Cited by 328Wound Healing and TreatmentsLiver physiology and pathologyDermatologic Treatments and Research

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The role of myofibroblasts in wound healing

Hinz, B.·2016·Current Research in Translational Medicine

DOI 10.1016/j.retram.2016.09.003

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Abstract

The importance of proper skin wound healing becomes evident when our body's repair mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair (fibrosis). Chronic wounds are a tremendous burden for patients and global healthcare systems and are on the rise due to their increasing incidence with age and diabetes. Curiously, these same risk factors also sign responsible for the development of hypertrophic scarring and organ fibrosis. Activated repair cells - myofibroblasts - are the main producers and organizers of extracellular matrix which is needed to restore tissue integrity after injury. Too many myofibroblasts working for too long cause tissue contractures that ultimately obstruct organ function. Insufficient myofibroblast activation and activities, in turn, prevents normal wound healing. This short review puts a spotlight on the myofibroblast for those who seek therapeutic targets in the context of dysregulated tissue repair. "Keep your myofibroblasts in balance" is the message.

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Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
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Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
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Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
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Richeldi, L., du Bois, R. M., Raghu, G., Azuma, A., Brown, K. K., Costabel, U., Cottin, V., Flaherty, K. R., Hansell, D. M., Inoue, Y., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402584 · Cited by 4,654
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
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WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629
PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
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Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
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Massagué, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3434 · Cited by 3,239
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985

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Knight, K. M., King, G. E., Palcsey, S. L., Suda, A., Liang, R., & Moalli, P. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.05.051 · Cited by 46
Allogeneic platelet‐rich plasma (PRP) is superior to platelets or plasma alone in stimulating fibroblast proliferation and migration, angiogenesis, and chemotaxis as relevant processes for wound healing
van der Bijl, I., Vlig, M., Middelkoop, E., & de Korte, D. (2019) · Transfusion · doi:10.1111/trf.15535 · Cited by 44
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Hoerst, K., van den Broek, L., Sachse, C., Klein, O., von Fritschen, U., Gibbs, S., & Hedtrich, S. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01772-2 · Cited by 41
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Men, S., Huo, Q., Shi, L., Yan, Y., Yang, C., Yu, W. H., & Liu, B. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13042 · Cited by 41
CD44 inhibits α-SMA gene expression via a novel G-actin/MRTF-mediated pathway that intersects with TGFβR/p38MAPK signaling in murine skin fibroblasts
Wang, Y., Mack, J. A., & Maytin, E. V. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007834 · Cited by 41
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Gelatin–chitosan–cellulose nanocrystals as an acellular scaffold for wound healing application: fabrication, characterisation and cytocompatibility towards primary human skin cells
Cheah, Y. J., Yunus, M. H. M., Fauzi, M. B., Tabata, Y., Hiraoka, Y., Phang, S. J., Chia, M. R., Buyong, M. R., & Yazid, M. D. (2023) · Cellulose · doi:10.1007/s10570-023-05212-w · Cited by 38
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Fibrosis in burns: an overview of mechanisms and therapies
Faour, S., Farahat, M., Aijaz, A., & Jeschke, M. G. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00254.2023 · Cited by 40
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Authors: Hinz, B.
Affiliations: University of Toronto (CA)
Corresponding author: Hinz, B.
ORCID: Hinz, B.
Venue: Current Research in Translational Medicine
Publisher: Elsevier BV
Published: 2016-10
Volume: 64
Issue: 4
Pages: 171-177
ISSN: 2452-3186 (ISSN-L)
DOI: 10.1016/j.retram.2016.09.003
OpenAlex: W2548247411
Semantic Scholar: e7bcd03bb8cee915b9f4370cb05d16dc21405b08
Cited by: 328
References: 161
Citations by year: 2026: 26 · 2025: 35 · 2024: 38 · 2023: 46 · 2022: 38 · 2021: 53 · 2020: 34 · 2019: 28 · 2018: 22 · 2017: 8
FWCI: 20.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Research in Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
National Institute on Aging
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords: myofibroblasts, wound healing, chronic wounds, fibrosis, hypertrophic scars, extracellular matrix, tissue repair, myofibroblast activation, diabetes mellitus, therapeutic target
MeSH terms: Animals, Cicatrix, Contracture, Extracellular Matrix, Fibrosis, Granulation Tissue, Humans, Wound Healing, Apoptosis, Intercellular Signaling Peptides and Proteins, Myofibroblasts

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The role of myofibroblasts in wound healing

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