Volatile organic compounds associated with diagnosis and disease characteristics in asthma – A systematic review
Open accessAbstract
Background Metabolomics refers to study of the metabolome, the entire set of metabolites produced by a biological system. The application of metabolomics to exhaled breath samples - breathomics - is a rapidly growing field with potential application to asthma diagnosis and management.Objectives We aimed to review the adult asthma breathomic literature and present a comprehensive list of volatile organic compounds identified by asthma breathomic models.Methods We undertook a systematic search for literature on exhaled volatile organic compounds in adult asthma. We assessed the quality of studies and performed a qualitative synthesis.Results We identified twenty studies; these were methodologically heterogenous with a variable risk of bias. Studies almost universally reported breathomics to be capable of differentiating - with moderate or greater accuracy - between samples from healthy controls and those with asthma; and to be capable of phenotyping disease. However, there was little concordance in the compounds upon which discriminatory models were based.Conclusion Results to-date are promising but validation in independent prospective cohorts is needed. This may be challenging given the high levels of inter-individual variation. However, large-scale, multi-centre studies are underway and validation efforts have been aided by the publication of technical standards likely to increase inter-study comparability. Successful validation of breathomic models for diagnosis and phenotyping would constitute an important step towards personalised medicine in asthma.
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Changes in the levels of certain VOCs, such as ethane and pentane, have been associated with asthma.
“Changes in the levels of certain VOCs, such as ethane and pentane, have been associated with asthma (Peel et al. 2020).”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Peel et al. 2020
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- Authors
- Peel, A. M., Wilkinson, M., Sinha, A., Loke, Y. K., Fowler, S. J., & Wilson, A. M.
- Affiliations
- University of East Anglia (GB)
- Manchester Academic Health Science Centre (GB)
- Corresponding author
- Peel, Adam M.
- Venue
- Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 169
- Pages
- 105984
- ISSN
- 0954-6111 (ISSN-L)
- OpenAlex
- W3025271774
- Cited by
- 40
- References
- 100
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Asthma UK Centre for Applied Research
- University of East Anglia
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- asthma, exhaled breath, volatile organic compounds, breathomics, metabolomics, asthma diagnosis, asthma phenotyping, biomarkers, personalized medicine, interindividual variability
- MeSH terms
- Asthma, Breath Tests, Female, Humans, Male, Severity of Illness Index, Biomarkers, Volatile Organic Compounds
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