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Cited by 4Periodontal Regeneration and TreatmentsDental Implant Techniques and OutcomesEndodontics and Root Canal Treatments

Clinical outcomes of guided tissue regeneration with carbonate apatite granules and poly(lactic acid/caprolactone) membrane for the treatment of intrabony defects and mandibular Class II furcation involvements: A 12-month prospective pilot clinical study

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Okada, Munehiro, Fukuba, Shunsuke, Yamaki, Daichi, Iwata, Takanori·2024·Regenerative Therapy
DOI 10.1016/j.reth.2024.08.017PMC PMC11414539
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Abstract

For deep intrabony defects or Class II furcation involvements (FI), periodontal tissue regenerative therapy combined with bone graft materials and a barrier membrane is recommended. The objective of this study was to assess the safety and efficacy of using carbonate apatite (CO 3 Ap) granules and absorbable poly(lactic acid/caprolactone) (PLCL) membranes for periodontal regeneration in the treatment of intrabony defects and mandibular Class II FI. This prospective pilot clinical study, conducted at a single center with a single-arm design, aimed to assess the safety and efficacy of CO 3 Ap and PLCL membranes in patients with periodontitis. A total of 9 patients with 10 teeth, including seven deep intrabony defects and three Class II FI, were treated with CO 3 Ap granules and PLCL membranes. Clinical parameters such as probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), tooth mobility (Mo), Plaque Index (PI), and Gingival Index (GI) were assessed at baseline, 6 and 12 months post-surgery. Radiographic analysis was performed using dental X-rays and cone beam computed tomography (CBCT) images taken at baseline, 6, and 12 months post-surgery. Postoperative healing was uneventful in most of the cases. In some cases, membrane exposures were observed. However, there were no signs of inflammation, such as abnormal bleeding, pain, swelling, or pus. These exposures eventually healed well in the end. The mean reductions in PPD at 6 and 12 months were 4.5 ± 1.6 mm and 4.9 ± 1.4 mm, respectively, while the mean gains in CAL were 4.4 ± 1.7 mm at 6 months and 4.6 ± 1.2 mm at 12 months. Radiographic analysis showed improvements in linear bone height within intrabony defects and in the vertical subclassification of FI in Class II FI. Despite the limitations of this study, periodontal regenerative therapy using CO 3 Ap granules and a PLCL membrane demonstrated promising clinical safety and efficacy for treating intrabony defects and mandibular Class II furcation involvement. • This study conducted the first human pilot clinical trial of periodontal regenerative therapy using CO 3 Ap granules and PLCL membranes. • Periodontal regenerative therapy using CO 3 Ap and PLCL membranes resulted in clinical improvement in intrabony defects and Class II furcation involvement at both 6 and 12 months post-surgery.

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Crossref · 10.1016/j.reth.2024.08.017

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  • PLCL films prepared by solution casting usually have a relatively dense microstructure and good elasticity and flexibility.

    “The films prepared by this method usually have a relatively dense microstructure, so they have good elasticity and flexibility [48].”

    From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [48]

    The Introduction (page unavailable) describes a PLCL membrane with a compact outer layer, and the Discussion (page unavailable) describes it as elastic and stretchable. The paper does not say the membrane was made by solution casting, that solution-cast PLCL films usually have these properties, or that a dense structure causes their elasticity and flexibility. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • PLCL biomaterials used in deep tissues such as vascular stents tend to degrade faster than those used on the body surface such as wound dressings.

    “For example, PLCL biomaterials used in deep tissues (e.g., vascular stents) tend to degrade faster than those used on the body surface (e.g., wound dressings) [48].”

    From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [48]

    The Introduction says PLCL degradation can be adjusted by changing its composition, and the Discussion describes slow degradation of the periodontal membrane. Neither section compares degradation in deep tissues with degradation at the body surface or discusses vascular stents and wound dressings; searches for those applications and for implantation-site effects found no supporting passage. Page numbers are unavailable in our copy. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Authors
Okada, M., Fukuba, S., Yamaki, D., & Iwata, T.
Affiliations
Tokyo Medical and Dental University (JP)
Corresponding author
  • Fukuba, Shunsuke
  • Iwata, Takanori
ORCID
Venue
Regenerative Therapy
Publisher
Elsevier BV
Published
2024-06
Volume
26
Pages
767-774
ISSN
2352-3204 (ISSN-L)
DOI
10.1016/j.reth.2024.08.017
PMC
PMC11414539
OpenAlex
W4402356389
Cited by
4
References
40
Citations by year
2026: 3 · 2024: 1
FWCI
1.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Regenerative Therapy (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Tokyo Medical and Dental University
  • Japan Society for the Promotion of Science (23K15993)
Topics
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
  • Health Sciences › Dentistry › Oral Surgery › Endodontics and Root Canal Treatments
Keywords
guided tissue regeneration, intrabony defects, periodontal regeneration, periodontitis, bone graft substitutes, probing depth, clinical attachment level, mandibular teeth, cone-beam computed tomography, membrane exposure, tooth mobility

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