Soluble guanylate cyclase

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

Arnold, W. P., Mittal, C. K., Katsuki, S., & Murad, F. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3203 · Cited by 1,459

Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS

Tesmer, J. J. G., Sunahara, R. K., Gilman, A. G., & Sprang, S. R. (1997) · Science · doi:10.1126/science.278.5345.1907 · Cited by 792

A molecular basis for nitric oxide sensing by soluble guanylate cyclase

Zhao, Y., Brandish, P. E., Ballou, D. P., & Marletta, M. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14753 · Cited by 323

Myoglobin discriminates between O2, NO, and CO by electrostatic interactions with the bound ligand

Olson, J. S., & Phillips, G. N. (1997) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s007750050169 · Cited by 288

Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases

Pellicena, P., Karow, D. S., Boon, E. M., Marletta, M. A., & Kuriyan, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405188101 · Cited by 271

NO activation of guanylyl cyclase

Russwurm, M., & Koesling, D. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600422 · Cited by 222

A molecular basis for NO selectivity in soluble guanylate cyclase

Boon, E. M., Huang, S. H., & Marletta, M. A. (2005) · Nature Chemical Biology · doi:10.1038/nchembio704 · Cited by 188

Spectroscopic Characterization of the Soluble Guanylate Cyclase-like Heme Domains from Vibrio cholerae and Thermoanaerobacter tengcongensis

Karow, D. S., Pan, D., Tran, R., Pellicena, P., Presley, A. D., Mathies, R. A., & Marletta, M. A. (2004) · Biochemistry · doi:10.1021/bi049374l · Cited by 184

Femtomolar Sensitivity of a NO Sensor from Clostridium botulinum

Nioche, P., Berka, V., Vipond, J., Minton, N., Tsai, A., & Raman, C. (2004) · Science · doi:10.1126/science.1103596 · Cited by 179

Unprecedented proximal binding of nitric oxide to heme: implications for guanylate cyclase

Lawson, D. M., Stevenson, C. E. M., Andrew, C. R., & Eady, R. R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5661 · Cited by 168

A Computational Tool for Monte Carlo Simulations of Biomolecular Reaction Networks Modeled on Physical Principles

Li, I. T. S., Mills, E., & Truong, K. (2009) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2009.2035114 · Cited by 2

NMR Studies of the Dynamics of High-Spin Nitrophorins: Comparative Studies of NP4 and NP2 at Close to Physiological pH

Berry, R. E., Dhanasekaran, M., Yang, F., & Walker, F. A. (2014) · Biochemistry · doi:10.1021/bi501305a · Cited by 2

Entry of water into the distal heme pocket of soluble guanylate cyclase β1 H-NOX domain alters the ligated CO structure: a resonance Raman and in silico simulation study

Xu, H., Zhang, Y., Chen, L., Li, Y., Li, C., Liu, L., Ogura, T., Kitagawa, T., & Li, Z. (2016) · RSC Advances · doi:10.1039/c6ra06515e · Cited by 2

Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1

Isenberg, J. S., Frazier, W. A., & Roberts, D. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00012-5 · Cited by 1

Modulation of Cellular Respiration by Endogenously Produced Nitric Oxide in Rat Hippocampal Slices

Ledo, A., Barbosa, R. M., & Laranjinha, J. A. N. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7831-1_5 · Cited by 1

Molecular targets in the search for endothelium-protecting compounds

Glushko, A. A., Voronkov, A. V., & Chernikov, M. V. (2014) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162014050069 · Cited by 1

Role of Oxidative Stress in Erectile Dysfunction After Prostate Cancer Therapy

Robinson, T. J., & Koontz, B. F. (2016) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-30705-3_21 · Cited by 1

Fluorimetric and mass-spectrometric methods for analysis of GTP-converting signal-transducing proteins and enzymes

Spangler, C. (2010) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.16753 · Cited by 1

Molecular model of soluble guanylyl cyclase: Insight into allostery in nitric oxide signaling

Fritz, B. G. (2011) · UA Campus Repository (The University of Arizona) · Cited by 1

Second Messengers in Cellular Signaling

DiPilato, L. M., & Zhang, J. (2008) · Wiley eBooks · doi:10.1002/9780470048672.wecb693

Influence of oxygen on vascular tone during acute hypoxia

Dada, J. (2013) · ORCA Online Research @Cardiff (Cardiff University)

Transcriptional Regulation of Soluble Guanylyl Cyclase

Hampton, A. (2009) · Arrow - TU Dublin (Technological University Dublin) · doi:10.21427/d7bg7s

Microbial Sensor Systems for Dihydrogen, Nitric Oxide, and Carbon Monoxide

Cramm, R., & Friedrich, B. (2009) · doi:10.1002/9783527629237.ch17

Membrane Protein Complexes Involved in Thrombospondin-1 Regulation of Nitric Oxide Signaling

Green, T. (2013) · UA Campus Repository (The University of Arizona)

α1-acid glycoprotein modulates the function of human neutrophils and platelets

Gunnarsson, P. (2009) · DiVA (Linkoping University)

and local warming in humans cutaneous vasodilation during whole body heat stress Antagonism of soluble guanylyl cyclase attenuates

Kellogg, D. L., Zhao, J. L., Wu, Y., Johnson, J. M., Wong, B. J., Fieger, S. M., Smith, C. J. W., Kenney, W. L., & Alexander, L. M. (2015)

Effects of Interleukin-17 on Endothelial Nitric Oxide Synthase and Transplant Arteriosclerosis

Liu, C.-Y. (2014) · Summit (Simon Fraser University)

Investigation of the distribution of nitrite and nitrate and nitrite reductase activity in models of cardiovascular disease

Ghosh, S. M. (2014)

Soluble Guanylyl Cyclase and Its Evolutionary Relatives

Sousa, E. H. S., Gonzalez, G., & Gilles‐Gonzalez, M. (2008) · Elsevier eBooks · doi:10.1016/b978-044452839-1.50020-6

Overview of Gas-sensing Systems

Aono, S. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781788012836-00001

Additional file 2 of Inhibition of NOS1 promotes the interferon response of melanoma cells

Chen, X., Zou, Z., Wang, Q., Gao, W., Zeng, S., Ye, S., Xu, P., Huang, M., Li, K., Chen, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746389

Understanding nitrate assimilation by eukaryotic green microalgae

Rani, V. (2023) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.11799

Additional file 4 of Inhibition of NOS1 promotes the interferon response of melanoma cells

Chen, X., Zou, Z., Wang, Q., Gao, W., Zeng, S., Ye, S., Xu, P., Huang, M., Li, K., Chen, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746395

Additional file 1 of Inhibition of NOS1 promotes the interferon response of melanoma cells

Chen, X., Zou, Z., Wang, Q., Gao, W., Zeng, S., Ye, S., Xu, P., Huang, M., Li, K., Chen, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746386

Additional file 3 of Inhibition of NOS1 promotes the interferon response of melanoma cells

Chen, X., Zou, Z., Wang, Q., Gao, W., Zeng, S., Ye, S., Xu, P., Huang, M., Li, K., Chen, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746392

Integrated analysis and validation of metabolism-related genes in lung transplantation-induced cold ischemia/ reperfusion injury

Zhu, L., Ding, J., Wei, D., & Chen, J. (2026) · PeerJ · doi:10.7717/peerj.20857

Rôle physiopathologique de la signalisation calcique dépendante de la protéine SERCA3 au niveau vasculaire.

Toth, M. (2025) · doi:10.70675/786d2b7az4817z4b0cz86daz6e8c7cdb8a90

Soluble guanylyl cyclase maturation in cells depends on reduction of the incoming heme by a cysteine in the enzyme’s beta subunit

Dai, Y., Misra, S., & Stuehr, D. J. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113541

BindingDB Entry 50020539: The evolution of small molecule enzyme activators.

BindingDB (2024) · UC San Diego · doi:10.7270/q2b56q63

Development of a Novel Nitric Oxide Sensor Using Nitrophorin 4 on an Attenuated Total Reflectance Platform

Lemon, J. T. (2012) · UA Campus Repository (The University of Arizona)

Molecular steps in soluble guanylate cyclase activation

Boon, E. M., Cary, S. P., Huang, S. H., Winger, J. A., & Marletta, M. A. (2005) · BMC Pharmacology · doi:10.1186/1471-2210-5-s1-s1

A molecular basis for nitric oxide sensing by soluble guanylate cyclase

Zhao, Y., Brandish, P. E., Ballou, D. P., & Marletta, M. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14753 · Cited by 323

Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor

Montfort, W. R., Wales, J. A., & Weichsel, A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6693 · Cited by 144

On the activation of soluble guanylyl cyclase by nitric oxide

Bellamy, T. C., Wood, J., & Garthwaite, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012368499 · Cited by 141

Structure and Regulation of Soluble Guanylate Cyclase

Derbyshire, E. R., & Marletta, M. A. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-050410-100030 · Cited by 466