Cited by 416Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Myeloperoxidase-derived oxidation: Mechanisms of biological damage and its prevention

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Davies, Michael J.·2010·Journal of Clinical Biochemistry and Nutrition

Abstract

There is considerable interest in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide range of human pathologies. This has been sparked by rapid developments in our understanding of the basic biochemistry of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of biomarkers that can be used damage induced by these oxidants in vivo, and the recent identification of a number of compounds that show promise as inhibitors of these enzymes. Such compounds offer the possibility of modulating damage in a number of human pathologies. This reviews recent developments in our understanding of the biochemistry of myeloperoxidase, the oxidants that this enzyme generates, and the use of inhibitors to inhibit such damage.

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Crossref · 10.3164/jcbn.11-006fr

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  • HOCl is a very reactive and oxidizing agent, can act as a chlorinating agent, and is the main strong oxidant generated by neutrophils in appreciable quantities.

    “The reaction catalyzed by MPO is the oxidation of the Cl− anion by H2O2 to give hypochlorous acid HOCl, a very reactive and oxidizing agent, which can also act as a chlorinating agent and is the main strong oxidant generated by neutrophils in appreciable quantities [30].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [30]

  • Myeloperoxidase MPO catalyzes the oxidation of Cl− by H2O2 to give hypochlorous acid HOCl.

    “The reaction catalyzed by MPO is the oxidation of the Cl− anion by H2O2 to give hypochlorous acid HOCl, a very reactive and oxidizing agent, which can also act as a chlorinating agent and is the main strong oxidant generated by neutrophils in appreciable quantities [30].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [30]

  • Hypochlorous acid HOCl and hypothiocyanous acid HOSCN are important inorganic bactericidal molecules effective against a wide range of microbes.

    “Hypochlorous acid HOCl and hypothiocyanous acid HOSCN synthesized through the enzyme myeloperoxidase MPO, which catalyzes the reaction between H2O2 and Cl− or SCN−, are important inorganic bactericidal molecules, effective against a wide range of microbes.”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [30]

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Research works printed but not linked: 2

  1. [174]Lentner C Geigy Scientific Tables vol. 3: Physical Chemistry, Composition of Blood, Hematology, Somatometric Data Basle Ciba-Geigy Ltd 1984
  2. [226]Kettle AJ Gedye CA Winterbourn CC Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide Biochem J 1997 321 503 508 9020887 PMC1218097

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Authors
Davies, M. J.
Affiliations
The University of Sydney (AU)
Corresponding author
Davies, Michael J.
Venue
Journal of Clinical Biochemistry and Nutrition
Published
2010
Volume
48
Issue
1
Pages
8-19
ISSN
  • 0912-0009 (ISSN-L)
  • 1880-5086
OpenAlex
W2028031080
Cited by
412
References
227
Citations by year
2026: 18 · 2025: 15 · 2024: 31 · 2023: 30 · 2022: 34 · 2021: 40 · 2020: 41 · 2019: 37 · 2018: 27 · 2017: 29 · 2016: 23 · 2015: 21 · 2014: 19 · 2013: 16 · 2012: 24
FWCI
6.45
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Biochemistry and Nutrition (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fondation pour la Recherche Médicale
  • Medical Research Council
  • Australian Research Council (CE0561607, DP0988311)
  • National Health and Medical Research Council (570829)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
myeloperoxidase, heme peroxidase, eosinophil peroxidase, lactoperoxidase, oxidative damage, oxidative damage biomarkers, enzyme inhibitors

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