Cited by 328Wound Healing and TreatmentsLiver physiology and pathologyDermatologic Treatments and Research

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The role of myofibroblasts in wound healing

Hinz, B.·2016·Current Research in Translational Medicine

DOI 10.1016/j.retram.2016.09.003

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Abstract

The importance of proper skin wound healing becomes evident when our body's repair mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair (fibrosis). Chronic wounds are a tremendous burden for patients and global healthcare systems and are on the rise due to their increasing incidence with age and diabetes. Curiously, these same risk factors also sign responsible for the development of hypertrophic scarring and organ fibrosis. Activated repair cells - myofibroblasts - are the main producers and organizers of extracellular matrix which is needed to restore tissue integrity after injury. Too many myofibroblasts working for too long cause tissue contractures that ultimately obstruct organ function. Insufficient myofibroblast activation and activities, in turn, prevents normal wound healing. This short review puts a spotlight on the myofibroblast for those who seek therapeutic targets in the context of dysregulated tissue repair. "Keep your myofibroblasts in balance" is the message.

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Authors: Hinz, B.
Affiliations: University of Toronto (CA)
Corresponding author: Hinz, B.
ORCID: Hinz, B.
Venue: Current Research in Translational Medicine
Publisher: Elsevier BV
Published: 2016-10
Volume: 64
Issue: 4
Pages: 171-177
ISSN: 2452-3186 (ISSN-L)
DOI: 10.1016/j.retram.2016.09.003
OpenAlex: W2548247411
Semantic Scholar: e7bcd03bb8cee915b9f4370cb05d16dc21405b08
Cited by: 328
References: 161
Citations by year: 2026: 26 · 2025: 35 · 2024: 38 · 2023: 46 · 2022: 38 · 2021: 53 · 2020: 34 · 2019: 28 · 2018: 22 · 2017: 8
FWCI: 20.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Research in Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
National Institute on Aging
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords: myofibroblasts, wound healing, chronic wounds, fibrosis, hypertrophic scars, extracellular matrix, tissue repair, myofibroblast activation, diabetes mellitus, therapeutic target
MeSH terms: Animals, Cicatrix, Contracture, Extracellular Matrix, Fibrosis, Granulation Tissue, Humans, Wound Healing, Apoptosis, Intercellular Signaling Peptides and Proteins, Myofibroblasts

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