Cited by 177Maternal Mental Health During Pregnancy and PostpartumPregnancy-related medical researchStress Responses and Cortisol

Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study

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Osborne, Lauren M., Gispen, Fiona, Sanyal, Abanti, Yenokyan, Gayane, Meilman, Samantha, Payne, Jennifer L.·2017·Psychoneuroendocrinology

Abstract

Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p=0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.

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Crossref · 10.1016/j.psyneuen.2017.02.012

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  • Dramatic perinatal changes in circulating levels of allopregnanolone are one potential factor affecting GABAergic signaling and postpartum depression development.

    “One potential factor affecting GABAergic signaling and PPD development are dramatic perinatal changes in circulating levels of allopregnanolone, a neuroactive steroid (NAS) GABAA receptor (GABAAR)–positive allosteric modulator (PAM).29,30,31,32”

    From Effect of Zuranolone vs Placebo in Postpartum Depression (2021) · cites this paper as [29]

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Research works printed but not linked: 2

  1. Biggio G Cristina Mostallino M Follesa P Concas A Sanna E 2009 GABA(A) receptor function and gene expression during pregnancy and postpartum Int Rev Neurobiol 85 73 94 19607962
  2. Lindgren M Porcu P Rubinow DR Johnson JL Morrow AL Girdler SS 2012 A history of depression in women is associated with an altered GABAergic neuroactive steroid profile Psychoneuroendocrinology 37 543 553 21890277 PMC3233657

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Authors
Osborne, L. M., Gispen, F., Sanyal, A., Yenokyan, G., Meilman, S., & Payne, J. L.
Affiliations
Johns Hopkins University (US)
Corresponding author
Osborne, Lauren M.
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2017-05
Volume
79
Pages
116-121
ISSN
0306-4530 (ISSN-L)
OpenAlex
W2588649755
Cited by
175
References
55
Citations by year
2026: 14 · 2025: 16 · 2024: 24 · 2023: 17 · 2022: 21 · 2021: 26 · 2020: 20 · 2019: 26 · 2018: 10 · 2017: 1
FWCI
14.64
Type
journal article
Language
en
Open access
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH104262, K23MH074799, R01MH112704)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
allopregnanolone, progesterone, postpartum depression, pregnancy, perinatal mood disorders, progesterone metabolites, second trimester, third trimester, risk prediction
MeSH terms
Adolescent, Adult, Female, Humans, Middle Aged, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, Third, Pregnanolone, Progesterone, Depression, Postpartum, Young Adult

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