Clinical significance of sleep EEG abnormalities in chronic schizophrenia
Abstract
This study aimed to investigate the relationship between measures of clinical symptom severity and sleep EEG parameters in a relatively diagnostically homogeneous group of patients with schizophrenia. We obtained sleep EEG data in 15 drug-free inpatients who met DSM-IV-R criteria for schizophrenia, undifferentiated type, with 15 age- and sex-matched normal controls over two consecutive night polysomnographic recordings. Clinical symptoms were assessed by the Positive and Negative Symptom Scale (PANSS) and Hamilton Rating Scale for Depression. Characteristic features of sleep disturbance were seen in patients with schizophrenia: profound difficulties in sleep initiation and maintenance, poor sleep efficiency, a slow wave sleep (SWS) deficit, and an increased REM density. SWS was inversely correlated with cognitive symptoms. REM density was inversely correlated with positive, cognitive, and emotional discomfort symptoms as well as PANSS total score. Our data demonstrate that drug-free patients with chronic undifferentiated type schizophrenia suffer from profound disturbances in sleep continuity and sleep architecture. Both the SWS deficit and cognitive impairment found in schizophrenics in this study may relate to similar underlying structural brain abnormalities.
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An association between increased positive psychotic symptoms and reduced REM density has been reported.
“An association between increased positive psychotic symptoms and reduced REM density has also been reported (Rotenberg et al., 1997, Yang and Winkelman, 2006).”
From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Yang and Winkelman, 2006
Cites
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Impairment of visuospatial memory is associated with decreased slow wave sleep in schizophrenia
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Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055 · see citing works
Sleep and mental disorders: a meta-analysis of polysomnographic research
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“…oscillations and synchrony (Spencer et al., 2003; Cho et al., 2006; Minzenberg et al., 2010; Uhlhaas and Singer, 2010) and reductions in slow-wave sleep (Yang and Winkelman, 2006), and it has been hypothesized that these abnormalities play an important role in the pathophysiology of psychosis.”
BackgroundThalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles
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The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review
Reeve, S., Sheaves, B., & Freeman, D. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2015.09.001 · Cited by 273 · see citing works
“…naive patients (Lauer, Schreiber, Pollmächer, Holsboer, & Krieg, 1997; Poulin, Daoust, Forest, Stip, & Godbout, 2003; Tandon et al., 1992; Yang & Winkelman, 2006) although there are inconsistent results, mostly from studies with smaller sample sizes (Ganguli, 1987; Tandon, Shipley,…”
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Slow wave sleep deficits as a trait marker in patients with schizophrenia
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Maple, A. M., Rowe, R. K., Lifshitz, J., Fernandez, F., & Gallitano, A. L. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418803802 · Cited by 17 · see citing works
- Authors
- Yang, C., & Winkelman, J. W.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Winkelman, John W.
- ORCID
- Winkelman, John W.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 82
- Issue
- 2-3
- Pages
- 251-260
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2073797983
- Cited by
- 105
- References
- 4
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 12 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 5
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- schizophrenia, sleep EEG abnormalities
- MeSH terms
- Adult, Brain, Chronic Disease, Cognition Disorders, Electroencephalography, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Sleep, Sleep Wake Disorders, Sleep, REM, Statistics as Topic, Polysomnography
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