C. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25322 · Cited by 14
Compromised dynamic cerebral autoregulation in patients with generalized anxiety disorder: a study using transfer function analysis
Guo, Z., Lv, S., Liu, J., Wang, Z., Jin, H., Qiu, Q., Sun, X., & Yang, Y. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1713-z · Cited by 13
Psychophysiological mechanisms underlying the failure to speak: a comparison between children with selective mutism and social anxiety disorder on autonomic arousal
Vogel, F., & Schwenck, C. (2021) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-021-00430-1 · Cited by 12
Inducing and Assessing Acute Mental Stress in Controlled Conditions: Topical Review and Guidelines for Effective Experimental Protocols
Raggi, M., Moore, L. J., & Mesin, L. (2025) · IEEE Access · doi:10.1109/access.2025.3528518 · Cited by 14
How children's anxiety symptoms impact the functioning of the hypothalamus–pituitary–adrenal axis over time: A cross-lagged panel approach using hierarchical linear modeling
Ma, D., Serbin, L. A., & Stack, D. M. (2018) · Development and Psychopathology · doi:10.1017/s0954579417001870 · Cited by 14
Stress reactivity in healthy child offspring of parents with anxiety disorders
Koszycki, D., Taljaard, M., Bielajew, C. H., Gow, R. M., & Bradwejn, J. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.171 · Cited by 12
Salivary alpha amylase levels in youths with anxiety disorders.
Yorbik, O., Mutlu, C., Ozturk, O., Altinay, D. K., Tanju, I., & Kurt, Í. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2015.11.021 · Cited by 13
Intranasal oxytocin as a treatment for anxiety and autism: From subclinical to clinical applications
Yin, H., Jiang, M., Han, T., & Xu, X. (2024) · Peptides · doi:10.1016/j.peptides.2024.171211 · Cited by 11
Mental health consequences of early life stress in children – The autonomic nervous system as a potential target for early detection and intervention?
Venn, R., Sigrist, C., Rudzki, S. J., D'Cunha, N. M., Buchhorn, R., Koenig, J., Northey, J. M., Naumovski, N., & McKune, A. J. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107505 · Cited by 14
Increased Hippocampal Glucocorticoid Receptor Expression and Reduced Anxiety-Like Behavior Following Tuina in a Rat Model With Allergic Airway Inflammation
Liu, Y., Cao, L.-Y., Liu, J., Zhang, Z., Fan, P., Zhu, Y., Zhang, S., Gu, Y., Li, Q., & Xiong, Y. (2022) · Journal of Manipulative and Physiological Therapeutics · doi:10.1016/j.jmpt.2023.04.008 · Cited by 11
The children of Superstorm Sandy: Maternal prenatal depression blunts offspring electrodermal activity
Buthmann, J. L., Finik, J. M., Ventura, G., Zhang, W., Shereen, A. D., & Nomura, Y. (2019) · Biological Psychology · doi:10.1016/j.biopsycho.2019.107716 · Cited by 10
Peri-adolescent asthma: Acute impacts on innate immune response, corticosterone, and microglia in mice
Caulfield, J. I., Schopf, K. J., & Cavigelli, S. A. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577450 · Cited by 11
Randomized Crossover Study of Auricular Plaster Therapy to Relieve Dental Anxiety in Children
Wang, J., Zhang, J., & Sun, D. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.862575 · Cited by 11
Functional neurological disorder, physical activity and exercise: What we know and what we can learn from comorbid disorders
Boylan, K. A., Dworetzky, B. A., Baslet, G. C., Polich, G. R., O’Neal, M. A., & Reinsberger, C. (2024) · Epilepsy & Behavior Reports · doi:10.1016/j.ebr.2024.100682 · Cited by 10
Perceived Coping Mitigates Anxiety Symptoms in the Context of COVID-19 Stress in an Urban University Student Sample
Rudenstine, S., Schulder, T., Ettman, C. K., & Galea, S. (2022) · Psychological Reports · doi:10.1177/00332941221074038 · Cited by 10
Perinatal diet and offspring anxiety: A scoping review
Monteiro, S., Nejad, Y. S., & Aucoin, M. (2022) · Translational Neuroscience · doi:10.1515/tnsci-2022-0242 · Cited by 10
The role of the endogenous oxytocin system under psychosocial stress conditions in adolescents suffering from anxiety disorder: study protocol for a parallel group controlled trial
Goetz, L., Jarvers, I., Schleicher, D., Mikan, K., Brunner, R. M., & Kandsperger, S. (2021) · BMC Psychology · doi:10.1186/s40359-021-00564-z · Cited by 10
Are carriers ofCYP21A2mutations less vulnerable to psychological stress? A population-based national cohort study
Nordenström, A., Butwicka, A., Hirschberg, A. L., Almqvist, C., Nordenskjöld, A., Falhammar, H., & Frisén, L. (2016) · Clinical Endocrinology · doi:10.1111/cen.13242 · Cited by 9
Endogenous in-session cortisol during exposure therapy predicts symptom improvement: Preliminary results from a scopolamine-augmentation trial
Kuhlman, K. R., Treanor, M., Imbriano, G., & Craske, M. G. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104657 · Cited by 10
Heart rate (variability) and the association between relational peer victimization and internalizing symptoms in elementary school children
Behnsen, P., Buil, J. M., Koot, S., Huizink, A. C., & van Lier, P. A. C. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000269 · Cited by 9
Self-citation
Modern Trends of the Development of Primary School-Aged Children (Literature Review)
Chanchaeva, E. A., Айзман, Р. И., Sidorov, S. S., Popova, E. V., & Simonova, O. I. (2019) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2019-4.1.9 · Cited by 8
Resting respiratory sinus arrhythmia moderates the association between social phobia symptoms and self‐reported physical symptoms
Xing, W., Lu, W. D., & Wang, Z. (2019) · Stress and Health · doi:10.1002/smi.2885 · Cited by 8
Impact of Music in Males and Females for Relief from Neurodegenerative Disorder Stress
Salankar, N., Mishra, A., Koundal, D., Hoang, V. T., Tran-Trung, K., Zaguia, A., & Belay, A. (2022) · Contrast Media & Molecular Imaging · doi:10.1155/2022/3080437 · Cited by 8
An emotion regulation skills training for adolescents and parents: perceptions and acceptability of methodological aspects
Holmqvist Larsson, K., & Zetterqvist, M. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1448529 · Cited by 7
“…neurodiversity, can experience dif ﬁ culties with establishing and maintaining routines for sleep, food, physical exercise and positive activities, as well as balancing stress and rest (48, 49), making them more emotionally vulnerable and potentially less well-equipped to face life challenges (50).”
Early physiological indicators of narcissism and self‐esteem in children
Brummelman, E., Nikolić, M., Nevicka, B., & Bögels, S. M. (2022) · Psychophysiology · doi:10.1111/psyp.14082 · Cited by 7
Unique contributions of anxiety, stress and depression to immunity: A cross-cultural investigation
Breeze, C., Medvedev, O. N., Cervin, M., Sutton, A., Barcaccia, B., Couyoumdjian, A., Pallini, S., Billot, M., Chalmers, R., Iqbal, N., et al. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100699 · Cited by 7
The relationship between depression severity and heart rate variability in children and adolescents: A meta-analysis
Ding, J., Wu, Y., Wang, B., & Sun, Z. (2024) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2024.111804 · Cited by 7
Mechanism-Oriented Therapy of Irritable Bowel Syndrome
Malagelada, J. R., & Malagelada, C. (2016) · Advances in Therapy · doi:10.1007/s12325-016-0336-3 · Cited by 7
Ansiedad, depresión y actividad autónoma en estudiantes de enfermería, en el estado de Guanajuato, México
Palacios, G. R., Guerra, A. G., Sansores, G. M. Á., & Aguila, P. I. D. S. G. (2020) · Revista Digital Internacional de Psicología y Ciencia Social · doi:10.22402/j.rdipycs.unam.6.1.2020.212.81-103 · Cited by 7
Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress
de Sousa, M. B. C., Grilo, M. L. P. D. M., & Coelho, N. L. G. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.674256 · Cited by 8
The Association of Anxiety Severity With Health Risk Behaviors in a Large Representative Sample of Korean Adolescents
Woo, K. S., Ji, Y., Lee, H. J., & Choi, T. Y. (2021) · Journal of korean Academy of Child and Adolescent Psychiatry · doi:10.5765/jkacap.210017 · Cited by 10
Social media communication and public engagement in different health crisis stages: The framing of COVID-19 in Chinese official media
Lu, W., & Ngai, C. S. B. (2024) · Communication and the Public · doi:10.1177/20570473241246291 · Cited by 6
Evidence of Differential Prediction of Anxiety and Depression by Diurnal Alpha‐Amylase and Cortisol in Development
McCurdy, B. H., Weems, C. F., Bradley, T., Matlow, R. B., & Carrión, V. G. (2024) · Developmental Psychobiology · doi:10.1002/dev.22549 · Cited by 6
Peculiarities of correlation between cognitive parameters and anxiety and self-assessment levels in year-1 schoolchildren within the polycultural environment
Chanchaeva, E. A., Sidorov, S. S., Ostapovich, O. V., & Айзман, Р. И. (2019) · Science for Education Today · doi:10.15293/2658-6762.1903.14 · Cited by 6
How Peers and Teachers Shape Elementary School Children’s Academic and Socioemotional Development
Vitaro, F., Colpin, H., Tieskens, J. M., & van Lier, P. A. C. (2022) · Springer eBooks · doi:10.1007/978-3-031-07109-6_3 · Cited by 7
TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda
Kalungi, A., Kinyanda, E., Womersley, J. S., Joloba, M. L., Ssembajjwe, W. J., Nsubuga, R. N., Kaleebu, P., Levin, J. B., Kidd, M., Seedat, S., et al. (2021) · BMC Medical Genomics · doi:10.1186/s12920-020-00857-z · Cited by 6
Intranasal Oxytocin Administration Reduces Bystanders’ Acceptance of Online Celebrity Bashing
Rudnicki, K., Ouvrein, G., Backer, C. J. S. D., & Vandebosch, H. (2019) · International Journal of Bullying Prevention · doi:10.1007/s42380-019-00054-2 · Cited by 5

Authors: Dieleman, G. C., Huizink, A. C., Tulen, J. H. M., Utens, E. M. W. J., Creemers, H. E., van der Ende, J., & Verhulst, F. C.
Affiliations: Erasmus MC (NL)
Vrije Universiteit Amsterdam (NL)
University of Amsterdam (NL)
Corresponding author: Dieleman, Gwendolyn C.
ORCID: Dieleman, Gwendolyn C.
Huizink, Anja C.
Tulen, Joke H.M.
Utens, Elisabeth M.W.J.
Creemers, Hanneke E.
Verhulst, Frank C.
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2015-01
Volume: 51
Pages: 135-150
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2014.09.002
OpenAlex: W2118182252
Cited by: 141
References: 50
Citations by year: 2026: 7 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 19 · 2021: 14 · 2020: 15 · 2019: 15 · 2018: 11 · 2017: 4 · 2016: 19 · 2015: 10
FWCI: 5.38
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion, other-oa)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
VU Research Portal (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: childhood anxiety disorders, hypothalamic-pituitary-adrenal axis, autonomic nervous system, cortisol, skin conductance, heart rate variability, perceived arousal, separation anxiety disorder, generalized anxiety disorder, social anxiety disorder, specific phobia, psychophysiology
MeSH terms: Anxiety Disorders, Autonomic Nervous System, Child, Circadian Rhythm, Diagnosis, Differential, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Surveys and Questionnaires, Saliva, Stress, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alterations in HPA-axis and autonomic nervous system functioning in childhood anxiety disorders point to a chronic stress hypothesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks