Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study
Open accessAbstract
Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p=0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dramatic perinatal changes in circulating levels of allopregnanolone are one potential factor affecting GABAergic signaling and postpartum depression development.
“One potential factor affecting GABAergic signaling and PPD development are dramatic perinatal changes in circulating levels of allopregnanolone, a neuroactive steroid (NAS) GABAA receptor (GABAAR)–positive allosteric modulator (PAM).29,30,31,32”
From Effect of Zuranolone vs Placebo in Postpartum Depression (2021) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701 · see citing works
Multiple Imputation for Nonresponse in Surveys.
Lynn, P. J., & Rubin, D. B. (1988) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348774 · Cited by 2,330 · see citing works
Effects of gonadal steroids in women with a history of postpartum depression
Bloch, M., Schmidt, P. J., Danaceau, M., Murphy, J., Nieman, L., & Rubinow, D. R. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.6.924 · Cited by 950 · see citing works
Yim, I. S., Tanner Stapleton, L. R., Guardino, C. M., Hahn-Holbrook, J., & Dunkel Schetter, C. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-101414-020426 · Cited by 749 · see citing works
Chrousos, G. P., Torpy, D. J., & Gold, P. W. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-3-199808010-00012 · Cited by 707 · see citing works
Uzunova, V., Sheline, Y. I., Davis, J. M., Rasmusson, A. M., Uzunov, D. P., Costa, E., & Guidotti, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3239 · Cited by 672 · see citing works
Maternity blues and major endocrine changes: Cardiff puerperal mood and hormone study II
Harris, B. L., Lovett, L. M., Newcombe, R. G., Read, G. F., Walker, R., & Riad-Fahmy, D. (1994) · BMJ · doi:10.1136/bmj.308.6934.949 · Cited by 487 · see citing works
The role of reproductive hormones in postpartum depression
Schiller, C. E., Meltzer-Brody, S. E., & Rubinow, D. R. (2014) · CNS Spectrums · doi:10.1017/s1092852914000480 · Cited by 480 · see citing works
Effects of Antidepressant Treatment on Neuroactive Steroids in Major Depression
Romeo, E., Ströhle, A., Spalletta, G., di Michele, F., Hermann, B., Holsboer, F., Pasini, A., & Rupprecht, R. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.7.910 · Cited by 463 · see citing works
GABAAR Plasticity during Pregnancy: Relevance to Postpartum Depression
Maguire, J., & Mody, I. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.019 · Cited by 437 · see citing works
Schumacher, M., Mattern, C., Ghoumari, A. M., Oudinet, J., Lière, P., Labombarda, F., Sitruk-Ware, R. L., Nicola, A. F. D., & Guennoun, R. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.09.004 · Cited by 353 · see citing works
The role of allopregnanolone in depression and anxiety
Schüle, C., Nothdurfter, C., & Rupprecht, R. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.09.003 · Cited by 318 · see citing works
New insights into the role of perinatal HPA-axis dysregulation in postpartum depression
Glynn, L. M., Davis, E. P., & Sandman, C. A. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.007 · Cited by 268 · see citing works
Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder.
Girdler, S., Straneva, P. A., Light, K., Pedersen, C., & Morrow, A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01044-1 · Cited by 268 · see citing works
Pinna, G., Costa, E., & Guidotti, A. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0213-2 · Cited by 245 · see citing works
Allopregnanolone and mood disorders
Bäckström, T. C., Bixo, M., Johansson, M., Nyberg, S., Ossewaarde, L., Ragagnin, G., Savić, I., Strömberg, J., Timby, E., van Broekhoven, F., et al. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.07.005 · Cited by 212 · see citing works
Ströhle, A., Romeo, E., Hermann, B., Pasini, A., Spalletta, G., di Michele, F., Holsboer, F., & Rupprecht, R. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00328-x · Cited by 194 · see citing works
Diagnosis, Pathophysiology, and Management of Mood Disorders in Pregnant and Postpartum Women
Yonkers, K. A., Vigod, S. N., & Ross, L. E. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31821187a7 · Cited by 183 · see citing works
HORMONAL ASPECTS OF POSTPARTUM DEPRESSION
Abou‐Saleh, M. T. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00022-5 · Cited by 168 · see citing works
Serum allopregnanolone in women with postpartum “blues”
Nappi, R. (2001) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(00)01112-1 · Cited by 166 · see citing works
Estrogen-related Mood Disorders
Douma, S. L., Husband, C., OʼDonnell, M. E., Barwin, B. N., & Woodend, A. (2005) · Advances in Nursing Science · doi:10.1097/00012272-200510000-00008 · Cited by 164 · see citing works
Padberg, F. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00355-x · Cited by 155 · see citing works
Deligiannidis, K. M., Şıkoğlu, E. M., Shaffer, S. A., Frederick, B. B., Svenson, A., Kopoyan, A., Kosma, C. A., Rothschild, A. J., & Moore, C. M. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.02.010 · Cited by 153 · see citing works
Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study
Epperson, C. N., Gueorguieva, R. V., Czarkowski, K. A., Stiklus, S. M., Sellers, E. M., Krystal, J. H., Rothman, D. L., & Mason, G. F. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0313-7 · Cited by 145 · see citing works
A Reproductive Subtype of Depression
Payne, J. L., Palmer, J. T., & Joffe, H. (2009) · Harvard Review of Psychiatry · doi:10.1080/10673220902899706 · Cited by 144 · see citing works
Self-citationLow Serum Allopregnanolone Is Associated with Symptoms of Depression in Late Pregnancy
Hellgren, C., Åkerud, H., Skalkidou, A., Bäckström, T. C., & Poromaa, I. S. (2014) · Neuropsychobiology · doi:10.1159/000358838 · Cited by 137 · see citing works
Pregnancy-Associated Death: A Qualitative Systematic Review of Homicide and Suicide
Shadigian, E. M., & Bauer, S. (2005) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000155967.72418.6b · Cited by 126 · see citing works
GABA receptors, progesterone and premenstrual dysphoric disorder
Poromaa, I., Smith, S., & Gulinello, M. (2003) · Archives of Women's Mental Health · doi:10.1007/s00737-002-0147-1 · Cited by 123 · see citing works
Ströhle, A., Romeo, E., di Michele, F., Pasini, A., Yassouridis, A., Holsboer, F., & Rupprecht, R. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.1.145 · Cited by 120 · see citing works
3α-reduced neuroactive steroids and their precursors during pregnancy and the postpartum period
Evans, S. E. G., Ross, L. E., Sellers, E. M., Purdy, R. H., & Romach, M. K. (2005) · Gynecological Endocrinology · doi:10.1080/09513590500361747 · Cited by 114 · see citing works
Deligiannidis, K. M., Kroll‐Desrosiers, A., Mo, S., Nguyen, H. P., Svenson, A., Jaitly, N., Hall, J. E., BARTON, B. A., Rothschild, A. J., & Shaffer, S. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.05.010 · Cited by 114 · see citing works
Relevance of endogenous 3α-reduced neurosteroids to depression and antidepressant action
Uzunova, V., Sampson, L., & Uzunov, D. P. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0201-6 · Cited by 108 · see citing works
Allopregnanolone as a mediator of affective switching in reproductive mood disorders
Schiller, C. E., Schmidt, P. J., & Rubinow, D. R. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3599-x · Cited by 107 · see citing works
Harris, B., Lovett, L. M., Smith, J., Read, G., Walker, R., & Newcombe, R. G. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.168.6.739 · Cited by 105 · see citing works
Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels
Osborne, L. M., Clive, M. L., Kimmel, M., Gispen, F. E., Guintivano, J., Brown, T., Cox, O., Judy, J., Meilman, S., Braier, A., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.333 · Cited by 103 · see citing works
Self-citationTransdermal Estradiol for Postpartum Depression: A Promising Treatment Option
Moses‐Kolko, E. L., Berga, S. L., Kalro, B. N., Sit, D. K. Y., & Wisner, K. L. (2009) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3181b5a395 · Cited by 97 · see citing works
Ströhle, A., Pasini, A., Romeo, E., Hermann, B., Spalletta, G., di Michele, F., Holsboer, F., & Rupprecht, R. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00006-6 · Cited by 88 · see citing works
Multifunctional aspects of allopregnanolone in stress and related disorders
Bali, A., & Jaggi, A. S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.005 · Cited by 87 · see citing works
The role of estrogen and progesterone in depression after birth
Klier, C. M., Muzik, M., Dervic, K., Mossaheb, N., Benesch, T., Ulm, B., & Zeller, M. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.09.002 · Cited by 83 · see citing works
Murphy, B. E. P., Steinberg, S. I., Hu, F.-Y., & Allison, C. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8122 · Cited by 74 · see citing works
Heidrich, A., Schleyer, M., Spingler, H., Albert, P. J., Knoche, M., Fritze, J., & Lanczik, M. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90036-1 · Cited by 71 · see citing works
A history of depression in women is associated with an altered GABAergic neuroactive steroid profile
Girdler, S. S., Lindgren, M., Porcu, P., Rubinow, D. R., Johnson, J. L., & Morrow, A. L. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.08.004 · Cited by 66 · see citing works
Response to Flumazenil in Women With Premenstrual Dysphoric Disorder
Mellédo, J. L., Driel, M. V., Coupland, N. J., Lott, P., & Jhangri, G. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.821 · Cited by 64 · see citing works
Crowley, S. K., O’Buckley, T. K., Schiller, C. E., Stuebe, A. M., Morrow, A. L., & Girdler, S. S. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4217-x · Cited by 64 · see citing works
Histories of depression, allopregnanolone responses to stress, and premenstrual symptoms in women
Klatzkin, R. R., Morrow, A. L., Light, K. C., Pedersen, C. A., & Girdler, S. S. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2005.02.007 · Cited by 63 · see citing works
Neuroactive steroids as modulators of depression and anxiety
Eser, D., Romeo, E., Baghai, T. C., di Michele, F., Schüle, C., Pasini, A., Zwanzger, P., Padberg, F., & Rupprecht, R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.007 · Cited by 54 · see citing works
PLASMA AMINE AND HORMONE CHANGES IN ‘POST‐PARTUM BLUEs'
KUEVI, V., Causon, R. C., Dixson, A. F., Everard, D. M., HALL, J. M., Hole, D. R., Whitehead, S. A., WILSON, C. A., & Wise, J. C. M. (1983) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1983.tb00740.x · Cited by 54 · see citing works
‘Maternity blues’ and hormone levels in saliva
FEKSI, A., HARRIS, B., WALKER, R., Riad-Fahmy, D., & Newcombe, R. G. (1984) · Journal of Affective Disorders · doi:10.1016/s0165-0327(84)80013-0 · Cited by 53 · see citing works
Role of progesterone and other neuroactive steroids in anxiety disorders
Melledo, J. L., & Baker, G. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.5.851 · Cited by 46 · see citing works
Kimmel, M., Hess, E., Roy, P. S., Palmer, J. T., Meltzer-Brody, S. E., Meuchel, J. M., Bost-Baxter, E., & Payne, J. L. (2014) · Archives of Women s Mental Health · doi:10.1007/s00737-014-0432-9 · Cited by 38 · see citing works
Self-citationPlasticity and function of extrasynaptic GABAA receptors during pregnancy and after delivery
Mostallino, M. C., Sanna, E., Concas, A., Biggio, G., & Follesa, P. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.013 · Cited by 32 · see citing works
Progesterone and its metabolites as therapeutic targets in psychiatric disorders
Bristot, G., Ascoli, B. M., Gubert, C., Panizzutti, B., Kapczinski, F. P., & Rosa, A. R. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.897329 · Cited by 29 · see citing works
Reproductive hormones and postpartum mood disturbances in Greek women
Chatzicharalampous, C., Rizos, D., Pliatsika, P., Leonardou, A. A., Hassiakos, D., Zervas, I. M., Alexandrou, A., Creatsa, M. G., Konidaris, S., & Lambrinoudaki, I. V. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.501886 · Cited by 28 · see citing works
Diurnal variation in saliva estriol level during pregnancy: A pilot study
McGregor, J., Hastings, C., Roberts, T. J., & Barrett, J. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70705-2 · Cited by 20 · see citing works
Chapter 6 GABAA Receptor Function and Gene Expression During Pregnancy and Postpartum
Biggio, G., Mostallino, M. C., Follesa, P., Concas, A., & Sanna, E. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85006-x · Cited by 18 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Biggio G Cristina Mostallino M Follesa P Concas A Sanna E 2009 GABA(A) receptor function and gene expression during pregnancy and postpartum Int Rev Neurobiol 85 73 94 19607962
- Lindgren M Porcu P Rubinow DR Johnson JL Morrow AL Girdler SS 2012 A history of depression in women is associated with an altered GABAergic neuroactive steroid profile Psychoneuroendocrinology 37 543 553 21890277 PMC3233657
Cited by
Sorted by citations
Meltzer-Brody, S., Colquhoun, H., Riesenberg, R., Epperson, C. N., Deligiannidis, K. M., Rubinow, D. R., Li, H., Sankoh, A. J., Clemson, C., Schacterle, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31551-4 · Cited by 795 · see citing works
Pathophysiological mechanisms implicated in postpartum depression
Payne, J. L., & Maguire, J. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.12.001 · Cited by 459 · see citing works
Self-citationPredictors of Postpartum Depression: A Comprehensive Review of the Last Decade of Evidence
Guintivano, J., Manuck, T. A., & Meltzer-Brody, S. E. (2018) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000368 · Cited by 338 · see citing works
Effect of Zuranolone vs Placebo in Postpartum Depression
Deligiannidis, K. M., Meltzer-Brody, S., Gunduz-Bruce, H., Doherty, J., Jonas, J., Li, S., Sankoh, A. J., Silber, C., Campbell, A. D., Werneburg, B., et al. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.1559 · Cited by 277 · see citing works
Brexanolone for postpartum depression: A meta-analysis of randomized controlled studies
Zheng, W., Cai, D.-B., Zheng, W., Sim, K., Ungvari, G. S., Peng, X.-J., Ning, Y., Wang, G., & Xiang, Y. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.07.006 · Cited by 219 · see citing works
Hantsoo, L., & Epperson, C. N. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100213 · Cited by 199 · see citing works
Poromaa, I. S., Comasco, E., Sumner, R. L., & Eileen Luders, A. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100856 · Cited by 199 · see citing works
Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development
Frieder, A., Fersh, M., Hainline, R., & Deligiannidis, K. M. (2019) · CNS Drugs · doi:10.1007/s40263-019-00605-7 · Cited by 156 · see citing works
Recent advances in understanding/management of premenstrual dysphoric disorder/premenstrual syndrome
Tiranini, L., & Nappi, R. E. (2022) · Faculty Reviews · doi:10.12703/r/11-11 · Cited by 138 · see citing works
Maguire, J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00083 · Cited by 113 · see citing works
Progesterone Actions During Central Nervous System Development
González-Orozco, J. C., & Camacho‐Arroyo, I. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00503 · Cited by 104 · see citing works
Allopregnanolone: An overview on its synthesis and effects
Diviccaro, S., Cioffi, L., Falvo, E., Giatti, S., & Melcangi, R. C. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12996 · Cited by 110 · see citing works
Allopregnanolone-based treatments for postpartum depression: Why/how do they work?
Walton, N., & Maguire, J. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100198 · Cited by 103 · see citing works
Kokras, N., Hodes, G. E., Bangasser, D. A., & Dalla, C. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14710 · Cited by 94 · see citing works
Edinoff, A. N., Odisho, A. S., Lewis, K., Kaskas, A. M., Hunt, G., Cornett, E. M., Kaye, A. D., Kaye, A. M., Morgan, J. H., Barrilleaux, P. S., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.699740 · Cited by 95 · see citing works
Postpartum Depression: Current Status and Possible Identification Using Biomarkers
Yu, Y., Liang, H.-F., Chen, J., Li, Z., Han, Y., Chen, J.-X., & Li, J.-C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.620371 · Cited by 91 · see citing works
Osborne, L. M., Yenokyan, G., Fei, K., Kraus, T., Moran, T. M., Monk, C. E., & SPERLING, R. S. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.08.038 · Cited by 83 · see citing works
Self-citationNovel antidepressant drugs: Beyond monoamine targets
Gonda, X., Döme, P., Neill, J. C., & Tarazi, F. I. (2021) · CNS Spectrums · doi:10.1017/s1092852921000791 · Cited by 81 · see citing works
Towards understanding the biology of premenstrual dysphoric disorder: From genes to GABA
Hantsoo, L. V., & Payne, J. L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105168 · Cited by 72 · see citing works
Self-citationNeural correlates of depression in women across the reproductive lifespan – An fMRI review
Stickel, S., Wagels, L., Wudarczyk, O. A., Jaffee, S. R., Habel, U., Schneider, F. W., & Chechko, N. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.12.133 · Cited by 70 · see citing works
Allopregnanolone in mood disorders: Mechanism and therapeutic development
Chen, S., Gao, L., Li, X., & Ye, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105682 · Cited by 69 · see citing works
Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor
Belelli, D., Hogenkamp, D., Gee, K. W., & Lambert, J. J. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100207 · Cited by 67 · see citing works
The Menstrual Cycle Influences Emotion but Has Limited Effect on Cognitive Function.
Sundström-Poromaa, I. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.01.016 · Cited by 62 · see citing works
Animal models of post-traumatic stress disorder and novel treatment targets
Aspesi, D., & Pinna, G. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000467 · Cited by 65 · see citing works
Balan, I. S., Patterson, R., Boero, G., Krohn, H., O’Buckley, T. K., Meltzer-Brody, S. E., & Morrow, A. L. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104473 · Cited by 64 · see citing works
Karim, N., Khan, I., Abdelhalim, A., Halim, S. A., Khan, A., & Al-Harrasi, A. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153646 · Cited by 63 · see citing works
A Comprehensive Review on Postpartum Depression
Suryawanshi, O., & Pajai, S. (2022) · Cureus · doi:10.7759/cureus.32745 · Cited by 63 · see citing works
Pregnancy, postpartum and parity: Resilience and vulnerability in brain health and disease
Deems, N. P., & Leuner, B. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100820 · Cited by 63 · see citing works
Almeida, F. B., Barros, H. M. T., & Pinna, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041758 · Cited by 57 · see citing works
Córdoba, S. M., Pickering, S., Ortega, M. A., Asúnsolo, Á., & Romero, D. R. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17249328 · Cited by 55 · see citing works
Hellgren, C., Comasco, E., Skalkidou, A., & Poromaa, I. S. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.06.008 · Cited by 55 · see citing works
Tau Phosphorylation in Female Neurodegeneration: Role of Estrogens, Progesterone, and Prolactin
Muñoz-Mayorga, D., Guerra‐Araiza, C., Torner, L., & Morales, T. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00133 · Cited by 55 · see citing works
Allopregnanolone and reproductive psychiatry: an overview
McEvoy, K., & Osborne, L. M. (2019) · International Review of Psychiatry · doi:10.1080/09540261.2018.1553775 · Cited by 51 · see citing works
Self-citationLeveraging research into sex differences and steroid hormones to improve brain health
Lee, B. H., Eid, R. S., Hodges, T. E., Barth, C., & Galea, L. A. M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01061-0 · Cited by 48 · see citing works
The Role of Allopregnanolone in Pregnancy in Predicting Postpartum Anxiety Symptoms
Osborne, L. M., Betz, J., Yenokyan, G., Standeven, L. R., & Payne, J. L. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01033 · Cited by 46 · see citing works
Self-citationMulti-omics and machine learning for the prevention and management of female reproductive health
Kharb, S., & Joshi, A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1081667 · Cited by 47 · see citing works
Progesterone and Its Metabolites Play a Beneficial Role in Affect Regulation in the Female Brain
Stefaniak, M., Dmoch–Gajzlerska, E., Jankowska, K. K., Rogowski, A., Kajdy, A., & Maksym, R. (2023) · Pharmaceuticals · doi:10.3390/ph16040520 · Cited by 45 · see citing works
T-cell defects and postpartum depression
Osborne, L. M., Gilden, J., Kamperman, A. M., Hoogendijk, W. J. G., Spicer, J., Drexhage, H. A., & Bergink, V. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.01.007 · Cited by 45 · see citing works
Self-citationProgesterone, reproduction, and psychiatric illness
Standeven, L. R., McEvoy, K., & Osborne, L. M. (2020) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2020.06.001 · Cited by 52 · see citing works
Self-citationMoog, N. K., Heim, C. C., Entringer, S., Simhan, H. N., Wadhwa, P. D., & Buß, C. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173372 · Cited by 43 · see citing works
Allopregnanolone in Postpartum Depression
Pinna, G., Almeida, F. B., & Davis, J. M. (2022) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2022.823616 · Cited by 42 · see citing works
Fitzgerald, E., Parent, C. I., Kee, M. Z. L., & Meaney, M. J. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.635304 · Cited by 39 · see citing works
Management of perinatal depression with non-drug interventions
Johansen, S. L., Robakis, T. K., Williams, K. E., & Rasgon, N. (2019) · BMJ · doi:10.1136/bmj.l322 · Cited by 40 · see citing works
The plasma metabolome of women in early pregnancy differs from that of non-pregnant women
Handelman, S. K., Romero, R. J., Tarca, A. L., Pacora, P., Ingram, B. O., Maymon, E., Chaiworapongsa, T., Hassan, S. S., & Erez, O. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224682 · Cited by 38 · see citing works
Reddy, D. S., Mbilinyi, R. H., & Estes, E. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06427-2 · Cited by 37 · see citing works
Perinatal depression: Heterogeneity of disease and in animal models
Qiu, W., Hodges, T. E., Clark, E. L., Blankers, S. A., & Galea, L. A. M. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100854 · Cited by 37 · see citing works
Neuroactive steroids and depression in early pregnancy
Wenzel, E., Pinna, G., Eisenlohr-Moul, T. A., Bernabé, B. P., Romay-Tallón, R., Nagelli, U., Davis, J. M., & Maki, P. M. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105424 · Cited by 37 · see citing works
Gut microbiota: Linking nutrition and perinatal depression
Song, J. G., Bi, Z., Kan, J., Liu, G., Zhang, S., Si, L., Zhang, X., Yang, X., Ma, J., Cheng, J., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.932309 · Cited by 37 · see citing works
Exposure to environmental chemicals and perinatal psychopathology
Jacobson, M. H., Ghassabian, A., Gore, A. C., & Trasande, L. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114835 · Cited by 36 · see citing works
Zuranolone – synthetic neurosteroid in treatment of mental disorders: narrative review
Marecki, R., Kałuska, J., Kolanek, A., Hakało, D., & Waszkiewicz, N. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1298359 · Cited by 35 · see citing works
Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature
McEvoy, K., Payne, J. L., & Osborne, L. M. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0937-4 · Cited by 35 · see citing works
Self-citationRisk of Depression Associated With Finasteride Treatment
Pompili, M., Magistri, C., Maddalena, S., Mellini, C., Persechino, S., & Baldessarini, R. J. (2021) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001379 · Cited by 34 · see citing works
Bränn, E., Malavaki, C. J., Fransson, E., Ioannidi, M.-K., Henriksson, H. E., Papadopoulos, F. C., Chrousos, G. P., Klapa, M. I., & Skalkidou, A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.685656 · Cited by 32 · see citing works
Chechko, N., Losse, E. M., Frodl, T., & Nehls, S. (2023) · BJPsych Open · doi:10.1192/bjo.2023.612 · Cited by 32 · see citing works
Jacobson, M. H., Stein, C. R., Liu, M., Ackerman, M. G., Blakemore, J. K., Long, S. E., Pinna, G., Romay-Tallón, R., Kannan, K., Zhu, H., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab199 · Cited by 33 · see citing works
Relating neurosteroid modulation of inhibitory neurotransmission to behaviour
Belelli, D., Phillips, G., Atack, J. R., & Lambert, J. J. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13045 · Cited by 32 · see citing works
Deligiannidis, K. M., Kroll-Desrosiers, A. R., Tan, Y., Dubuke, M. L., & Shaffer, S. A. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104827 · Cited by 31 · see citing works
The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes
Sawyer, K. M. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100390 · Cited by 32 · see citing works
Giatti, S., Diviccaro, S., Falvo, E., García‐Segura, L. M., & Melcangi, R. C. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100836 · Cited by 32 · see citing works
Faden, J., & Citrome, L. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320968658 · Cited by 30 · see citing works
Xie, H., Xie, Z., Luan, F., Zeng, J., Zhang, X., Chen, L., Zeng, N., & Liu, R. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117785 · Cited by 27 · see citing works
Neurobiology of maternal mental illness
Maguire, J., McCormack, C., Mitchell, A., & Monk, C. E. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64239-4.00005-9 · Cited by 27 · see citing works
Walther, A., Tsao, C., Pande, R., Kirschbaum, C., Field, E., & Berkman, L. F. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104382 · Cited by 27 · see citing works
Creeth, H., & John, R. M. (2020) · Placenta · doi:10.1016/j.placenta.2020.03.011 · Cited by 26 · see citing works
Bottemanne, H., Vahdat, B., Jouault, C., Tibi, R., & Joly, L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.764207 · Cited by 26 · see citing works
Chen, M., Chou, C., Hsiao, T., Wu, T.-Y., Li, C., Chen, Y., Chao, K., Lee, T., Gicana, R. G., Shih, C.-J., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2424911 · Cited by 24 · see citing works
Ren, P., Ma, L., Wang, J.-Y., Guo, H., Sun, L. J., Gao, M., Liu, Y., Ma, Y., Li, Y., & Guo, W.-Z. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03036-9 · Cited by 23 · see citing works
Brexanolone for the treatment of patients with postpartum depression
Morrison, K. E., Cole, A. B., Thompson, S. M., & Bale, T. L. (2019) · Drugs of today · doi:10.1358/dot.2019.55.9.3040864 · Cited by 22 · see citing works
Allopregnanolone and depression and anxiety symptoms across the peripartum: an exploratory study
Standeven, L. R., Osborne, L. M., Betz, J., Yenokyan, G., Voegtline, K., Hantsoo, L. V., & Payne, J. L. (2021) · Archives of Women s Mental Health · doi:10.1007/s00737-021-01186-5 · Cited by 21 · see citing works
Self-citationEffects of fast-acting antidepressant drugs on a postpartum depression mice model
García-Baos, A., Gallego‐Landin, I., Ferreres-Álvarez, I., Puig-Reyné, X., Castro‐Zavala, A., Valverde, O., & Martín‐Sánchez, A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113598 · Cited by 19 · see citing works
Gao, Q., Sun, W., Wang, Y.-R., Li, Z., Zhao, F., Geng, X., Xu, K., Chen, D., Liu, K., Xing, Y., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1140796 · Cited by 23 · see citing works
Redei, E. E., Ciolino, J. D., Wert, S. L., Yang, A., Kim, S., Clark, C. T., Zumpf, K. B., & Wisner, K. L. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01188-4 · Cited by 20 · see citing works
Gündoğmuş, A. G., Katar, K. S., Örsel, S., Öztürk, G., & Yılmaz, K. B. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277119 · Cited by 19 · see citing works
Carlini, S. V., Osborne, L. M., & Deligiannidis, K. M. (2023) · Dialogues in Clinical Neuroscience · doi:10.1080/19585969.2023.2262464 · Cited by 20 · see citing works
Self-citationBurke, C. S., Susser, L. C., & Hermann, A. D. (2018) · Archives of Women s Mental Health · doi:10.1007/s00737-018-0871-9 · Cited by 19 · see citing works
Evolutionary and genetic insights for clinical psychology
Crespi, B. J. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101857 · Cited by 18 · see citing works
The neurobiology of postpartum depression
Wenzel, E., Frye, R., Roberson‐Nay, R., & Payne, J. L. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.05.005 · Cited by 18 · see citing works
Self-citationNeurosteroids: A potential target for neuropsychiatric disorders
Wang, M., Hu, S.-W., Fu, X., Zhou, H., Yang, S., & Yang, C. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106485 · Cited by 18 · see citing works
Balta, G., Dalla, C., & Kokras, N. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9721-0_11 · Cited by 18 · see citing works
Metabolites of progesterone in pregnancy: Associations with perinatal anxiety
Etyemez, S., Miller, K. N., Voegtline, K., Özdemir, İ., Standeven, L. R., Santovito, L. S., Pinna, G., Payne, J. L., & Osborne, L. M. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106327 · Cited by 17 · see citing works
Self-citationMaddahi, A., Warfvinge, K., Holm, A., Edvinsson, J. C. A., Reducha, P. V., Kazantzi, S., Haanes, K. A., & Edvinsson, L. I. (2023) · The Journal of Headache and Pain · doi:10.1186/s10194-023-01687-x · Cited by 17 · see citing works
Drexhage, H. A., Bergink, V., Poletti, S., Benedetti, F., & Osborne, L. M. (2024) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2024.2420053 · Cited by 16 · see citing works
Self-citationProgestogen profiling in plasma during the estrous cycle in cattle using an LC-MS based approach
Hankele, A., Rehm, K., Bérard, J., Schuler, G. C., Bigler, L., & Ulbrich, S. E. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.10.005 · Cited by 16 · see citing works
Dabbah‐Assadi, F., Handel, R., & Shamir, A. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.09.032 · Cited by 14 · see citing works
Kazemi, A., Ghaedrahmati, M., Kheirabadi, G., Bahrami, M., & Ebrahimi, A. (2018) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_6_18 · Cited by 14 · see citing works
A multilevel developmental psychopathology model of childbirth and the perinatal transition
Kaliush, P. R., Conradt, E. D., Kerig, P. K., Williams, P., & Crowell, S. E. (2023) · Development and Psychopathology · doi:10.1017/s0954579422001389 · Cited by 13 · see citing works
Progesterone modulates theta oscillations in the frontal‐parietal network
Riddle, J., Ahn, S., McPherson, T., Girdler, S. S., & Frӧhlich, F. (2020) · Psychophysiology · doi:10.1111/psyp.13632 · Cited by 13 · see citing works
Vacher, C., Tsompanidis, A., Firestein, M. R., & Penn, A. A. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.13489 · Cited by 12 · see citing works
Welander, N. Z., Mwinyi, J., Asif, S., Schiöth, H. B., Skalkidou, A., & Fransson, E. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.08.119 · Cited by 12 · see citing works
Pinna, G. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13226 · Cited by 12 · see citing works
Postpartum depression and mother–offspring conflict over maternal investment
Gunst, A., Sundén, M., Korja, R., Boddy, A. M., Kotler, J., Paavonen, E. J., Uusitupa, H., Karlsson, L., Karlsson, H., & Antfolk, J. (2020) · Evolution Medicine and Public Health · doi:10.1093/emph/eoaa049 · Cited by 12 · see citing works
Osborne, L. M., Etyemez, S., Pinna, G., Alemani, R., Standeven, L. R., Wang, X., & Payne, J. L. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02052-z · Cited by 11 · see citing works
Self-citationNeurosteroids and early-life programming: An updated perspective
Sze, Y., & Brunton, P. J. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100367 · Cited by 11 · see citing works
Ganguly, M., Ganguly, A., Chattaraj, S., & Midya, D. K. (2025) · Discover Public Health · doi:10.1186/s12982-025-00485-x · Cited by 14 · see citing works
Approche GABAergique de la dépression du post-partum : une revue critique translationnelle
Verbe, J., Dubertret, C., El‐Hage, W., Bonnet‐Brilhault, F., & Duriez, P. (2019) · L Encéphale · doi:10.1016/j.encep.2019.09.007 · Cited by 10 · see citing works
Mayne, G., Bloois, E. D., Dabelea, D., & Christians, U. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03523-0 · Cited by 10 · see citing works
Horwitz, A. B., & Rubín, R. T. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1139889 · Cited by 10 · see citing works
Fayoud, A. M., Orebi, H. A., Elshnoudy, I. A., Elsebaie, M. A. T., Elewidi, M. M. M., & Sabra, H. K. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06611-y · Cited by 9 · see citing works
Biomarkers of reproductive psychiatric disorders
Etyemez, S., Mehta, K., Iyer, S., Özdemir, İ., & Osborne, L. M. (2025) · The British Journal of Psychiatry · doi:10.1192/bjp.2025.134 · Cited by 8 · see citing works
Self-citationMid-pregnancy allopregnanolone levels and trajectories of perinatal depressive symptoms
Björvang, R. D., Walldén, Y., Fransson, E., Comasco, E., Poromaa, I. S., & Skalkidou, A. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107009 · Cited by 8 · see citing works
- Authors
- Osborne, L. M., Gispen, F., Sanyal, A., Yenokyan, G., Meilman, S., & Payne, J. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Osborne, Lauren M.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 79
- Pages
- 116-121
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC5420429
- OpenAlex
- W2588649755
- Cited by
- 175
- References
- 55
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 24 · 2023: 17 · 2022: 21 · 2021: 26 · 2020: 20 · 2019: 26 · 2018: 10 · 2017: 1
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH104262, K23MH074799, R01MH112704)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- allopregnanolone, progesterone, postpartum depression, pregnancy, perinatal mood disorders, progesterone metabolites, second trimester, third trimester, risk prediction
- MeSH terms
- Adolescent, Adult, Female, Humans, Middle Aged, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, Third, Pregnanolone, Progesterone, Depression, Postpartum, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review