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Cited by 676

The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

Open access
Yan, Mingzhu, Huo, Yazhen, Yin, Shutao, Hu, Hongbo·2018·Redox Biology
DOI 10.1016/j.redox.2018.04.019
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Abstract

Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in many developed countries. Mitochondrial oxidative stress is considered to be the predominant cellular event in APAP-induced liver injury. Accordingly, N-acetyl cysteine, a known scavenger of reactive oxygen species (ROS), is recommended as an effective clinical antidote against APAP-induced acute liver injury (AILI) when it is given at an early phase; however, the narrow therapeutic window limits its use. Hence, the development of novel therapeutic approaches that can offer broadly protective effects against AILI is clearly needed. To this end, it is necessary to better understand the mechanisms of APAP hepatotoxicity. Up to now, in addition to mitochondrial oxidative stress, many other cellular processes, including phase I/phase II metabolism, endoplasmic reticulum stress, autophagy, sterile inflammation, microcirculatory dysfunction, and liver regeneration, have been identified to be involved in the pathogenesis of AILI, providing new targets for developing more effective therapeutic interventions against APAP-induced liver injury. In this review, we summarize intracellular and extracellular events involved in APAP hepatotoxicity, along with emphatic discussions on the possible therapeutic approaches targeting these different cellular events.

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Metadata

Authors
Yan, M., Huo, Y., Yin, S., & Hu, H.
Venue
Redox Biology
Publisher
Elsevier BV
Published
2018-07
Volume
17
Pages
274-283
ISSN
2213-2317 (ISSN-L)
DOI
10.1016/j.redox.2018.04.019
OpenAlex
W2800988230
Cited by
676
References
127
FWCI
37.07
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. https://app.cochat.ai/papers/10.1016/j.redox.2018.04.019
The paper
Yan, M., Huo, Y., Yin, S., & Hu, H. (2018). Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox Biology. https://doi.org/10.1016/j.redox.2018.04.019

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.