The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress
Open accessAbstract
Current management of liver ischemia-reperfusion (I/R) injury is mainly based on supportive care and no specific treatment is available. Irisin, a recently identified hormone, plays pivotal roles in energy expenditure and oxidative metabolism; however, it remains unknown whether irisin has any protective effects on hepatic I/R injury. In this study, we found that serum and liver irisin levels were markedly decreased at 24 h after hepatic I/R. Treatment with exogenous irisin improved liver function, reduced liver necrosis and cell apoptosis, and relieved inflammatory response after hepatic I/R. Meanwhile, exogenous irisin markedly inhibited mitochondrial fission related protein dynamin related protein 1 (drp-1) and fission 1 (Fis-1) expression in hepatic I/R. Additionally, treatment with exogenous irisin increased mitochondrial content and increased mitochondrial biogenesis related peroxisome proliferative activated receptor-γ (PPARγ) co-activator 1α (PGC-1α) and mitochondrial transcription factor (TFAM) expression. Furthermore, irisin decreased oxidative stress by upregulating uncoupling proteins (UCP) 2 expression in hepatic I/R. The results reveal that treatment with exogenous irisin alleviated hepatic I/R injury by restraining mitochondrial fission, promoting mitochondrial biogenesis and relieving oxidative stress. Irisin treatment appears to be a novel and promising therapeutic approach for hepatic I/R injury.
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Cited by
Shi, J., Yu, T., Song, K., Du, S., He, S., Hu, X., Li, X., Li, H., Dong, S., Zhang, Y., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101954 · Cited by 264
Progress and Challenges in the Biology of FNDC5 and Irisin
Maak, S., Norheim, F., Drevon, C. A., & Erickson, H. P. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab003 · Cited by 247
Bi, J., Zhang, J., Ren, Y., Du, Z., Li, T., Wang, T., Zhang, L., Wang, M., Wu, Z., Lv, Y., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14811 · Cited by 113
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Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process
Zhang, H., Wu, X., Liang, J., Kirberger, M., & Chen, N. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101680 · Cited by 88
Metadata
- Authors
- Bi, J., Zhang, J., Ren, Y., Du, Z., Li, Q., Wang, Y., Wei, S., Yang, L., Zhang, J., Liu, C., Lv, Y., & Wu, R.
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 20
- Pages
- 296-306
- ISSN
- 2213-2317 (ISSN-L)
- OpenAlex
- W2898334602
- Cited by
- 286
- References
- 43
- FWCI
- 20.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bi, J., Zhang, J., Ren, Y., Du, Z., Li, Q., Wang, Y., Wei, S., Yang, L., Zhang, J., Liu, C., Lv, Y., & Wu, R. (2019). Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress. Redox Biology. https://doi.org/10.1016/j.redox.2018.10.019
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