The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

Siraki, Arno G.

doi:10.1016/j.redox.2021.102109

Cited by 150Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressBioactive Compounds and Antitumor Agents

The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

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Siraki, Arno G.·2021·Redox Biology

DOI 10.1016/j.redox.2021.102109PMC PMC8403760

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Abstract

This review provides a practical guide to myeloperoxidase (MPO) and presents to the reader the diversity of its presence in biology. The review provides a historical background, from peroxidase activity to the discovery of MPO, to its role in disease and drug development. MPO is discussed in terms of its necessity, as specific individuals lack MPO expression. An underlying theme presented throughout brings up the question of the benefit and burden of MPO activity. Enzyme structure is discussed, including accurate masses and glycosylation sites. The catalytic cycle of MPO and its corresponding pathways are presented, with a discussion of the importance of the redox couples of the different states of MPO. Cell lines expressing MPO are discussed and practically summarized for the reader, and locations of MPO (primary and secondary) are provided. Useful methods of MPO detection are discussed, and how these can be used for studying disease processes are implied through the presentation of MPO as a biomarker. The presence of MPO in neutrophil extracellular traps is presented, and the activators of the former are provided. Lastly, the transition from drug metabolism to a target for drug development is where the review concludes.

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Hypochlorous acid is an important inorganic bactericidal molecule present in the innate immune system, effective against a wide range of micro-organisms.
“The most common of these acids is hypochlorous acid, an important inorganic bactericidal molecule present in the innate immune system, which is effective against a wide range of micro-organisms [147].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [147]

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MYELOPEROXIDASE: NEW ROLES FOR AN OLD MOLECULE MIJELOPEROKSIDAZA: NOVE ULOGE STAROG MOLEKULA
Stankovi, S. (2011)

Authors: Siraki, A. G.
Affiliations: University of Alberta (CA)
Corresponding author: Siraki, Arno G.
ORCID: Siraki, Arno G.
Venue: Redox Biology
Publisher: Elsevier BV
Published: 2021-10
Volume: 46
Pages: 102109
ISSN: 2213-2317 (ISSN-L)
DOI: 10.1016/j.redox.2021.102109
PMC: PMC8403760
OpenAlex: W3195599952
Cited by: 150
References: 197
Citations by year: 2026: 32 · 2025: 36 · 2024: 36 · 2023: 28 · 2022: 17 · 2021: 1
FWCI: 2.10
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Redox Biology (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Natural Sciences and Engineering Research Council of Canada (RGPIN-2014-04878, RGPIN-2020-06305)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: myeloperoxidase, inflammation, immunity, biomarkers, drug metabolism, drug discovery, redox couples, neutrophil extracellular traps
MeSH terms: Pharmaceutical Preparations, Humans, Inflammation, Peroxidase, Neutrophils, Biomarkers, Drug Discovery

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The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

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