Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses
Open accessAbstract
This review describes unique neuromodulatory influences on working memory prefrontal cortical (PFC) circuits that coordinate cognitive strength with arousal state. Working memory arises from recurrent excitation within layer III PFC pyramidal cell NMDA circuits, which are afflicted in aging and schizophrenia. Neuromodulators rapidly and flexibly alter the efficacy of these synaptic connections, while leaving the synaptic architecture unchanged, a process called dynamic network connectivity (DNC). Increases in calcium-cAMP signaling open ion channels in long, thin spines, gating network connections. Inhibition of calcium-cAMP signaling by stimulating α2A-adrenoceptors on spines strengthens synaptic efficacy and increases network firing, whereas optimal stimulation of dopamine D1 receptors sculpts network inputs to refine mental representation. Generalized increases in calcium-cAMP signaling during fatigue or stress disengage dlPFC recurrent circuits, reduce firing and impair top-down cognition. Impaired DNC regulation contributes to age-related cognitive decline, while genetic insults to DNC proteins are commonly linked to schizophrenia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In human and rhesus monkey dlPFC, DISC1 is located in layer III spines, where it anchors PDE4A next to the spine apparatus, positioned to regulate feedforward cAMP-Ca2+ stress signaling pathways.
“Immunoelectron microscopy studies of human126 and rhesus monkey13,127 dlPFC show that DISC1 is located in layer III spines, where it anchors PDE4A next to the spine apparatus, critically positioned to regulate feedforward cAMP–Ca2+ stress signaling pathways13,127.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [13]
In “Mechanisms that strengthen synaptic efficacy” (page not supplied), the paper places DISC1 and PDE4A together near the spine apparatus in monkey layer III dlPFC spines and suggests they regulate cAMP–Ca2+ signaling. “Genetic insults in schizophrenia” (page not supplied) likewise describes immunoelectron microscopy findings in monkey dlPFC, but neither passage establishes the claimed localization in human dlPFC. The paper also calls DISC1’s anchoring of PDE4A likely, rather than demonstrated. (LLM, conf=0.88)
Experimental — accuracy not yet measuredExposure to stress disrupts prefrontal cortex function, markedly impairing working memory.
“Exposure to stress, however, can disrupt PFC function, markedly impairing working memory (Arnsten, 2009; Arnsten et al., 2012).”
From Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex (2013) · cites this paper as Arnsten et al., 2012
In dlPFC working memory circuits, cAMP-PKA signaling opens nearby K+ channels to rapidly weaken synaptic strength and reduce Delay cell firing.
“In these circuits, cAMP-PKA signaling opens nearby potassium (K+) channels to rapidly weaken synaptic strength and reduce Delay cell firing (Fig. 3C; (Arnsten et al., 2012)).”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Arnsten et al., 2012
Layer III dlPFC microcircuits have unique molecular needs for neurotransmission and neuromodulation that allow them to sustain long periods of neuronal firing without bottom-up sensory stimulation.
“Layer III dlPFC microcircuits that generate mental representations have unique molecular needs for both neurotransmission and neuromodulation that allow them to sustain long periods of neuronal firing without bottom-up sensory stimulation (Arnsten, 2015, Arnsten et al., 2012).”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Arnsten et al., 2012
These very rapid changes in synapse strength, called dynamic network connectivity, are mediated by feedforward, cAMP-Ca2+ signaling, which opens K+ channels (HCN, KCNQ) near the synapse to weaken the connection.
“These very rapid changes in synapse strength, called dynamic network connectivity13, are mediated by feedforward, cAMP–Ca2+ signaling, which opens K+ channels (HCN, KCNQ) near the synapse to weaken the connection.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [13]
Physiological, behavioral and immunoelectron microscopic evidence suggest that these pathways interact: feedforward Ca2+-cAMP signaling opens nearby HCN and KCNQ K+ channels to weaken the efficacy of nearby NMDAR synaptic connections.
“Physiological, behavioral and immunoelectron microscopic evidence suggest that these pathways interact: feedforward Ca2+–cAMP signaling opens nearby HCN and KCNQ K+ channels to weaken the efficacy of nearby NMDAR synaptic connections13.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [13]
The inverted U relationship between stress and PFC performance depends on the level of release of neuromodulators such as dopamine and norepinephrine.
“Pharmacological investigations indicate that this relationship depends upon the level of release of neuromodulators, such as dopamine and norepinephrine (Arnsten, 2009; Arnsten et al., 2012).”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Arnsten et al., 2012
Activation of receptors for these neuromodulators at intermediate levels may enhance performance on PFC-dependent tasks, whereas further increases may impair behavioral performance and reduce neural representation in the PFC.
“Activation of receptors for these neuromodulators at intermediate levels may enhance performance on PFC dependent tasks, whereas further increases may result in a decrement in behavioral performance and reduced neural representation of that performance in the PFC (reviewed in (Arnsten, 2009; Arnsten et al., 2012)).”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Arnsten et al., 2012
In tasks requiring prefrontal cortical function, there is an inverted U relationship between stress and performance.
“In tasks that require prefrontal cortical (PFC) function, there is an inverted U relationship between stress and performance.”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Arnsten et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376 · see citing works
Receptive fields of single neurones in the cat's striate cortex
Hubel, D. H., & Wiesel, T. N. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006308 · Cited by 4,653 · see citing works
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works
Self-citationMnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685 · see citing works
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663 · see citing works
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396 · see citing works
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960 · see citing works
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901 · see citing works
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636 · see citing works
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593 · see citing works
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500 · see citing works
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity
Yuste, R., & Bonhoeffer, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1071 · Cited by 1,269 · see citing works
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
Frey, U., Huang, Y.-Y., & Kandel, E. R. (1993) · Science · doi:10.1126/science.8389057 · Cited by 1,218 · see citing works
Abel, T., Nguyen, P. V., Barad, M., Deuel, T. A. S., Kandel, E. R., & Bourtchouladze, R. (1997) · Cell · doi:10.1016/s0092-8674(00)81904-2 · Cited by 1,217 · see citing works
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).
Luscher, C., & Malenka, R. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005710 · Cited by 1,110 · cited 1× · see citing works
“Long-term plastic changes begin with relatively rapid alterations in the numbers of AMPA and NMDA receptors in the synapse (Lü scher and Malenka, 2012), leading to structural changes, such as enlarging of the spine head and shortening/thickening of the spine neck (Yuste and Bonhoeffer, 2001) to…”
Single neurons in prefrontal cortex encode abstract rules
Wallis, J. D., Anderson, K. C., & Miller, E. K. (2001) · Nature · doi:10.1038/35082081 · Cited by 1,075 · see citing works
Goldman-Rakic, P. S. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0129 · Cited by 1,072 · see citing works
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., & Arnsten, A. F. T. (2007) · Nature Neuroscience · doi:10.1038/nn1846 · Cited by 1,013 · see citing works
Self-citationListon, C., Miller, M. M., Goldwater, D. S., Radley, J. J., Rocher, A. B., Hof, P. R., Morrison, J. H., & McEwen, B. S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1184-06.2006 · Cited by 968 · see citing works
The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation
Robbins, T. W., & Arnsten, A. F. T. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135535 · Cited by 957 · see citing works
Self-citationThe reduced neuropil hypothesis: a circuit based model of schizophrenia
Selemon, L. D., & Goldman-Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00281-9 · Cited by 909 · see citing works
Selemon, L. D., & Goldman-Rakic, P. S. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04049.1988 · Cited by 908 · see citing works
Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory
Wang, X.-J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09587.1999 · Cited by 859 · see citing works
Liu, Y., Wong, T. P., Aarts, M., Rooyakkers, A., Liu, L., Lai, T. W., Wu, D. C., Lu, J., Tymianski, M., Craig, A. M., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0116-07.2007 · Cited by 773 · see citing works
Chronic stress alters dendritic morphology in rat medial prefrontal cortex
Cook, S. C., & Wellman, C. L. (2004) · Journal of Neurobiology · doi:10.1002/neu.20025 · Cited by 750 · see citing works
Ross, C. A., Margolis, R. L., Reading, S. A. J., Pletnikov, M. V., & Coyle, J. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.015 · Cited by 697 · see citing works
Pathways modulating neural KCNQ/M (Kv7) potassium channels
Delmas, P., & Brown, D. A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1785 · Cited by 686 · see citing works
Qin, S., Hermans, E. J., van Marle, H. J. F., Luo, J., & Fernández, G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.006 · Cited by 675 · see citing works
Wang, M., Ramos, B. P., Paspalas, C. D., Shu, Y., Simen, A., Duque, A., Vijayraghavan, S., Brennan, A., Dudley, A., Nou, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.015 · Cited by 672 · see citing works
Self-citationDo Rats Have Prefrontal Cortex? The Rose-Woolsey-Akert Program Reconsidered
Preuss, T. M. (1995) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1995.7.1.1 · Cited by 666 · see citing works
DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling
Millar, J. K., Pickard, B. S., Mackie, S., James, R., Christie, S., Buchanan, S. R., Malloy, M. P., Chubb, J. E., Huston, E., Baillie, G. S., et al. (2005) · Science · doi:10.1126/science.1112915 · Cited by 648 · see citing works
Relation of Prefrontal Cortex Dysfunction to Working Memory and Symptoms in Schizophrenia
Perlstein, W. M., Carter, C. S., Noll, D. C., & Cohen, J. D. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1105 · Cited by 647 · see citing works
Scahill, L., Chappell, P. B., Kim, Y. S., Schultz, R. T., Katsovich, L., Shepherd, E., Arnsten, A. F. T., Cohen, D. J., & Leckman, J. F. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1067 · Cited by 588 · see citing works
Self-citationDopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys
Arnsten, A. F. T., Cai, J. X., Murphy, B. L., & Goldman-Rakic, P. S. (1994) · Psychopharmacology · doi:10.1007/bf02245056 · Cited by 566 · see citing works
Self-citationCortex and memory: emergence of a new paradigm
Fuster, J. M. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21280 · Cited by 559 · see citing works
Krystal, J. H., D'Souza, D. C., Mathalon, D., Perry, E., Belger, A., & Hoffman, R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1582-z · Cited by 530 · see citing works
Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy
Schroeder, B. C., Kubisch, C., Stein, V., & Jentsch, T. J. (1998) · Nature · doi:10.1038/25367 · Cited by 520 · see citing works
Fuster, J. M. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01128-4 · Cited by 516 · see citing works
Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons
Seamans, J. K., Gorelova, N., Durstewitz, D., & Yang, C. R. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03628.2001 · Cited by 507 · see citing works
Huang, Y.-Y., Li, X.-C., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90401-4 · Cited by 490 · see citing works
Neuronal basis of age-related working memory decline
Wang, M., Gamo, N. J., Yang, Y., Jin, L. E., Wang, X.-J., Laubach, M., Mazer, J. A., Lee, D., & Arnsten, A. F. T. (2011) · Nature · doi:10.1038/nature10243 · Cited by 485 · see citing works
Self-citationForward frontal fields: phylogeny and fundamental function
Wise, S. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.08.008 · Cited by 478 · cited 1× · see citing works
“Evolutionary Influences on Deep Layer III Microcircuitry The dlPFC expands greatly over evolution, with no exact counterpart in rodents, and an enormous extension from nonhuman to human primates (Elston, 2003; Elston et al., 2006; Preuss, 1995; Wise, 2008).”
A Behavioral Role for Dendritic Integration
Nolan, M. F., Malleret, G., Dudman, J. T., Buhl, D. L., Santoro, B., Gibbs, E., Vronskaya, S., Buzsáki, G., Siegelbaum, S. A., Kandel, E. R., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.020 · Cited by 472 · see citing works
Disrupted prediction-error signal in psychosis: Evidence for an associative account of delusions
Corlett, P. R., Murray, G. K., Honey, G. D., Aitken, M. R. F., Shanks, D. R., Robbins, T. W., Bullmore, E. T., Dickinson, A., & Fletcher, P. C. (2007) · Brain · doi:10.1093/brain/awm173 · Cited by 460 · see citing works
Decreased Brain Volume in Adults with Childhood Lead Exposure
Cecil, K. M., Brubaker, C. J., Adler, C. M., Dietrich, K. N., Altaye, M., Egelhoff, J. C., Wessel, S., Elangovan, I., Hornung, R., Jarvis, K., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050112 · Cited by 458 · see citing works
Devaux, J. J., Kleopa, K. A., Cooper, E. C., & Scherer, S. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4512-03.2004 · Cited by 451 · see citing works
Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
Mirnics, K., Middleton, F. A., Stanwood, G. D., Lewis, D. A., & Levitt, P. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000866 · Cited by 446 · see citing works
Picomolar concentrations of lead stimulate brain protein kinase C
Markovac, J., & Goldstein, G. W. (1988) · Nature · doi:10.1038/334071a0 · Cited by 440 · see citing works
Cortex, Cognition and the Cell: New Insights into the Pyramidal Neuron and Prefrontal Function
Elston, G. N. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg093 · Cited by 440 · see citing works
Dumitriu, D., Hao, J., Hara, Y., Kaufmann, J., Janssen, W. G. M., Lou, W., Rapp, P. R., & Morrison, J. H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6410-09.2010 · Cited by 439 · see citing works
Levinson, D. F., Duan, J., Oh, S., Wang, K., Sanders, A. R., Shi, J., Zhang, N., Mowry, B. J., Olincy, A., Amin, F., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10060876 · Cited by 434 · see citing works
Finlay, J. M., Zigmond, M. J., & Abercrombie, E. D. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00331-x · Cited by 434 · see citing works
Linking neurodevelopmental and synaptic theories of mental illness through DISC1
Brandon, N. J., & Sawa, A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3120 · Cited by 422 · see citing works
Chen, S., Wang, J., & Siegelbaum, S. A. (2001) · The Journal of General Physiology · doi:10.1085/jgp.117.5.491 · Cited by 416 · see citing works
Liu, R.-J., Lee, F. S., Li, X.-Y., Bambico, F., Duman, R. S., & Aghajanian, G. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.030 · Cited by 403 · see citing works
Seamans, J. K., Durstewitz, D., Christie, B. R., Stevens, C. F., & B, T. J. S. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.301 · Cited by 399 · see citing works
Activity-dependent decrease of excitability in rat hippocampal neurons through increases in Ih
Fan, Y., Fricker, D., Brager, D. H., Chen, X., Lu, H., Chitwood, R. A., & Johnston, D. (2005) · Nature Neuroscience · doi:10.1038/nn1568 · Cited by 391 · see citing works
Intrinsic Brain Activity in Altered States of Consciousness
Boly, M., Phillips, C. L. M., Tshibanda, L., Vanhaudenhuyse, A., Schabus, M., Dang‐Vu, T. T., Moonen, G., Hustinx, R., Maquet, P., & Laureys, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.015 · Cited by 387 · see citing works
A Brain Mechanism for Facilitation of Insight by Positive Affect
Subramaniam, K., Kounios, J., Parrish, T. B., & Beeman, M. J. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21057 · Cited by 377 · see citing works
Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
Radley, J. J., Rocher, A. B., Rodriguez, A., Ehlenberger, D. B., Dammann, M., McEwen, B. S., Morrison, J. H., Wearne, S. L., & Hof, P. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21588 · Cited by 374 · see citing works
Association and linkage analyses of RGS4 polymorphisms in schizophrenia
Chowdari, K. V. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.12.1373 · Cited by 368 · see citing works
Chapter 19 The determinants of stress-induced activation of the prefrontal cortical dopamine system
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62691-6 · Cited by 364 · see citing works
Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys
Goldman‐Rakic, P. S., & Brown, R. M. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90053-1 · Cited by 357 · see citing works
Arnsten, A. F. T. (1998) · Science · doi:10.1126/science.280.5370.1711 · Cited by 341 · see citing works
Self-citationDuplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia
Vacic, V., McCarthy, S., Malhotra, D., Murray, F., Chou, H.-H., Peoples, A., Makarov, V., Yoon, S., Bhandari, A., Corominas, R., et al. (2011) · Nature · doi:10.1038/nature09884 · Cited by 337 · see citing works
Reduced communication between frontal and temporal lobes during talking in schizophrenia
Ford, J. M., Mathalon, D. H., Whitfield‐Gabrieli, S., Faustman, W. O., & Roth, W. T. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01335-x · Cited by 332 · see citing works
Pathophysiologically based treatment interventions in schizophrenia
Lewis, D. A., & González‐Burgos, G. (2006) · Nature Medicine · doi:10.1038/nm1478 · Cited by 320 · see citing works
Rosenberg, D. R., & Lewis, D. A. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903580306 · Cited by 319 · see citing works
Selective D2 receptor actions on the functional circuitry of working memory
Wang, M., Vijayraghavan, S., & Goldman-Rakic, P. S. (2004) · Science · doi:10.1126/science.1091162 · Cited by 319 · see citing works
Self-citationProtein kinase C overactivity impairs prefrontal cortical regulation of working memory
Birnbaum, S. G., Yuan, P. X., Wang, M., Vijayraghavan, S., Bloom, A. K., Davis, D. J., Gobeske, K. T., Sweatt, J. D., Manji, H. K., & Arnsten, A. F. T. (2004) · Science · doi:10.1126/science.1100021 · Cited by 318 · see citing works
Self-citationBiederman, J., Melmed, R. D., Patel, A., McBurnett, K., Konow, J., Lyne, A., Scherer, N., & for the SPD503 Study Group (2008) · Pediatrics · doi:10.1542/peds.2006-3695 · Cited by 317 · see citing works
Wang, Z., & McCormick, D. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-05-02199.1993 · Cited by 307 · see citing works
Kritzer, M. F., & Goldman‐Rakic, P. S. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590109 · Cited by 300 · see citing works
Divergence of fMRI and neural signals in V1 during perceptual suppression in the awake monkey
Maier, A., Wilke, M., Aura, C. J., Zhu, C., Ye, F. Q., & Leopold, D. A. (2008) · Nature Neuroscience · doi:10.1038/nn.2173 · Cited by 291 · see citing works
Pyramidal Cells of the Frontal Lobe: All the More Spinous to Think With
Elston, G. N. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-j0002.2000 · Cited by 289 · see citing works
Evidence for task-dependent memory dysfunction in the aged monkey
Rapp, P. R., & Amaral, D. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-10-03568.1989 · Cited by 277 · see citing works
Nolan, M. F., Malleret, G., Dudman, J. T., Buhl, D. L., Santoro, B., GIBBS, E., Vronskaya, S., Buzsáki, G., Siegelbaum, S. A., & Kandel, E. R. (2004) · Cell · doi:10.1016/s0092-8674(04)01055-4 · Cited by 274 · see citing works
Synapses are lost during aging in the primate prefrontal cortex
Peters, A., Sethares, C., & Luebke, J. I. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.014 · Cited by 268 · see citing works
The spine neck filters membrane potentials
Araya, R., Jiang, J., Eisenthal, K. B., & Yuste, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608755103 · Cited by 258 · see citing works
Schwartz, M. L., & Goldman, P. S. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902260309 · Cited by 257 · see citing works
Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits
Gao, W.-J., Krimer, L. S., & Goldman-Rakic, P. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.295 · Cited by 257 · see citing works
Beneyto, M., & Meador‐Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301604 · Cited by 255 · see citing works
Pathology of Layer V Pyramidal Neurons in the Prefrontal Cortex of Patients With Schizophrenia
Black, J. E., Kodish, I. M., Grossman, A. W., Klintsova, A. Y., Orlovskaya, D., Vostrikov, V., Uranova, N., & Greenough, W. T. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.742 · Cited by 250 · see citing works
Amat, J., Paul, E., Zarza, C., Watkins, L. R., & Maier, S. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3630-06.2006 · Cited by 249 · see citing works
Huffaker, S. J., Chen, J., Nicodemus, K. K., Sambataro, F., Yang, F., Mattay, V. S., Lipska, B. K., Hyde, T. M., Song, J., Rujescu, D., et al. (2009) · Nature Medicine · doi:10.1038/nm.1962 · Cited by 249 · see citing works
Hains, A. B., Vu, M. A. T., Maciejewski, P. K., van Dyck, C. H., Gottron, M., & Arnsten, A. F. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908563106 · Cited by 234 · see citing works
Self-citationThrough the looking glass: Differential noradenergic modulation of prefrontal cortical function
Arnsten, A. F. T. (2000) · Neural Plasticity · doi:10.1155/np.2000.133 · Cited by 229 · see citing works
Self-citationAge-related changes in multiple neurotransmitter systems in the monkey brain
Wenk, G. L., Pierce, D. J., Struble, R. G., Price, D. L., & Cork, L. C. (1989) · Neurobiology of Aging · doi:10.1016/s0197-4580(89)80005-3 · Cited by 222 · see citing works
Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex
Bloss, E. B., Janssen, W. G., Ohm, D. T., Yuk, F. J., Wadsworth, S., Saardi, K. M., McEwen, B. S., & Morrison, J. H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0839-11.2011 · Cited by 219 · see citing works
Top‐Down Modulation and Normal Aging
Gazzaley, A. H., & D’Esposito, M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.010 · Cited by 219 · see citing works
Dysregulation of Protein Kinase A Signaling in the Aged Prefrontal Cortex
Ramos, B. P., Birnbaum, S. G., Lindenmayer, I., Newton, S. S., Duman, R. S., & Arnsten, A. F. T. (2003) · Neuron · doi:10.1016/s0896-6273(03)00694-9 · Cited by 218 · see citing works
Self-citationFunctional Heteromerization of HCN1 and HCN2 Pacemaker Channels
Ulens, C., & Tytgat, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000738200 · Cited by 217 · see citing works
Rajkowski, J., Majczyński, H., Clayton, E. C., & Aston‐Jones, G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00673.2003 · Cited by 215 · see citing works
Schizophrenia and the α7 Nicotinic Acetylcholine Receptor
Martin, L. F., & Freedman, R. (2007) · International Review of Neurobiology · doi:10.1016/s0074-7742(06)78008-4 · Cited by 213 · see citing works
CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects
Barco, Á., Pittenger, C., & Kandel, E. R. (2003) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.7.1.101 · Cited by 201 · see citing works
Essential Role for the PKC Target MARCKS in Maintaining Dendritic Spine Morphology
Calabrese, B., & Halpain, S. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.027 · Cited by 187 · see citing works
Li, B.-M., & Mei, Z.-T. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80034-2 · Cited by 186 · see citing works
Bussière, T., Giannakopoulos, P., Bouras, C., Perl, D. P., Morrison, J. H., & Hof, P. R. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10760 · Cited by 185 · see citing works
Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia
Arnsten, A. F. T. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.02.006 · Cited by 172 · see citing works
Self-citationDopamine Increases Excitability of Pyramidal Neurons in Primate Prefrontal Cortex
Henze, D. A., González‐Burgos, G., Urban, N. N., Lewis, D. A., & Barrionuevo, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.6.2799 · Cited by 171 · see citing works
The phasic reward signal of primate dopamine neurons
Schultz, W. (1997) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)60841-8 · Cited by 169 · see citing works
Horizontal synaptic connections in monkey prefrontal cortex: An in vitro electrophysiological study
Gonzalez-Burgos, G. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.1.82 · Cited by 169 · see citing works
Specializations of the granular prefrontal cortex of primates: Implications for cognitive processing
Elston, G. N., Benavides‐Piccione, R., Elston, A., Zietsch, B., Defelipe, J., Manger, P., Casagrande, V., & Kaas, J. H. (2006) · The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology · doi:10.1002/ar.a.20278 · Cited by 167 · see citing works
Harrison, P. J., Lyon, L., Sartorius, L. J., Burnet, P., & Lane, T. A. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108089818 · Cited by 166 · see citing works
Cholinergic modulation of a specific memory function of prefrontal cortex
Croxson, P. L., Kyriazis, D. A., & Baxter, M. G. (2011) · Nature Neuroscience · doi:10.1038/nn.2971 · Cited by 166 · see citing works
Li, B. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00070-6 · Cited by 162 · see citing works
Gorelova, N. A., & Yang, C. R. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.75 · Cited by 162 · see citing works
Dynamic network connectivity: a new form of neuroplasticity
Arnsten, A. F. T., Paspalas, C. D., Gamo, N. J., Yang, Y., & Wang, M. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.05.003 · Cited by 160 · see citing works
Self-citationMao, Z.-M., Arnsten, A. F. T., & Li, B.-M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00139-0 · Cited by 156 · see citing works
Self-citationMurdoch, H., Mackie, S., Collins, D. M., Hill, E. V., Bolger, G. B., Klußmann, E., Porteous, D. J., Millar, J. K., & Houslay, M. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1493-07.2007 · Cited by 152 · see citing works
Rotaru, D. C., Yoshino, H., Lewis, D. A., Ermentrout, G. B., & Gonzalez-Burgos, G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1970-10.2011 · Cited by 151 · see citing works
The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys
Ramos, B. P., Colgan, L., Nou, E., Ovadia, S., Wilson, S. R., & Arnsten, A. F. T. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.022 · Cited by 147 · see citing works
Self-citationSun, D., Stuart, G. W., Jenkinson, M., Wood, S. J., McGorry, P. D., Velakoulis, D., van Erp, T. G. M., Thompson, P. M., Toga, A. W., Smith, D. J., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.34 · Cited by 144 · see citing works
Executive system dysfunction occurs as early as middle-age in the rhesus monkey
Moore, T. L., Killiany, R., Herndon, J. G., Rosene, D. L., & Moss, M. B. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.004 · Cited by 143 · see citing works
Behavioral and Neural Changes after Gains and Losses of Conditioned Reinforcers
Seo, H., & Lee, D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4726-08.2009 · Cited by 137 · see citing works
Paspalas, C. D., Wang, M., & Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs152 · Cited by 136 · see citing works
Self-citationLexical priming deficits as a function of age.
Davis, H. P., Cohen, A., Gandy, M., Colombo, P. J., VanDusseldorp, G., Simolke, N., & Romano, J. (1990) · Behavioral Neuroscience · doi:10.1037/0735-7044.104.2.288 · Cited by 134 · see citing works
Broglio, S. P., Eckner, J. T., Paulson, H. L., & Kutcher, J. S. (2012) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182524273 · Cited by 126 · see citing works
Nucleus basalis of Meynert neuronal activity during a delayed response task in monkey
Richardson, R. T., & DeLong, M. R. (1986) · Brain Research · doi:10.1016/0006-8993(86)91529-5 · Cited by 122 · see citing works
Kröner, S., Krimer, L. S., Lewis, D. A., & Barrionuevo, G. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl012 · Cited by 122 · see citing works
Taylor, J. R., Birnbaum, S., Ubriani, R., & Arnsten, A. F. T. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-j0001.1999 · Cited by 120 · cited 1× · see citing works
“For example, increased cAMP signaling enhances long-term consolidation in hippocampal circuits (Abel et al., 1997; Frey et al., 1993; Huang et al., 1994) but markedly weakens PFC working memory (Runyan and Dash, 2005; Taylor et al., 1999).”
Self-citationAbi‐Dargham, A., Xu, X., Thompson, J. L., Gil, R. B., Kegeles, L. S., Urban, N., Narendran, R., Hwang, D., Laruelle, M. A., & Slifstein, M. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111409265 · Cited by 120 · see citing works
Barbas, H., Medalla, M., Alade, O., Suski, J., Zikopoulos, B., & Lera, P. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi018 · Cited by 112 · see citing works
Volk, D. W., Eggan, S. M., & Lewis, D. A. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10030318 · Cited by 111 · see citing works
Hagenston, A. M., Fitzpatrick, J. S., & Yeckel, M. F. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm075 · Cited by 109 · see citing works
Distribution of mGluR1α and mGluR5 immunolabeling in primate prefrontal cortex
Muly, E. C., Maddox, M., & Smith, Y. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10937 · Cited by 108 · see citing works
Mouradian, R. D., Sessler, F. M., & Waterhouse, B. D. (1991) · Brain Research · doi:10.1016/0006-8993(91)91162-t · Cited by 108 · see citing works
Regional alterations in RGS4 protein in schizophrenia
Erdely, H. A., Tamminga, C. A., Roberts, R. C., & Vogel, M. W. (2006) · Synapse · doi:10.1002/syn.20265 · Cited by 99 · see citing works
Castner, S. A., Smagin, G. N., Piser, T. M., Wang, Y., Smith, J. S., Christian, E. P., Mrzljak, L., & Williams, G. V. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.006 · Cited by 90 · see citing works
Kristiansen, L. V., Patel, S. A., Haroutunian, V. H., & Meador‐Woodruff, J. H. (2010) · Synapse · doi:10.1002/syn.20754 · Cited by 86 · see citing works
Faber, E. S. L. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.185645 · Cited by 86 · see citing works
Keedy, S., Ebens, C. L., Keshavan, M. S., & Sweeney, J. A. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.01.003 · Cited by 84 · see citing works
Kobori, N., Clifton, G. L., & Dash, P. K. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.1094 · Cited by 80 · see citing works
The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder
Arnsten, A. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.133 · Cited by 80 · see citing works
Self-citationBuccafusco, J. J., & Terry, A. V. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.102 · Cited by 79 · see citing works
Santini, E., Sepulveda-Orengo, M. T., & Porter, J. T. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.52 · Cited by 79 · see citing works
Moore, T. L., Schettler, S. P., Killiany, R., Herndon, J. G., Luebke, J. I., Moss, M. B., & Rosene, D. L. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.12.003 · Cited by 79 · see citing works
Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque
Downs, J. L., Dunn, M. R., Borók, E., Shanabrough, M., Horváth, T. L., Kohama, S. G., & Urbanski, H. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.025 · Cited by 77 · see citing works
Kremen, W. S., Lachman, M. E., Pruessner, J. C., Sliwinski, M. J., & Wilson, R. S. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls125 · Cited by 77 · see citing works
Prenatal specification of callosal connections in rhesus monkey
Schwartz, M. L., & Goldman‐Rakic, P. S. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903070113 · Cited by 76 · see citing works
Soulsby, M. D., & Wojcikiewicz, R. J. H. (2005) · Biochemical Journal · doi:10.1042/bj20051325 · Cited by 71 · see citing works
McAllister, T. W., McDonald, B. C., Flashman, L. A., Ferrell, R. B., Tosteson, T. D., Yanofsky, N. N., Grove, M. R., & Saykin, A. J. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.06.022 · Cited by 70 · see citing works
Sartorius, L. J., Weinberger, D. R., Hyde, T. M., Harrison, P. J., Kleinman, J. E., & Lipska, B. K. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301669 · Cited by 66 · see citing works
Brennan, A. R., Dolinsky, B., Vu, M.-A. T., Stanley, M., Yeckel, M. F., & Arnsten, A. F. T. (2008) · Learning & Memory · doi:10.1101/lm.767408 · Cited by 63 · see citing works
Self-citationAdrenergic and serotonergic receptors in aged monkey neocortex
Bigham, M. H., & Lidow, M. S. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)80012-g · Cited by 59 · see citing works
Vargas, G., & Lucero, M. T. (2002) · The Journal of Membrane Biology · doi:10.1007/s00232-001-0178-y · Cited by 48 · see citing works
Effects of α-2A adrenergic receptor agonist on time and risk preference in primates
Kim, S., Bobeica, I., Gamo, N. J., Arnsten, A. F. T., & Lee, D. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2520-0 · Cited by 47 · see citing works
Self-citationProtein kinase C activity is associated with prefrontal cortical decline in aging
Brennan, A. R., Yuan, P., Dickstein, D. L., Rocher, A. B., Hof, P. R., Manji, H. K., & Arnsten, A. F. T. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.020 · Cited by 47 · see citing works
Self-citationDifferential expression of cytochrome oxidase (COX) genes in different regions of monkey brain
Chandrasekaran, K., Stoll, J., Giordano, T., Atack, J. R., Matocha, M. F., Brady, D. R., & Рапопорт, С. И. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490320313 · Cited by 44 · see citing works
Raghanti, M. A., Spocter, M. A., Stimpson, C. D., Erwin, J. M., Bonar, C. J., Allman, J. M., Hof, P. R., & Sherwood, C. C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.058 · Cited by 42 · see citing works
Distinct prefrontal molecular mechanisms for information storage lasting seconds versus minutesPreprint
Runyan, J. D., & Dash, P. K. (2005) · Learning & Memory · doi:10.1101/lm.92405 · Cited by 42 · see citing works
Duffy, Á., Zhou, P., Milner, T. A., & Pickel, V. M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.024 · Cited by 40 · see citing works
Receptor-Mediated Suppression of Potassium Currents Requires Colocalization within Lipid Rafts
Oldfield, S., Hancock, J. M., Mason, A., Hobson, S. A., Wynick, D., Kelly, E., Randall, A. D., & Marrion, N. V. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058008 · Cited by 39 · see citing works
Regulation of α2AR trafficking and signaling by interacting proteins
Wang, Q., & Limbird, L. E. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.12.024 · Cited by 39 · see citing works
THOMAS, R. J. (2005) · Sleep Medicine · doi:10.1016/j.sleep.2005.04.005 · Cited by 35 · see citing works
Paspalas, C. D., Selemon, L. D., & Arnsten, A. F. T. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn235 · Cited by 31 · see citing works
Self-citationSawaguchi, T., Matsumura, M., & Kubota, K. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.435 · Cited by 30 · see citing works
McCracken, J. T., Aman, M. G., McDougle, C. J., Tierney, E., Shiraga, S., Whelan, F., Arnold, L. E., Posey, D. J., Ritz, L., Vitiello, B., et al. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2009.0059 · Cited by 28 · see citing works
A-Kinase Anchoring Proteins as the Basis for cAMP Signaling
Dodge‐Kafka, K. L., Bauman, A. L., & Kapiloff, M. S. (2008) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-72843-6_1 · Cited by 25 · see citing works
5.3 Dopamine’s Influence on Prefrontal Cortical Cognition: Actions and Circuits in Behaving Primates
Arnsten, A. F. T., Vijayraghavan, S., Wang, M., Gamo, N. J., & Paspalas, C. D. (2009) · Dopamine Handbook · doi:10.1093/acprof:oso/9780195373035.003.0016 · Cited by 23 · see citing works
Self-citationDeng, X., Takaki, H., Wang, L., Kuroki, T., Nakahara, T., Hashimoto, K., Ninomiya, H., Arinami, T., Inada, T., Ujike, H., et al. (2011) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31233 · Cited by 21 · see citing works
Okada, K., Nakamura, K., & Kobayashi, Y. (2011) · Neural Plasticity · doi:10.1155/2011/579840 · Cited by 20 · see citing works
Arnsten, A. F. T. (2003) · Neuron · doi:10.1016/s0896-6273(03)00685-8 · Cited by 9 · see citing works
Self-citationLidow (1998) · doi:10.1002/(sici)1098-2396(199801)28:1
Flagged first, then by citations
2 of the 168 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
McEwen, B. S., & Morrison, J. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.028 · Cited by 1,079 · see citing works
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.002 · Cited by 938 · see citing works
Orienting and reorienting: the locus coeruleus mediates cognition through arousal
Sara, S. J., & Bouret, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.011 · Cited by 1,056 · see citing works
Dynamic adaptation of large-scale brain networks in response to acute stressors
Hermans, E. J., Henckens, M. J. A. G., Joëls, M., & Fernández, G. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.006 · Cited by 936 · see citing works
Waking state: rapid variations modulate neural and behavioral responses
McGinley, M. J., Vinck, M., Reimer, J., Batista-Brito, R., Zagha, E., Cadwell, C. R., Tolias, A. S., Cardin, J. A., & McCormick, D. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.012 · Cited by 801 · see citing works
“Pharmacological investigations indicate that this relationship depends upon the level of release of neuromodulators, such as dopamine and norepinephrine (Arnsten, 2009; Arnsten et al., 2012).”
Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten, A. F. T. (2015) · Nature Neuroscience · doi:10.1038/nn.4087 · Cited by 752 · see citing works
Self-citationDopamine and Cognitive Control in Prefrontal Cortex
Ott, T., & Nieder, A. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.12.006 · Cited by 530 · see citing works
Wang, M., Yang, Y., Wang, C.-J., Gamo, N. J., Jin, L. E., Mazer, J. A., Morrison, J. H., Wang, X.-J., & Arnsten, A. F. T. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.032 · Cited by 489 · see citing works
Self-citationLogue, S. F., & Gould, T. J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.08.007 · Cited by 477 · see citing works
Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse
Hara, Y., Waters, E. M., McEwen, B. S., & Morrison, J. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00036.2014 · Cited by 470 · see citing works
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control
Speranza, L., di Porzio, U., Viggiano, D., Donato, A. D., & Volpicelli, F. (2021) · Cells · doi:10.3390/cells10040735 · Cited by 430 · see citing works
Human cognitive aging: <i>Corriger la fortune?</i>
Lindenberger, U. (2014) · Science · doi:10.1126/science.1254403 · Cited by 414 · see citing works
Beyond stereotypes of adolescent risk taking: Placing the adolescent brain in developmental context
Römer, D., Reyna, V. F., & Satterthwaite, T. D. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.07.007 · Cited by 421 · see citing works
Arnsten, A. F. T., Raskind, M. A., Taylor, F. B., & Connor, D. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.002 · Cited by 381 · see citing works
Self-citationHassani, S. A., Oemisch, M., Balcarras, M., Westendorff, S., Ardid, S., van der Meer, M. A. A., Tiesinga, P. H. E., & Womelsdorf, T. (2017) · Scientific Reports · doi:10.1038/srep40606 · Cited by 363 · see citing works
Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350 · see citing works
Medial prefrontal cortex in neurological diseases
Xu, P., Chen, A., Li, Y., Xing, X., & Lü, H. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00006.2019 · Cited by 346 · see citing works
Radley, J., Morilak, D., Viau, V., & Campeau, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.018 · Cited by 339 · see citing works
Neuromodulation of brain state and behavior
McCormick, D. A., Nestvogel, D. B., & He, B. J. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100219-105424 · Cited by 303 · see citing works
Cognitive emotion regulation fails the stress test
Raio, C. M., Orederu, T. A., Palazzolo, L., Shurick, A. A., & Phelps, E. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305706110 · Cited by 302 · see citing works
Persistent Spiking Activity Underlies Working Memory
Constantinidis, C., Funahashi, S., Lee, D., Murray, J. D., Qi, X.-L., Wang, M., & Arnsten, A. F. T. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2486-17.2018 · Cited by 274 · see citing works
Self-citationMcKlveen, J. M., Myers, B., & Herman, J. P. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12272 · Cited by 273 · see citing works
Activation of Corticostriatal Circuitry Relieves Chronic Neuropathic Pain
Lee, M., Manders, T. R., Eberle, S. E., Su, C. H., D’amour, J. A., Yang, R., Lin, H. Y., Deisseroth, K. A., Froemke, R. C., & Wang, J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3494-14.2015 · Cited by 257 · see citing works
A Neuroergonomics Approach to Mental Workload, Engagement and Human Performance
Dehais, F., Lafont, A., Roy, R. N., & Fairclough, S. H. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00268 · Cited by 268 · see citing works
Hara, Y., Yuk, F., Puri, R., Janssen, W. G. M., Rapp, P. R., & Morrison, J. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311310110 · Cited by 239 · see citing works
Neuromodulatory Systems and Their Interactions: A Review of Models, Theories, and Experiments
Avery, M. C., & Krichmar, J. L. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00108 · Cited by 231 · see citing works
Developmental origins of brain disorders: roles for dopamine
Money, K. M., & Stanwood, G. D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00260 · Cited by 221 · see citing works
Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?
Ranjbar‐Slamloo, Y., & Fazlali, Z. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00334 · Cited by 222 · see citing works
Benarroch, E. E. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2649-1 · Cited by 218 · see citing works
Ross, J. A., & Bockstaele, E. J. V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.601519 · Cited by 223 · see citing works
Dopaminergic control of cognitive flexibility in humans and animals
Klanker, M., Feenstra, M., & Denys, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00201 · Cited by 209 · see citing works
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex
Shansky, R. M., & Lipps, J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00123 · Cited by 205 · see citing works
“Adapted from Arnsten (2009) and Arnsten et al. (2012).”
BackgroundCools, R., & Arnsten, A. F. T. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01100-8 · Cited by 206 · see citing works
Self-citationMolecular aspects of age-related cognitive decline: the role of GABA signaling
McQuail, J. A., Frazier, C. J., & Bizon, J. L. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.05.002 · Cited by 201 · see citing works
Xing, B., Li, Y.-C., & Gao, W.-J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.005 · Cited by 196 · see citing works
Layer-dependent activity in human prefrontal cortex during working memory
Finn, E. S., Huber, L., Jangraw, D. C., Molfese, P. J., & Bandettini, P. A. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0487-z · Cited by 192 · see citing works
Zagha, E., & McCormick, D. A. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.010 · Cited by 184 · see citing works
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex
Yang, Y., Paspalas, C. D., Jin, L. E., Picciotto, M. R., Arnsten, A. F. T., & Wang, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307849110 · Cited by 188 · see citing works
Self-citationPuig, M. V., Rose, J., Schmidt, R., & Freund, N. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00093 · Cited by 182 · see citing works
Klauss, J., Penido Pinheiro, L. C., Silva Merlo, B. L., Correia Santos, G. D. A., Fregni, F., Nitsche, M. A., & Miyuki Nakamura-Palacios, E. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000984 · Cited by 178 · see citing works
Arion, D., Corradi, J. P., Tang, S., Datta, D., Boothe, F., He, A., Cacace, A. M., Zaczek, R., Albright, C. F., Tseng, G., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.171 · Cited by 177 · see citing works
Prefrontal cortex executive processes affected by stress in health and disease
Girotti, M., Adler, S. M., Bulin, S. E., Fucich, E. A., Paredes, D., & Morilak, D. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.004 · Cited by 176 · see citing works
Maletic, V., Eramo, A., Gwin, K., Offord, S. J., & Duffy, R. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00042 · Cited by 171 · see citing works
Gundersen, V., Storm‐Mathisen, J., & Bergersen, L. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00024.2014 · Cited by 172 · see citing works
Decision Making: From Neuroscience to Psychiatry
Lee, D. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.008 · Cited by 169 · see citing works
Nyberg, L. H., Karalija, N., Salami, A., Andersson, M., Wåhlin, A., Kaboodvand, N., Köhncke, Y., Axelsson, J., Rieckmann, A., Papenberg, G., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606309113 · Cited by 164 · see citing works
Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes.
Woo, E., Sansing, L. H., Arnsten, A. F. T., & Datta, D. (2021) · Chronic Stress · doi:10.1177/24705470211029254 · Cited by 159 · see citing works
Self-citationMenon, B. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109385 · Cited by 154 · see citing works
Dopamine’s Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders
Arnsten, A. F. T., Wang, M., & Paspalas, C. D. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010512 · Cited by 149 · see citing works
Self-citationChemistry of the Adaptive Mind: Lessons from Dopamine
Cools, R. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.035 · Cited by 143 · see citing works
Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?
Atzori, M., Cuevas‐Olguin, R., Esquivel‐Rendon, E., García‐Oscos, F., Salgado‐Delgado, R., Saderi, N., Miranda‐Morales, M., Treviño, M., Pineda, J. C., & Salgado, H. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00025 · Cited by 144 · see citing works
Ventura‐Bort, C., Wirkner, J., Genheimer, H., Wendt, J., Hamm, A. O., & Weymar, M. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00202 · Cited by 141 · see citing works
Increases in Functional Connectivity between Prefrontal Cortex and Striatum during Category Learning
Antzoulatos, E. G., & Miller, E. K. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.005 · Cited by 143 · see citing works
The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder
Adams, T. G., Kelmendi, B., Brake, C. A., Gruner, P., Badour, C. L., & Pittenger, C. (2018) · Chronic Stress · doi:10.1177/2470547018758043 · Cited by 141 · see citing works
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's‐like pathology
Paspalas, C. D., Carlyle, B. C., Leslie, S., Preuss, T. M., Crimins, J. L., Huttner, A. J., van Dyck, C. H., Rosene, D. L., Nairn, A. C., & Arnsten, A. F. T. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.11.005 · Cited by 140 · see citing works
Self-citationcAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
Carlyle, B. C., Nairn, A. C., Wang, M., Yang, Y., Jin, L. E., Simen, A. A., Ramos, B. P., Bordner, K. A., Craft, G. E., Davies, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322360111 · Cited by 139 · see citing works
Self-citationPrefrontal dopamine in associative learning and memory
Puig, M. V., Antzoulatos, E. G., & Miller, E. K. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.026 · Cited by 138 · see citing works
Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex
Wallace, T. L., & Bertrand, D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.04.001 · Cited by 133 · see citing works
The costs and benefits of brain dopamine for cognitive control
Cools, R. (2016) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1401 · Cited by 152 · see citing works
Mechanisms of Working Memory Impairment in Schizophrenia
Van Snellenberg, J. X., Girgis, R. R., Horga, G., van de Giessen, E., Slifstein, M., Ojeil, N., Weinstein, J. J., Moore, H., Lieberman, J. A., Shohamy, D., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.017 · Cited by 123 · see citing works
Ma, Q., Tang, Y., Wang, F., Liao, X., Jiang, X., Wei, S., Mechelli, A., Yong He, A., & Xia, M. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz111 · Cited by 122 · see citing works
Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan, Z., Kim, E., Datta, D., Lewis, D. A., & Soderling, S. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2360-16.2016 · Cited by 120 · see citing works
Santello, M., & Nevian, T. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.003 · Cited by 118 · see citing works
Stress effects on the neural substrates of motivated behavior
Hollon, N. G., Burgeno, L. M., & Phillips, P. E. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4114 · Cited by 118 · see citing works
Su, H., Zhong, N., Gan, H., Wang, J., Han, H., Chen, T., Li, X., Ruan, X., Zhu, Y., Jiang, H., et al. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.01.037 · Cited by 116 · see citing works
Rey, C. D., Lipps, J., & Shansky, R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.338 · Cited by 108 · see citing works
A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex
Froudist‐Walsh, S., Bliss, D. P., Ding, X., Rapan, L., Niu, M., Knoblauch, K., Zilles, K., Kennedy, H., Palomero‐Gallagher, N., & Wang, X. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.024 · Cited by 115 · see citing works
Berridge, C. W., & Spencer, R. C. (2016) · Brain Research · doi:10.1016/j.brainres.2015.11.024 · Cited by 112 · see citing works
Hoftman, G. D., Datta, D., & Lewis, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.022 · Cited by 109 · see citing works
Jin, L. E., Wang, M., Galvin, V. C., Lightbourne, T. C., Conn, P. J., Arnsten, A. F. T., & Paspalas, C. D. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx005 · Cited by 109 · see citing works
Self-citationRole of the Brain's Reward Circuitry in Depression
Nestler, E. J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.07.003 · Cited by 108 · see citing works
Genetic dissection of GABAergic neural circuits in mouse neocortex
Taniguchi, H. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00008 · Cited by 106 · see citing works
Psychostimulants and motivated behavior: Arousal and cognition
Berridge, C. W., & Arnsten, A. F. T. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.005 · Cited by 104 · see citing works
Self-citationTan, T., Wang, W., Liu, T., Zhong, P., Conrow‐Graham, M., Tian, X., & Yan, Z. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108874 · Cited by 103 · see citing works
Connor, D. F., Grasso, D. J., Slivinsky, M. D., Pearson, G. S., & Banga, A. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0119 · Cited by 102 · see citing works
Antisaccade task reflects cortical involvement in mild cognitive impairment
Heuer, H. W., Mirsky, J. B., Kong, E. L., Dickerson, B. C., Miller, B. L., Kramer, J. H., & Boxer, A. L. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a6cbfe · Cited by 102 · see citing works
Catecholamines and cognition after traumatic brain injury
Jenkins, P. O., Mehta, M. A., & Sharp, D. J. (2016) · Brain · doi:10.1093/brain/aww128 · Cited by 102 · see citing works
The Neurobiology of Thought: The Groundbreaking Discoveries of Patricia Goldman-Rakic 1937-2003
Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht195 · Cited by 94 · see citing works
Self-citationThe role of norepinephrine in the pathophysiology of schizophrenia
Mäki-Marttunen, V., Andreassen, O. A., & Espeseth, T. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.038 · Cited by 97 · see citing works
EEG coherence in theta, alpha, and beta bands in frontal regions and executive functions
Basharpoor, S., Heidari, F., & Molavi, P. (2019) · Applied Neuropsychology Adult · doi:10.1080/23279095.2019.1632860 · Cited by 99 · see citing works
Datta, D., Arion, D., Corradi, J., & Lewis, D. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.030 · Cited by 92 · see citing works
Monaco, S. A., Gulchina, Y., & Gao, W. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.022 · Cited by 92 · see citing works
The Lateral Habenula and Adaptive Behaviors
Mizumori, S. J. Y., & Baker, P. M. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.06.001 · Cited by 86 · see citing works
Jha, M. K., Lee, I., & Suk, K. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.006 · Cited by 89 · see citing works
Transcranial Direct Current Stimulation in Substance Use Disorders
Lupi, M., Martinotti, G., Santacroce, R., Cinosi, E., Carlucci, M. C., Marini, S., Acciavatti, T., & Giannantonio, M. D. (2017) · Journal of Ect · doi:10.1097/yct.0000000000000401 · Cited by 88 · see citing works
Vilches, N., Spichiger, C., Mendez, N., Abarzua-Catalan, L., Galdames, H. A., Hazlerigg, D. G., Richter, H. G., & Torres-Farfan, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091313 · Cited by 86 · see citing works
Pyramidal Cell Subtypes and Their Synaptic Connections in Layer 5 of Rat Frontal Cortex
Kawaguchi, Y. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx252 · Cited by 80 · see citing works
An Integrative Model of Effortful Control
André, N., Audiffren, M. F., & Baumeister, R. F. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00079 · Cited by 89 · see citing works
Fuermaier, A. B. M., Tucha, L., Koerts, J., van Heuvelen, M. J. G., van der Zee, E. A., Lange, K. W., & Tucha, O. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090747 · Cited by 82 · see citing works
Neuronal and brain morphological changes in animal models of schizophrenia
Flores, G., Morales‐Medina, J. C., & Díaz, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.034 · Cited by 81 · see citing works
Arnsten, A. F. T., Datta, D., Leslie, S., Yang, S.-T., Wang, M., & Nairn, A. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903671116 · Cited by 74 · see citing works
Self-citationMolecular Influences on Working Memory Circuits in Dorsolateral Prefrontal Cortex
Arnsten, A. F. T., & Jin, L. E. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-420170-5.00008-8 · Cited by 79 · see citing works
Self-citationThe genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex
Arnsten, A. F. T., Datta, D., & Wang, M. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00973-3 · Cited by 76 · see citing works
Self-citationDatta, D., & Arnsten, A. (2019) · Brain Sciences · doi:10.3390/brainsci9050113 · Cited by 78 · see citing works
Self-citationNoradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing
Orlando, I. F., Shine, J. M., Robbins, T. W., Rowe, J. B., & O’Callaghan, C. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105167 · Cited by 77 · see citing works
Forsyth, J. K., Bachman, P., Mathalon, D. H., Roach, B. J., & Asarnow, R. F. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509262112 · Cited by 78 · see citing works
Datta, D., Leslie, S. N., Morozov, Y. M., Duque, A., Rakic, P., van Dyck, C. H., Nairn, A. C., & Arnsten, A. F. T. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1683-1 · Cited by 76 · see citing works
Self-citationSchützler, N., Girwert, C., Hügli, I., Mohana, G., Roignant, J., Ryglewski, S., & Duch, C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813554116 · Cited by 78 · see citing works
The effects of arousal on apical amplification and conscious state
Phillips, W. A., Larkum, M. E., Harley, C. W., & Silverstein, S. M. (2016) · Neuroscience of Consciousness · doi:10.1093/nc/niw015 · Cited by 75 · see citing works
- Authors
- Arnsten, A. F. T., Wang, M. J., & Paspalas, C. D.
- Affiliations
- Yale University (US)
- Corresponding author
- Arnsten, Amy F.T.
- ORCID
- Arnsten, Amy F.T.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 76
- Issue
- 1
- Pages
- 223-239
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3488343
- OpenAlex
- W2087809804
- Cited by
- 538
- References
- 168
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 27 · 2023: 56 · 2022: 30 · 2021: 47 · 2020: 39 · 2019: 28 · 2018: 39 · 2017: 32 · 2016: 41 · 2015: 58 · 2014: 42 · 2013: 38 · 2012: 3
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Yale University
- National Alliance for Research on Schizophrenia and Depression
- Zorginstituut Nederland
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (RL1AA017536)
- National Institute on Aging (P01AG030004)
- National Institute of Mental Health (MH 09335401, R01MH093354)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- neuromodulation, working memory, prefrontal cortex, NMDA receptor, dendritic spines, alpha2A-adrenoceptor, dopamine D1 receptor, recurrent excitation, aging, schizophrenia, fatigue, stress
- MeSH terms
- Animals, Humans, Nerve Net, Synaptic Transmission, Synapses, Thinking, Prefrontal Cortex, Neurotransmitter Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
