The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells
Open accessAbstract
Apelin, the proposed endogenous peptide ligand of the novel G-protein-coupled receptor APJ, has been shown to possess potent vasodilator and positive inotropic effects in rats and humans in vivo. However, in humans, no endogenous source of apelin has been reported. Therefore, based on the presence of APJ and mRNA encoding apelin in human tissues, we investigated the expression of apelin in fresh-frozen human tissue from right atrium, left ventricle, lung, kidney, adrenal and large conduit vessels using immunocytochemistry. Apelin-like immunoreactivity (apelin-LI) was detected in vascular endothelial cells lining blood vessels in the human heart, kidney, adrenal gland and lung and in endothelial cells of large conduit vessels. Apelin-LI was also present in endocardial endothelial cells lining recesses of the right atrium. Apelin-LI was not present or below the level of detection in cardiomyocytes, Purkinje's cells, pulmonary or renal epithelial cells, secretory cells of the adrenal gland, vascular smooth muscle cells, adipocytes, nerves and connective tissue. The restricted presence of apelin-LI in endothelial cells suggests that endothelial apelin may play a role as a locally secreted cardiovascular mediator acting on APJ receptors present on the vascular smooth muscle and on cardiac myocytes to regulate vascular tone and cardiac contractility.
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Citations
Cites
Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor
Tatemoto, K., Hosoya, M., Habata, Y., Fujii, R., Kakegawa, T., Zou, M.-X., Kawamata, Y., Fukusumi, S., Hinuma, S., Kitada, C., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9489 · Cited by 1,685
O'Dowd, B. F., Heiber, M., Chan, A., Heng, H. H. Q., Tsui, L.-C., Kennedy, J. L., Shi, X., Petronis, A., George, S. R., & Nguyen, T. (1993) · Gene · doi:10.1016/0378-1119(93)90495-o · Cited by 851
Characterization of Apelin, the Ligand for the APJ Receptor
Lee, D. K., Cheng, R., Nguyen, T., Fan, T., Kariyawasam, A. P., Liu, Y., Osmond, D. H., George, S. R., & O'Dowd, B. F. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740034.x · Cited by 682
The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism
Tatemoto, K., Takayama, K., Zou, M.-X., Kumaki, I., Zhang, W., Kumano, K., & Fujimiya, M. (2001) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00236-1 · Cited by 640
Apelin, the Novel Endogenous Ligand of the Orphan Receptor APJ, Regulates Cardiac Contractility
Szokodi, I., Tavi, P., Földes, G., Voutilainen-Myllylä, S., Ilves, M., Tokola, H., Pikkarainen, S., Piuhola, J., Rysä, J., Tóth, M., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000033522.37861.69 · Cited by 625
Molecular properties of apelin: tissue distribution and receptor binding
Kawamata, Y., Habata, Y., Fukusumi, S., Hosoya, M., Fujii, R., Hinuma, S., Nishizawa, N., Kitada, C., Onda, H., Nishimura, O., et al. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(00)00143-9 · Cited by 521
Molecular and Functional Characteristics of APJ
Hosoya, M., Kawamata, Y., Fukusumi, S., Fujii, R., Habata, Y., Hinuma, S., Kitada, C., Honda, S., Kurokawa, T., Onda, H., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908417199 · Cited by 483
Medhurst, A. D., Jennings, C. A., Robbins, M. J., Davis, R. P., Ellis, C., Winborn, K. Y., Lawrie, K. W. M., Hervieu, G., Riley, G., Bolaky, J. E., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01587.x · Cited by 448
Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain
Reaux, A., De Mota, N., Skultetyova, I., Lenkei, Z., El Messari, S., Gallatz, K., Corvol, P., Palkovits, M., & Llorens‐Cortès, C. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00320.x · Cited by 374
Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum
Habata, Y., Fujii, R., Hosoya, M., Fukusumi, S., Kawamata, Y., Hinuma, S., Kitada, C., Nishizawa, N., Murosaki, S., Kurokawa, T., et al. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00114-7 · Cited by 359
Cited by
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis
O'Carroll, A.-M., Lolait, S. J., Harris, L. E., & Pope, G. R. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0227 · Cited by 344
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
Chun, H. J., Ali, Z. A., Kojima, Y., Kundu, R. K., Sheikh, A. Y., Agrawal, R., Zheng, L., Leeper, N. J., Pearl, N. E., Patterson, A. J., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34871 · Cited by 329
Maguire, J. J., Kleinz, M. J., Pitkin, S. L., & Davenport, A. P. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.134619 · Cited by 323
Self-citationKidoya, H., Ueno, M., Yamada, Y., Mochizuki, N., Nakata, M., Yano, T., Fujii, R., & Takakura, N. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601982 · Cited by 265
Cardiac Nonmyocytes in the Hub of Cardiac Hypertrophy
Kamo, T., Akazawa, H., & Komuro, I. (2015) · Circulation Research · doi:10.1161/circresaha.117.305349 · Cited by 171
Metadata
- Authors
- Kleinz, M. J., & Davenport, A. P.
- Venue
- Regulatory Peptides
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 118
- Issue
- 3
- Pages
- 119-125
- ISSN
- 0167-0115 (ISSN-L)
- OpenAlex
- W2132257581
- Cited by
- 288
- References
- 17
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- green
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