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Cited by 27Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

D1 receptors regulate dendritic morphology in normal and stressed prelimbic cortex

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Lin, Grant L., Borders, Candace B., Lundewall, Leslie J., Wellman, Cara L.·2015·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2014.09.020PMC PMC4268137
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Abstract

Both stress and dysfunction of prefrontal cortex are linked to psychological disorders, and structure and function of medial prefrontal cortex (mPFC) are altered by stress. Chronic restraint stress causes dendritic retraction in the prelimbic region (PL) of mPFC in rats. Dopamine release in mPFC increases during stress, and chronic administration of dopaminergic agonists results in dendritic remodeling. Thus, stress-induced alterations in dopaminergic transmission in PL may contribute to dendritic remodeling. We examined the effects of dopamine D1 receptor (D1R) blockade in PL during daily restraint stress on dendritic morphology in PL. Rats either underwent daily restraint stress (3h/day, 10 days) or remained unstressed. In each group, rats received daily infusions of either the D1R antagonist SCH23390 or vehicle into PL prior to restraint; unstressed and stressed rats that had not undergone surgery were also examined. On the final day of restraint, rats were euthanized and brains were processed for Golgi histology. Pyramidal neurons in PL were reconstructed and dendritic morphology was quantified. Vehicle-infused stressed rats demonstrated dendritic retraction compared to unstressed rats, and D1R blockade in PL prevented this effect. Moreover, in unstressed rats, D1R blockade produced dendritic retraction. These effects were not due to attenuation of the HPA axis response to acute stress: plasma corticosterone levels in a separate group of rats that underwent acute restraint stress with or without D1R blockade were not significantly different. These findings indicate that dopaminergic transmission in mPFC during stress contributes directly to the stress-induced retraction of apical dendrites, while dopamine transmission in the absence of stress is important in maintaining normal dendritic morphology.

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  • Remaining dopamine release appears sufficient for detrimental actions, as D1R blockade during chronic stress prevents dendritic retraction in rat PFC.

    “However, remaining dopamine release appears sufficient for detrimental actions, as D1R blockade during chronic stress prevents dendritic retraction in rat PFC92.”

    From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [92]

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Authors
Lin, G. L., Borders, C. B., Lundewall, L. J., & Wellman, C. L.
Affiliations
Indiana University Bloomington (US)
Corresponding author
Wellman, Cara L.
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2015-01
Volume
51
Pages
101-111
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2014.09.020
PMC
PMC4268137
OpenAlex
W2024931618
Cited by
27
References
11
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1
FWCI
1.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (MHR03087794)
  • Indiana University
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dopamine D1 receptor, dendritic morphology, dendritic retraction, prelimbic cortex, medial prefrontal cortex, chronic restraint stress, dopamine signaling, pyramidal neurons, hypothalamic-pituitary-adrenal axis, corticosterone, mental illness
MeSH terms
Animals, Benzazepines, Dendrites, Male, Neurons, Restraint, Physical, Stress, Physiological, Stress, Psychological, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Dopamine D1, Dopamine Antagonists, Cell Shape, Rats

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