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Long-term neurological outcomes in out-of-hospital cardiac arrest patients treated with targeted-temperature management
Abstract
Background This study aimed to assess long-term cognitive and functional outcomes in out-of-hospital cardiac arrest (OHCA) patients treated with targeted-temperature management, investigate the existence of prognostic factors that could be assessed during initial admission and evaluate the usefulness of classic neurological scales in this clinical scenario. Methods Patients admitted due to OHCA from August 2007 to November 2015 and surviving at least one year were included. Each patient completed a structured interview focused on the collection of clinical, social and demographic data. All available information in clinical records was reviewed and a battery of neurocognitive and psychometric tests was performed. Results Seventy-nine patients were finally included in the analysis. Forty-three patients (54.4%) scored below the usual cut-off points for the diagnosis of mild cognitive impairment, even though most of these deficits went unnoticed when patients were assessed using CPC and modified Rankin scale. Nineteen (24%) developed certain degree of impairment in their attention capacity and executive functions. A significant proportion developed new memory-related disorders (43%), depressive symptoms (17.7%), aggressive/uninhibited behavior (12.7%) and emotional lability (8.9%). A greater number of weekly hours of intellectual activity and a qualified job were independent protective factors for the development of cognitive impairment. However, being older at the time of the cardiac arrest was identified as a poor prognostic factor. Conclusions There is a high prevalence of long-term cognitive deficits and functional limitations in OHCA survivors. Most commonly used clinical scales in clinical practice are crude and lack sensitivity to detect most of these deficits.
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“Notably, device-related emergency research may confer considerable benefit in terms of leading to improvements in clinical practice and patient outcomes. 321”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [321]
Citations
Cites
The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53221.x · Cited by 25,553
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591
Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest.
Nozari, A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012689 · Cited by 8,536
ASSESSMENT OF OUTCOME AFTER SEVERE BRAIN DAMAGE A Practical Scale
JENNETT, B. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92830-5 · Cited by 7,501
Relatives of the Impaired Elderly: Correlates of Feelings of Burden
Zarit, S. H., Reever, K. E., & Bach-Peterson, J. (1980) · The Gerontologist · doi:10.1093/geront/20.6.649 · Cited by 5,810
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
Bernard, S. A., Gray, T. W., Buist, M., Jones, B. M., Silvester, W., Gutteridge, G. A., & Smith, K. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa003289 · Cited by 5,426
Trail Making Test A and B: normative data stratified by age and education
Tombaugh, T. (2004) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(03)00039-8 · Cited by 3,239
Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest
Nielsen, N., Wetterslev, J., Cronberg, T., Erlinge, D., Gasche, Y., Hassager, C., Horn, J., Hovdenes, J., Kjaergaard, J., Kuiper, M., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1310519 · Cited by 2,766
Callaway, C. W., Donnino, M. W., Fink, E. L., Geocadin, R. G., Golan, E., Kern, K. B., Leary, M., Meurer, W. J., Peberdy, M. A., Thompson, T. M., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000262 · Cited by 1,241
The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results.
Farrell, B., Godwin, J., Richards, S., & Warlow, C. (1991) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.54.12.1044 · Cited by 1,203
Jorm, A. F., & Jacomb, P. A. (1989) · Psychological Medicine · doi:10.1017/s0033291700005742 · Cited by 1,114
Mode of death after admission to an intensive care unit following cardiac arrest
Laver, S., Farrow, C., Turner, D., & Nolan, J. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2425-z · Cited by 986
Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a “two-hit” model
Sekhon, M. S., Ainslie, P. N., & Griesdale, D. E. (2017) · Critical Care · doi:10.1186/s13054-017-1670-9 · Cited by 593
Kirkegaard, H., Søreide, E., de Haas, I., Pettilä, V., Taccone, F. S., Arus, U., Storm, C., Hassager, C., Nielsen, J. F., Sørensen, C. A., et al. (2017) · JAMA · doi:10.1001/jama.2017.8978 · Cited by 359
Dragancea, I., Rundgren, M., Englund, E. M., Friberg, H., & Cronberg, T. (2012) · Resuscitation · doi:10.1016/j.resuscitation.2012.09.015 · Cited by 334
Peña‐Casanova, J., Quiñones-Úbeda, S., Quintana-Aparicio, M., Aguilar, M., Badenes, D., Molinuevo, J. L., Torner, L., Robles, A., Barquero, M. S., Villanueva, C., et al. (2009) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acp038 · Cited by 251
Rittenberger, J. C., Raina, K. D., Holm, M. B., Kim, Y. J., & Callaway, C. W. (2011) · Resuscitation · doi:10.1016/j.resuscitation.2011.03.034 · Cited by 235
Cronberg, T., Lilja, G., Horn, J., Kjærgaard, J., Wise, M. P., Pellis, T., Hovdenes, J., Gasche, Y., Åneman, A., Stammet, P., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0169 · Cited by 187
Lilja, G., Nielsen, N., Friberg, H., Horn, J., Kjærgaard, J., Nilsson, F., Pellis, T., Wetterslev, J., Wise, M. P., Bosch, F. H., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.014414 · Cited by 182
Moulaert, V. R. M., Heugten, C. M. V., Winkens, B., Bakx, W. G. M., de Krom, M. C. T. F. M., Gorgels, T., Wade, D. T., & Verbunt, J. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.229 · Cited by 164
Hypothermia in Comatose Survivors From Out-of-Hospital Cardiac Arrest
de Sá, E. L., Rey, J. R., Armada, E., Salinas, P., Viana‐Tejedor, A., Espinosa-García, S., Martinez-Moreno, M., Corral, E., & Lopez-Sendon, J. L. (2012) · Circulation · doi:10.1161/circulationaha.112.136408 · Cited by 145
Self-citationAnxiety and depression among out-of-hospital cardiac arrest survivors
Lilja, G., Nilsson, G., Nielsen, N., Friberg, H., Hassager, C., Koopmans, M., Kuiper, M. A., Martini, A., Mellinghoff, J., Pelosi, P. P., et al. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.09.389 · Cited by 109
Hsu*, J. W., Madsen, C., & Callaham, M. L. (1996) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(96)70080-x · Cited by 104
Tamayo, F., Casals-Coll, M., Sánchez‐Benavides, G., Quintana, M., Manero, R. M., Rognoni, T., Calvo, L., Palomo, R., Aranciva, F., & Peña‐Casanova, J. (2012) · Neurología · doi:10.1016/j.nrl.2011.12.020 · Cited by 82
del Pozo, N. O., Pino, R. D., Ibarretxe‐Bilbao, N., Schretlen, D. J., & Lasa, J. P. (2016) · Revista de Neurología · doi:10.33588/rn.6311.2016241 · Cited by 78
Neurological prognostication after cardiac arrest
Sandroni, C., & Geocadin, R. G. (2015) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000202 · Cited by 66
Cognitive outcomes of patients undergoing therapeutic hypothermia after cardiac arrest
Fugate, J. E., Moore, S. A., Knopman, D. S., Claassen, D. O., Wijdicks, E. F. M., White, R. D., & Rabinstein, A. A. (2013) · Neurology · doi:10.1212/wnl.0b013e318297ee7e · Cited by 63
Björklund, E., Lindberg, E., Rundgren, M., Cronberg, T., Friberg, H., & Englund, E. M. (2013) · Resuscitation · doi:10.1016/j.resuscitation.2013.11.022 · Cited by 61
Tiainen, M., Vaahersalo, J., Skrifvars, M. B., Hästbacka, J., Grönlund, J., & Pettilä, V. (2018) · Resuscitation · doi:10.1016/j.resuscitation.2018.05.011 · Cited by 43
Polanowska, K., Sarzyńska-Długosz, I. M., Paprot, A. E., Sikorska, Ś., Seniów, J. B., Karpiński, G., Kowalik, R., Opolski, G., & Członkowska, A. (2014) · Kardiologia Polska · doi:10.5603/kp.a2014.0087 · Cited by 41
Determinants of cognitive outcome in survivors of out-of-hospital cardiac arrest
Ørbo, M. C., Aslaksen, P. M., Larsby, K. E., Norli, L., Schäfer, C., Tande, P. M., Vangberg, T. R., & Anke, A. (2014) · Resuscitation · doi:10.1016/j.resuscitation.2014.08.010 · Cited by 38
Wallin, E., Larsson, I., Rubertsson, S., & Kristofferzon, M. (2014) · Resuscitation · doi:10.1016/j.resuscitation.2013.12.020 · Cited by 26
In-hospital mortality in 13,263 survivors of out-of-hospital cardiac arrest in Canada
Redpath, C. J., Sambell, C., Stiell, I. G., Johansen, H., Williams, K., Samie, R., Green, M. S., Gollob, M. H., Lemery, R., & Birnie, D. H. (2010) · American Heart Journal · doi:10.1016/j.ahj.2009.12.030 · Cited by 16
Dent, B. M. (2015) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2015.07.004 · Cited by 6
Caro‐Codón, J., Rey, J. R., de Sá, E. L., Fernández, Ó. G., Rosillo, S. O., Armada, E., Iniesta, Á. M., de Bobadilla, J. F., Cantador, J. R., Sotelo, L. R., et al. (2018) · Data in Brief · doi:10.1016/j.dib.2018.10.086 · Cited by 2
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European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions
Mentzelopoulos, S. D., Couper, K., Voorde, P. V. D., Druwé, P., Blom, M., Perkins, G. D., Lulic, I., Djakow, J., Raffay, V., Lilja, G., et al. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.02.017 · Cited by 246
Metadata
- Authors
- Caro-Codón, J., Rey, J. R., Lopez-de-Sa, E., González Fernández, Ó., Rosillo, S. O., Armada, E., Iniesta, Á. M., Fernández de Bobadilla, J., Ruiz Cantador, J., Rodríguez Sotelo, L., Irazusta, F. J., Rial Bastón, V., Merás Colunga, P., & López-Sendón, J. L.
- Affiliations
- Hospital Universitario La Paz (ES)
- Venue
- Resuscitation
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 133
- Pages
- 33-39
- ISSN
- 0300-9572 (ISSN-L)
- OpenAlex
- W2893577583
- Cited by
- 46
- References
- 37
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 1 · 2022: 5 · 2021: 18 · 2020: 2 · 2019: 4 · 2018: 1
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Resuscitation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Keywords
- out-of-hospital cardiac arrest, targeted temperature management, post-cardiac arrest syndrome, long-term neurological outcome, cognitive impairment, functional disability, mild cognitive impairment, memory impairment, depressive symptoms, aggression, emotional lability, prognostic factors, intellectual activity, Coma Recovery Scale, modified Rankin Scale
- MeSH terms
- Mental Status and Dementia Tests, Adult, Age Factors, Aged, Aggression, Depression, Female, Humans, Hypothermia, Induced, Male, Memory Disorders, Middle Aged, Prospective Studies, Quality of Life, Time Factors, Prevalence, Outcome Assessment, Health Care, Survivors, Executive Function, Out-of-Hospital Cardiac Arrest, Cognitive Dysfunction
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