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Cited by 219Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

Epidemiology of candidaemia and invasive candidiasis. A changing face

Quindós, Guillermo·2014·Revista Iberoamericana de Micología
DOI 10.1016/j.riam.2013.10.001
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Abstract

Invasive candidiasis is a leading cause of mortality. Candidaemia is the most common clinical presentation of invasive candidiasis but more that 30% of these infections do not yield positive blood cultures. Candida albicans remains the predominant aetiology, accounting for 50% of all cases. However, there has been an epidemiological shift in the last decades. Some species of Candida different to C. albicans have emerged as an important cause of severe candidaemia as they can exhibit resistance to fluconazole and other antifungal agents. Moreover, there is a different distribution of non C. albicans Candida species in relationship to patients' and hospital characteristics. Thus, Candida parapsilosis has been associated to candidaemia in neonates and young adults. This species usually has an exogenously origin and contaminates medical devices, causing central venous catheter-associated candidaemias. Candida glabrata, Candida tropicalis and Candida krusei are isolated in blood cultures from older patients (>65 years) with important risk factors, such as major abdominal surgery, solid tumours and haematologic malignancies, transplants, and/or prolonged treatment with corticoids. Moreover, important geographical differences in the distribution of the Candida species different to C. albicans causing invasive candidiasis have been reported: C. parapsilosis predominates in Australia, Latin America and Mediterranean countries of Africa, Asia and Europe. In contrast, C. glabrata has an important aetiological role in USA and Central and Northern Europe. Finally, an important and worrying issue is that mortality due to invasive candidiasis remains unacceptably high. This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012).

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Crossref · 10.1016/j.riam.2013.10.001

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Metadata

Authors
Quindós, G.
Affiliations
University of the Basque Country (ES)
Corresponding author
Quindós, Guillermo
ORCID
Quindós, Guillermo
Venue
Revista Iberoamericana de Micología
Publisher
Elsevier BV
Published
2014-01
Volume
31
Issue
1
Pages
42-48
ISSN
1130-1406 (ISSN-L)
DOI
10.1016/j.riam.2013.10.001
OpenAlex
W1993370685
Cited by
219
References
68
Citations by year
2026: 8 · 2025: 14 · 2024: 12 · 2023: 9 · 2022: 20 · 2021: 19 · 2020: 17 · 2019: 16 · 2018: 28 · 2017: 22 · 2016: 20 · 2015: 24 · 2014: 10
FWCI
2.28
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Revista Iberoamericana de Micología (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
  • Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords
invasive candidiasis, candidemia, non-albicans Candida, Candida albicans, Candida parapsilosis, Candida glabrata, Candida tropicalis, Candida krusei, fluconazole resistance, antifungal resistance, risk factors
MeSH terms
Adult, Candida, Child, Cross Infection, Female, Humans, Infant, Infant, Newborn, Male, Morbidity, Species Specificity, Global Health, Incidence, Age Distribution, Sex Distribution, Young Adult, Candidiasis, Invasive, Candidemia

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