The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Function of opioids in the enteric nervous system
Abstract
Alterations in gastrointestinal motility and secretion underlie the constipating action of therapeutically administered opiates. The prototype opiate is morphine, which acts to delay gastric emptying and intestinal transit, to suppress intestinal secretion of water and electrolytes and to suppress transport of bile into the duodenum. The effects of opiates, synthetic opioids and endogenously released opioid peptides on these organ‐level gastrointestinal functions reflect actions on electrical and synaptic behaviour of neurones in the enteric nervous system. Adverse effects and positive therapeutic effects of administration of opioid‐receptor‐blocking drugs on the digestive tract must be understood in the context of the neurophysiology of the enteric nervous system and mechanisms of neural control of gastrointestinal smooth muscle, secretory glands and blood–lymphatic vasculature. We review here the integrated systems of physiology and cellular neurobiology that are basic to understanding the actions of opioid agonists and antagonists in the digestive tract.
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Cites
Claing, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00023-5 · Cited by 519
Cited by
Opioid receptors in the gastrointestinal tract
Holzer, P. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.03.012 · Cited by 377
Opioids in gastroenterology: treating adverse effects and creating therapeutic benefits
Camilleri, M., Lembo, A., & Katzka, D. A. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.05.014 · Cited by 176
“These differences may also reflect varying densities of opiate receptors that are organ specific in the gut.(35) The exact mechanism of tolerance in humans is unclear, although the prevailing hypotheses are either dephosphorylation, which leads to activation of the receptor to bind an agonist,(14) or binding of b-arre…”
Ileal brake: Neuropeptidergic control of intestinal transit
Van Citters, G. W., & Lin, H. C. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0021-9 · Cited by 144
Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction
Leppert, W. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s32684 · Cited by 72
Thwaites, P. A., Gibson, P. R., & Burgell, R. E. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15927 · Cited by 59
Metadata
- Authors
- Wood, J. D., & Galligan, J. J.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2004-09-08
- Volume
- 16
- Issue
- s2
- Pages
- 17-28
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2066869240
- Cited by
- 371
- References
- 1
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
