Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis
Abstract
There is conflicting evidence regarding the effect of raised body mass index (BMI) on the outcome of assisted reproductive technology. In particular, there is insufficient evidence to describe the effect of BMI on live birth rates. We carried out a systematic review and meta-analysis of studies to evaluate the effect of raised BMI on treatment outcome following IVF/ICSI treatment. Subgroup analysis on overweight and obese patients was performed. Literature searches were conducted on MEDLINE, EMBASE and the Web of Science from 1966 to 2010. Thirty-three studies including 47,967 treatment cycles were included. Results indicated that women who were overweight or obese (BMI ≥ 25) had significantly lower clinical pregnancy (RR=0.90, P<0.0001) and live birth rates (RR=0.84, P=0.0002) and significantly higher miscarriage rate (RR=1.31, P < 0.0001) compared to women with a BMI < 25 following treatment. A subgroup analysis of overweight women (BMI ≥ 25-29.9) revealed lower clinical pregnancy (RR=0.91, P=0.0003) and live birth rates (RR=0.91, P=0.01) and higher miscarriage rate (RR=1.24, P < 0.00001) compared to women with normal weight (BMI < 25). In conclusion, raised BMI is associated with adverse pregnancy outcome in women undergoing IVF/ICSI treatment, including lower live birth rates. This effect is present in overweight as well as obese women.
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Fertility treatment success is lower in overweight or obese men and women than in normal-weight couples.
“Indeed, fertility treatment is less successful in men and women who are overweight or obese as compared with normal weight couples (Campbell 2015, Rittenberg 2011).”
From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Rittenberg 2011
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- Authors
- Rittenberg, V., Seshadri, S., Sunkara, S. K., Sobaleva, S., Oteng-Ntim, E., & El-Toukhy, T.
- Affiliations
- Guy's Hospital (GB)
- Venue
- Reproductive BioMedicine Online
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 23
- Issue
- 4
- Pages
- 421-439
- ISSN
- 1472-6483 (ISSN-L)
- OpenAlex
- W1985854926
- Cited by
- 428
- References
- 92
- Citations by year
- 2026: 19 · 2025: 14 · 2024: 29 · 2023: 35 · 2022: 36 · 2021: 34 · 2020: 36 · 2019: 39 · 2018: 31 · 2017: 39 · 2016: 34 · 2015: 32 · 2014: 23 · 2013: 16 · 2012: 7
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive BioMedicine Online (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- body mass index, obesity, overweight, in vitro fertilization, intracytoplasmic sperm injection, assisted reproduction, live birth rate, clinical pregnancy, miscarriage, pregnancy outcomes
- MeSH terms
- Abortion, Spontaneous, Female, Fertilization in Vitro, Gonadotropins, Humans, Infertility, Female, Obesity, Pregnancy, Pregnancy Outcome, Body Mass Index, Pregnancy Rate, Sperm Injections, Intracytoplasmic, Overweight, Live Birth, Oocyte Retrieval
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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