CoChat
Sign Up
Cited by 331Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Unmasking Disease-Specific Cerebral Blood Flow Abnormalities: Mood Challenge in Patients With Remitted Unipolar Depression

Liotti, Mario, Mayberg, Helen S., McGinnis, Scott, Brannan, Stephen L., Jerabek, Paul·2002·American Journal of Psychiatry
DOI 10.1176/appi.ajp.159.11.1830
Open this paper in CoChat — free account

Abstract

OBJECTIVE: Remitted major depressive disorder is a vulnerable clinical state, suggesting persistence of an underlying disease diathesis between episodes. To investigate neural correlates of such risk and to identify potential depression trait markers, euthymic unipolar patients in remission, acutely depressed patients, and never-depressed volunteers were studied before and after transient sad mood challenge. METHOD: Common and differential changes in regional blood flow among the groups relative to the baseline state were examined with [(15)O]H(2)O positron emission tomography after provocation of sadness with autobiographical memory scripts. RESULTS: Mood provocation in both depressed groups resulted in regional cerebral blood flow (rCBF) decreases in medial orbitofrontal cortex Brodmann's area 10/11, which were absent in the healthy group. In the remitted group, mood provocation produced a unique rCBF decrease in pregenual anterior cingulate 24a. The main effects in healthy subjects, an rCBF increase in subgenual cingulate Brodmann's area 25 and a decrease in right prefrontal cortex Brodmann's area 9, were not present in the depressed groups. CONCLUSIONS: Mood challenge in unipolar euthymic patients in full remission unmasks an apparent depression trait marker. The pattern of acute CBF changes is distinct from that seen in euthymic healthy volunteers and mirrors the untreated depressed state seen during a major depressive episode and the pattern of change seen in depressed patients. These findings suggest that disease-specific modifications of pathways mediating transient mood changes are present in unipolar depression independent of clinical illness status. These findings have implications for understanding the vulnerability of remitted patients for illness relapse.

Integrity signals

Registry

Crossref · 10.1176/appi.ajp.159.11.1830

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Functional neuroimaging studies in MDD consistently indicate hypoactivation in reward-processing regions, including the dorsal and ventral striatum, medial prefrontal cortex, pregenual and subgenual anterior cingulate, and medial frontal gyrus.

    “Functional neuroimaging studies in MDD have consistently indicated hypoactivation in reward-processing regions, including the dorsal and ventral striatum [210-214] and a host of other reward structures, including the medial prefrontal cortex [215,216], the pregenual and subgenual anterior cingulate, and the medial frontal gyrus [217,218].”

    From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [218]

  • Resting blood flow recordings reveal hypoperfusion across a network of frontoparietal regions and hyperperfusion in subgenual cingulate and anterior insular cortices both in mood disorder and also with induction of transient sadness in healthy subjects.

    “Resting blood flow recordings reveal hypoperfusion across a network of frontoparietal regions and hyperperfusion in subgenual cingulate and anterior insular cortices both in mood disorder and also with induction of transient sadness in healthy subjects (Mayberg et al. 1999; Liotti et al. 2002).”

    From Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression (2008) · cites this paper as Liotti et al. 2002

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Liotti, M., Mayberg, H. S., McGinnis, S., Brannan, S. L., & Jerabek, P.
Affiliations
University of Nottingham (GB)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2002-11-01
Volume
159
Issue
11
Pages
1830-1840
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.159.11.1830
OpenAlex
W2002611894
Cited by
331
References
56
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 6 · 2015: 17 · 2014: 17 · 2013: 13 · 2012: 24
FWCI
11.19
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
major depressive disorder, regional cerebral blood flow, medial orbitofrontal cortex, pregenual anterior cingulate cortex, subgenual anterior cingulate cortex, prefrontal cortex, relapse vulnerability, neural correlates of depression
MeSH terms
Adult, Affect, Antidepressive Agents, Brain, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Middle Aged, Neural Pathways, Oxygen Radioisotopes, Radionuclide Imaging, Recurrence, Reference Values, Regional Blood Flow, Risk

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review