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A topologically diverse family of fluoride channels

Macdonald, Christian B, Stockbridge, Randy B·2017·Current Opinion in Structural Biology
DOI 10.1016/j.sbi.2017.04.003PMC PMC5612848
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  • The fluoride channel family encompasses a topologically diverse set of proteins that provide an unusual glimpse into evolutionary processes in membrane transport proteins.

    “The fluoride channel family encompasses a topologically diverse set of proteins that provide an unusual glimpse into evolutionary processes in membrane transport proteins(68) (Figure 5a).”

    From Membrane exporters of fluoride ion (2021) · cites this paper as [68]

  • Among bacterial Flucs, gene duplications have occurred on at least five occasions.

    “In addition to the dual topology homodimers, among bacterial Flucs, gene duplications have occurred on at least five occasions (68);”

    From Membrane exporters of fluoride ion (2021) · cites this paper as [68]

  • Fluc proteins can be encoded by single genes forming antiparallel homodimers, or by paired genes forming heterodimers of obligate inward- and outward-facing subunits.

    “Fluc proteins can be encoded by single genes, in which case a single protomer is inserted into the membrane in both inward and outward-facing conformations, assembling as an antiparallel homodimer, or they can be encoded by paired genes that express to form heterodimers of obligate inward- and outward-facing subunits84.”

    From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [84]

  • Typically, genes for heterodimeric Flucs are adjacent in genomes, and both genes are required for fluoride efflux activity.

    “Typically, the genes for the heterodimeric Flucs are adjacent to each other in genomes, and both genes are required for fluoride efflux activity84.”

    From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [84]

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Research works printed but not linked: 40

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Metadata

Authors
Macdonald, C. B., & Stockbridge, R. B.
Venue
Current Opinion in Structural Biology
Publisher
Elsevier BV
Published
2017-08
Volume
45
Pages
142-149
ISSN
0959-440X
DOI
10.1016/j.sbi.2017.04.003
PMC
PMC5612848
Cited by
21
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
National Institutes of Health (R00GM111767)

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