Cited by 59

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Helminthic therapy: improving mucosal barrier function

Wolff, Martin J., Broadhurst, Mara J., Loke, P’ng·2012·Trends in Parasitology

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.pt.2012.02.008

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 4 references

Research works printed but not linked: 81

  1. Maizels, 2003, Immune regulation by helminth parasites: cellular and molecular mechanisms, Nat. Rev. Immunol., 3, 733, 10.1038/nri1183 · DOI
  2. Artis, 2008, The intestinal epithelium: sensors to effectors in nematode infection, Mucosal Immunol., 1, 252, 10.1038/mi.2008.21 · DOI
  3. Summers, 2003, Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease, Am. J. Gastroenterol., 98, 2034, 10.1111/j.1572-0241.2003.07660.x · DOI
  4. Summers, 2005, Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial, Gastroenterology, 128, 825, 10.1053/j.gastro.2005.01.005 · DOI · Paper page
  5. Summers, 2005, Why Trichuris suis should prove safe for use in inflammatory bowel diseases, Inflamm. Bowel Dis., 11, 783, 10.1097/01.MIB.0000179316.50002.f3 · DOI
  6. Summers, 2006, Therapeutic colonization with Trichuris suis, Arch. Pathol. Lab. Med., 130, 1753, 10.5858/2006-130-1753a-TCWTS · DOI
  7. Summers, 2005, Trichuris suis therapy in Crohn's disease, Gut, 54, 87, 10.1136/gut.2004.041749 · DOI · Paper page
  8. Walmsley, 1998, A simple clinical colitis activity index, Gut, 43, 29, 10.1136/gut.43.1.29 · DOI
  9. Bager, 2010, Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial, J. Allergy Clin. Immunol., 125, 10.1016/j.jaci.2009.08.006 · DOI
  10. Fleming, 2006, Multiple sclerosis and the hygiene hypothesis, Neurology, 67, 2085, 10.1212/01.wnl.0000247663.40297.2d · DOI
  11. Correale, 2007, Association between parasite infection and immune responses in multiple sclerosis, Ann. Neurol., 61, 97, 10.1002/ana.21067 · DOI
  12. Correale, 2008, Helminth infections associated with multiple sclerosis induce regulatory B cells, Ann. Neurol., 64, 187, 10.1002/ana.21438 · DOI
  13. Correale, 2011, The impact of parasite infections on the course of multiple sclerosis, J. Neuroimmunol., 233, 6, 10.1016/j.jneuroim.2011.01.002 · DOI · Paper page
  14. Fleming, 2011, Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study, Mult. Scler. J., 17, 743, 10.1177/1352458511398054 · DOI
  15. Reddy, 2007, The use of Trichuris suis and other helminth therapies to treat Crohn's disease, Parasitol. Res., 100, 921, 10.1007/s00436-006-0416-4 · DOI
  16. Kradin, 2006, Iatrogenic Trichuris suis infection in a patient with Crohn disease, Arch. Pathol. Lab. Med., 130, 718, 10.5858/2006-130-718-ITSIIA · DOI
  17. Hsu, 2005, Trichuris suis therapy for ulcerative colitis: nonresponsive patients may need anti-helminth therapy, Gastroenterology, 129, 768
  18. Van Kruiningen, 2005, Potential danger in the medical use of Trichuris suis for the treatment of inflammatory bowel disease, Inflamm. Bowel Dis., 11, 515, 10.1097/01.MIB.0000160369.47671.a2 · DOI
  19. Shin, 2004, Does whipworm increase the pathogenicity of Campylobacter jejuni?. A clinical correlate of an experimental observation, Can. J. Gastroenterol., 18, 175, 10.1155/2004/298064 · DOI
  20. Bager, 2011, Symptoms after ingestion of pig whipworm Trichuris suis eggs in a randomized placebo-controlled double-blind clinical trial, PLoS ONE, 6, e22346, 10.1371/journal.pone.0022346 · DOI
  21. Mansfield, 2003, Enhancement of disease and pathology by synergy of Trichuris suis and Campylobacter jejuni in the colon of immunologically naive swine, Am. J. Trop. Med. Hyg., 68, 70, 10.4269/ajtmh.2003.68.70 · DOI
  22. Abner, 2002, Response of intestinal epithelial cells to Trichuris suis excretory–secretory products and the influence on Campylobacter jejuni invasion under in vitro conditions, J. Parasitol., 88, 738
  23. de Silva, 2003, Soil-transmitted helminth infections: updating the global picture, Trends Parasitol., 19, 547, 10.1016/j.pt.2003.10.002 · DOI
  24. Mortimer, 2006, Dose-ranging study for trials of therapeutic infection with Necator Americanus in humans, Am. J. Trop. Med. Hyg., 75, 914, 10.4269/ajtmh.2006.75.914 · DOI
  25. Loukas, 2001, Immune responses in hookworm infections, Clin. Microbiol. Rev., 14, 689, 10.1128/CMR.14.4.689-703.2001 · DOI
  26. Wilson, 2004, Regulation of allergy and autoimmunity in helminth infection, Clin. Rev. Allergy Immunol., 26, 35, 10.1385/CRIAI:26:1:35 · DOI
  27. Yazdanbakhsh, 2002, Allergy, parasites and the hygiene hypothesis, Science, 296, 490, 10.1126/science.296.5567.490 · DOI
  28. Scrivener, 2001, Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study, Lancet, 358, 1493, 10.1016/S0140-6736(01)06579-5 · DOI
  29. Feary, 2010, Experimental hookworm infection: a randomized placebo-controlled trial in asthma, Clin. Exp. Allergy, 40, 299, 10.1111/j.1365-2222.2009.03433.x · DOI · Paper page
  30. Daveson, 2011, Effect of hookworm infection on wheat challenge in celiac disease – a randomised double-blinded placebo controlled trial, PLoS ONE, 6, e17366, 10.1371/journal.pone.0017366 · DOI · Paper page
  31. Croese, 2006, A proof of concept study establishing Necator Americanus in Crohn's patients and reservoir donors, Gut, 55, 136, 10.1136/gut.2005.079129 · DOI · Paper page
  32. Gaze, 2012, Characterising the mucosal and systemic immune responses to experimental human hookworm infection, PLOS Pathog., 8, e1002520, 10.1371/journal.ppat.1002520 · DOI
  33. McSorley, 2011, Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection, PLoS ONE, 6, e24092, 10.1371/journal.pone.0024092 · DOI
  34. Elliott, 2012, Helminth–host immunological interactions: prevention and control of immune-mediated diseases, Ann. N. Y. Acad. Sci., 1247, 83, 10.1111/j.1749-6632.2011.06292.x · DOI
  35. Fallon, 2007, Suppression of TH2-type allergic reactions by helminth infection, Nat. Rev. Immunol., 7, 220, 10.1038/nri2039 · DOI
  36. Blankenhaus, 2011, Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice, J. Immunol., 186, 4295, 10.4049/jimmunol.1001920 · DOI
  37. Rausch, 2009, Establishment of nematode infection despite increased TH2 responses and immunopathology after selective depletion of Foxp3+ cells, Eur. J. Immunol., 39, 3066, 10.1002/eji.200939644 · DOI
  38. Wilson, 2005, Suppression of allergic airway inflammation by helminth-induced regulatory T cells, J. Exp. Med., 202, 1199, 10.1084/jem.20042572 · DOI
  39. Pacífico, 2009, Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10, Infect. Immun., 77, 98, 10.1128/IAI.00783-07 · DOI
  40. Dittrich, 2008, Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation and hyperreactivity in a murine asthma model, J. Immunol., 180, 1792, 10.4049/jimmunol.180.3.1792 · DOI
  41. Liu, 2009, Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms, Infect. Immun., 77, 5347, 10.1128/IAI.01170-08 · DOI
  42. Zaccone, 2009, Schistosoma mansoni egg antigens induce Treg that participate in diabetes prevention in NOD mice, Eur. J. Immunol., 39, 1098, 10.1002/eji.200838871 · DOI
  43. Hubner, 2012, Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-β, J. Immunol., 188, 559, 10.4049/jimmunol.1100335 · DOI
  44. Walsh, 2009, Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of TH17 and TH1 responses, J. Immunol., 183, 1577, 10.4049/jimmunol.0803803 · DOI
  45. Smith, 2007, Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism, J. Immunol., 178, 4557, 10.4049/jimmunol.178.7.4557 · DOI
  46. Johnston, 2010, Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice, Infect. Immun., 78, 1364, 10.1128/IAI.01349-08 · DOI
  47. Hang, 2010, Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity, J. Immunol., 185, 3184, 10.4049/jimmunol.1000941 · DOI
  48. Bar On, 2011, Management of gut inflammation through the manipulation of intestinal dendritic cells and macrophages?, Semin. Immunol., 23, 58, 10.1016/j.smim.2011.01.002 · DOI
  49. Allen, 2011, Evolution of TH2 immunity: a rapid repair response to tissue destructive pathogens, PLOS Pathog., 7, e1002003, 10.1371/journal.ppat.1002003 · DOI
  50. Hunter, 2010, In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice, Gastroenterology, 138, 1395, 10.1053/j.gastro.2009.12.041 · DOI
  51. Broadhurst, 2010, IL-22+ CD4+ T cells are associated with therapeutic Trichuris trichiura infection in an ulcerative colitis patient, Sci. Transl. Med., 2, 60ra88, 10.1126/scitranslmed.3001500 · DOI
  52. Sonnenberg, 2011, Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22, Nat. Immunol., 12, 383, 10.1038/ni.2025 · DOI
  53. Finkelman, 2004, Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites, Immunol. Rev., 201, 139, 10.1111/j.0105-2896.2004.00192.x · DOI · Paper page
  54. Seno, 2009, Efficient colonic mucosal wound repair requires Trem2 signaling, Proc. Natl. Acad. Sci. U.S.A., 106, 256, 10.1073/pnas.0803343106 · DOI
  55. Sugimoto, 2008, IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis, J. Clin. Investig., 118, 534
  56. Zenewicz, 2008, Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease, Immunity, 29, 947, 10.1016/j.immuni.2008.11.003 · DOI
  57. Johansson, 2011, Composition and functional role of the mucus layers in the intestine, Cell. Mol. Life Sci., 68, 3635, 10.1007/s00018-011-0822-3 · DOI
  58. Johansson, 2008, The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria, Proc. Natl. Acad. Sci. U.S.A., 105, 15064, 10.1073/pnas.0803124105 · DOI · Paper page
  59. Gibson, 2005, Reinforcing the mucus: a new therapeutic approach for ulcerative colitis?, Gut, 54, 900, 10.1136/gut.2004.058453 · DOI
  60. Ehehalt, 2004, Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoElectrospray-tandem mass spectrometry, Scand. J. Gastroenterol., 39, 737, 10.1080/00365520410006233 · DOI
  61. Pullan, 1994, Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis, Gut, 35, 353, 10.1136/gut.35.3.353 · DOI
  62. Tytgat, 1996, Quantitative analysis of MUC2 synthesis in ulcerative colitis, Biochem. Biophys. Res. Commun., 224, 397, 10.1006/bbrc.1996.1039 · DOI
  63. Larsson, 2011, Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation, Inflamm. Bowel Dis., 17, 2299, 10.1002/ibd.21625 · DOI
  64. Corfield, 1996, Colonic mucins in ulcerative colitis: evidence for loss of sulfation, Glycoconj. J., 13, 809, 10.1007/BF00702345 · DOI
  65. Van der Sluis, 2006, Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection, Gastroenterology, 131, 117, 10.1053/j.gastro.2006.04.020 · DOI · Paper page
  66. Burger-van Paassen, 2011, Colitis development during the suckling–weaning transition in mucin Muc2-deficient mice, Am. J. Physiol. Gastrointest. Liver Physiol., 301, G667, 10.1152/ajpgi.00199.2010 · DOI
  67. Fu, 2011, Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice, J. Clin. Investig., 121, 1657, 10.1172/JCI45538 · DOI · Paper page
  68. Stremmel, 2005, Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis, Gut, 54, 966, 10.1136/gut.2004.052316 · DOI
  69. Stremmel, 2010, Phosphatidylcholine (lecithin) and the mucus layer: Evidence of therapeutic efficacy in ulcerative colitis?, Dig. Dis., 28, 490, 10.1159/000320407 · DOI
  70. Stremmel, 2007, Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial, Ann. Intern. Med., 147, 603, 10.7326/0003-4819-147-9-200711060-00004 · DOI
  71. Soga, 2008, Alteration of the expression profiles of acidic mucin, sialytransferase and sulfotransferases in the intestinal epithelium of rats infected with the nematode Nippostrongylus brasiliensis, Parasitol. Res., 103, 1427, 10.1007/s00436-008-1152-8 · DOI
  72. Hasnain, 2011, Muc5ac: a critical component mediating the rejection of enteric nematodes, J. Exp. Med., 208, 893, 10.1084/jem.20102057 · DOI
  73. Herbert, 2009, Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection, J. Exp. Med., 206, 2947, 10.1084/jem.20091268 · DOI
  74. Artis, 2004, RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract, Proc. Natl. Acad. Sci. U.S.A., 101, 13596, 10.1073/pnas.0404034101 · DOI
  75. Hogan, 2006, Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility, J. Allergy Clin. Immunol., 118, 257, 10.1016/j.jaci.2006.04.039 · DOI
  76. Krimi, 2008, Resistin-like molecule beta regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice, Inflamm. Bowel Dis., 14, 931, 10.1002/ibd.20420 · DOI
  77. Hill, 2010, Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis, Mucosal Immunol., 3, 148, 10.1038/mi.2009.132 · DOI
  78. Johansson, 2011, Microbiology. Keeping bacteria at a distance, Science, 334, 182, 10.1126/science.1213909 · DOI
  79. Vaishnava, 2011, The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine, Science, 334, 255, 10.1126/science.1209791 · DOI · Paper page
  80. Walk, 2010, Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus, Inflamm. Bowel Dis., 16, 1841, 10.1002/ibd.21299 · DOI
  81. Hayes, 2010, Exploitation of the intestinal microflora by the parasitic nematode Trichuris muris, Science, 328, 1391, 10.1126/science.1187703 · DOI

Cited by

Sorted by citations

See all 59

Metadata

Authors
Wolff, M. J., Broadhurst, M. J., & Loke, P.
Venue
Trends in Parasitology
Publisher
Elsevier BV
Published
2012-05
Volume
28
Issue
5
Pages
187-194
ISSN
1471-4922
Cited by
59
References
4
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Helminthic therapy: improving mucosal barrier function. https://app.cochat.ai/papers/10.1016/j.pt.2012.02.008
The paper
Wolff, M. J., Broadhurst, M. J., & Loke, P. (2012). Helminthic therapy: improving mucosal barrier function. Trends in Parasitology. https://doi.org/10.1016/j.pt.2012.02.008