Fabrication of novel poly(lactic acid/caprolactone) bilayer membrane for GBR application
Abstract
Objective Guided bone regeneration (GBR) often involves the use of membranes as barriers for soft tissues. Commercially available membranes, however, do not possess an adequately low degradation rate, resulting in limited barrier function. The purpose of this study was to develop and assess the physicochemical and biological characteristics of a novel poly(l-lactic acid/caprolactone) (PLCL) bilayer membrane and determine its usefulness for GBR application.Methods The experimental bilayer membrane was prepared via a two-step freezing and lyophilization process with a PLCL solution. Next, the PLCL membrane was investigated regarding tensile strength, surface roughness, in vitro degradation and clinical operability. In addition, cell proliferation and differentiation were investigated on each layer of the experimental membrane. For all experiments, a commercially available poly(lactic-co-glycolic) acid membrane was used as a control.Results In vitro analysis of the PLCL bilayer membrane revealed suitable mechanical strength combined with high breaking strain, which contributed to membrane operability. In addition, the PLCL bilayer membrane had enhanced stability compared to the commercial control due to its slower degradation, and was capable of supporting cell growth and osteogenic differentiation.Significance The current study confirmed that the PLCL membrane possessed a high biocompatibility and slow degradation rate that contributes to prolonged barrier function and bone regeneration. Altogether, it was considered that the PLCL bilayer membrane developed in this study was applicable for GBR treatment.
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Residual surface organic solvents from solution casting may compromise material biosafety.
“However, this preparation method also has its shortcomings: the organic solvent introduced in the preparation process needs to be fully cleaned and removed; otherwise, residual surface organic solvents may compromise material biosafety [123].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [123]
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- Authors
- Abe, G. L., Sasaki, J.-I., Katata, C., Kohno, T., Tsuboi, R., Kitagawa, H., & Imazato, S.
- Affiliations
- The University of Osaka (JP)
- Corresponding author
- Sasaki, Jun-Ichi
- Venue
- Dental Materials
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 36
- Issue
- 5
- Pages
- 626-634
- ISSN
- 0109-5641 (ISSN-L)
- OpenAlex
- W3013448302
- Cited by
- 77
- References
- 44
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 16 · 2023: 17 · 2022: 12 · 2021: 11 · 2020: 2
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dental Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- guided bone regeneration, freeze-drying, in vitro degradation, tensile strength, osteogenic differentiation, cell proliferation, biocompatibility, bone regeneration
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Biocompatible Materials, Bone Regeneration, Caproates, Lactones, Osteogenesis, Polyesters, Tissue Engineering
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