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Cited by 479Ovarian function and disordersReproductive Biology and FertilityReproductive Physiology in Livestock

Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence

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Qiao, J., Feng, H. L.·2011·Human Reproduction Update
DOI 10.1093/humupd/dmq032PMC PMC3001338
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Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and heterogeneous endocrine disorder in women of reproductive age. Although patients with PCOS are typically characterized by increased numbers of oocytes retrieved during IVF, they are often of poor quality, leading to lower fertilization, cleavage and implantation rates, and a higher miscarriage rate. METHODS: For this review, we searched the database MEDLINE (1950 to January 2010) and Google for all full texts and/or abstract articles published in English with content related to oocyte maturation and embryo developmental competence. RESULTS: The search showed that alteration of many factors may directly or indirectly impair the competence of maturating oocytes through endocrine and local paracrine/autocrine actions, resulting in a lower pregnancy rate in patients with PCOS. The extra-ovarian factors identified included gonadotrophins, hyperandrogenemia and hyperinsulinemia, although intra-ovarian factors included members of the epidermal, fibroblast, insulin-like and neurotrophin families of growth factors, as well as the cytokines. CONCLUSIONS: Any abnormality in the extra- and/or intra-ovarian factors may negatively affect the granulosa cell-oocyte interaction, oocyte maturation and potential embryonic developmental competence, contributing to unsuccessful outcomes for patients with PCOS who are undergoing assisted reproduction.

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Authors
Qiao, J., & Feng, H. L.
Affiliations
  • Peking University Third Hospital (CN)
  • North Shore University Hospital (US)
Corresponding author
  • Qiao, J.
  • Feng, H. L.
ORCID
Venue
Human Reproduction Update
Publisher
Oxford University Press (OUP)
Published
2010-07-16
Volume
17
Issue
1
Pages
17-33
ISSN
  • 1355-4786 (ISSN-L)
  • 1460-2369
DOI
10.1093/humupd/dmq032
PMC
PMC3001338
OpenAlex
W2142003876
Cited by
479
References
11
Citations by year
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FWCI
2.13
Type
journal article
Language
en
Open access
Locations
  • Human Reproduction Update (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
Keywords
polycystic ovary syndrome, oocyte maturation, embryo developmental competence, hyperandrogenemia, hyperinsulinemia, gonadotropins, autocrine and paracrine signaling, growth factors, cytokines, assisted reproduction outcomes
MeSH terms
Female, Follicle Stimulating Hormone, Humans, Hyperinsulinism, Luteinizing Hormone, Oocytes, Ovary, Polycystic Ovary Syndrome, Pregnancy, Hyperandrogenism, Paracrine Communication, Intercellular Signaling Peptides and Proteins, Embryonic Development

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