Serum allopregnanolone in women with postpartum “blues”
Abstract
Objective To relate serum allopregnanolone and progesterone levels postpartum to maternity "blues." Methods Forty primiparous, healthy, married women (24-39 years of age; at least 13 years of education) who delivered healthy neonates in the Department of Obstetrics at the University of Pavia entered the present study. Blood samples were drawn at 8:30 AM on postpartum day 3 for measurements of serum allopregnanolone, progesterone, cortisol, prolactin, and estradiol. On the same day, every woman was interviewed using the Hamilton Rating Scale for Depression for psychometric testing and completed a self-administered version of the Stein Questionnaire for symptoms of the "blues." Results Eighteen of 40 women (45%) experienced maternity "blues" (12 who delivered vaginally and six who delivered by cesarean). Serum allopregnanolone levels were significantly lower in those women experiencing postpartum "blues" with respect to euthymic women (1.1 +/- 0.4 versus 2.3 +/- 1.0 nmol/L; P .058). Allopregnanolone and progesterone levels correlated significantly in euthymic women (r =.648; P =.001) but not in those with postpartum "blues" (r =.317; P =.199). There was a significant negative correlation between the Hamilton score and levels of serum allopregnanolone (r = -.62; P =.001) and progesterone (r = -.36; P =.024). Conclusion Serum allopregnanolone levels were detectable postpartum and were significantly decreased in women with maternity "blues."
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Dramatic perinatal changes in circulating levels of allopregnanolone are one potential factor affecting GABAergic signaling and postpartum depression development.
“One potential factor affecting GABAergic signaling and PPD development are dramatic perinatal changes in circulating levels of allopregnanolone, a neuroactive steroid (NAS) GABAA receptor (GABAAR)–positive allosteric modulator (PAM).29,30,31,32”
From Effect of Zuranolone vs Placebo in Postpartum Depression (2021) · cites this paper as [31]
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- Authors
- Nappi, R.
- Affiliations
- University of Siena (IT)
- ORCID
- Nappi, R
- Venue
- Obstetrics & Gynecology
- Published
- 2001-01
- Volume
- 97
- Issue
- 1
- Pages
- 77-80
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2004123621
- Cited by
- 166
- References
- 28
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 13 · 2020: 5 · 2019: 14 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 11 · 2014: 3 · 2013: 12 · 2012: 4
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- allopregnanolone, postpartum blues, postpartum depression, progesterone, serum steroid hormones, primiparous women, cortisol, prolactin, estradiol, Hamilton Depression Rating Scale
- MeSH terms
- Adult, Female, Humans, Pregnanolone, Progesterone, Prospective Studies, Biomarkers, Depression, Postpartum
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