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Cited by 110Sleep and related disordersSchizophrenia research and treatmentCircadian rhythm and melatonin

Schizophrenia patients with predominantly positive symptoms have more disturbed sleep-wake cycles measured by actigraphy

Afonso, Pedro, Brissos, Sofia, Figueira, Maria Luísa, Paiva, Teresa·2011·Psychiatry Research
DOI 10.1016/j.psychres.2010.12.031
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Abstract

Sleep disturbances are widespread in schizophrenia, and one important concern is to determine the impact of this disruption on self-reported sleep quality and quality of life (QoL). Our aim was to evaluate the sleep-wake cycle in a sample of patients with schizophrenia (SZ), and whether sleep patterns differ between patients with predominantly negative versus predominantly positive symptoms, as well as its impact on sleep quality and QoL. Twenty-three SZ outpatients were studied with 24 h continuous wrist-actigraphy during 7 days. The quality of sleep was assessed with the Pittsburgh Sleep Quality Index (PSQI), and the self-reported QoL was evaluated with the World Health Organization Quality of Life - Abbreviated version (WHOQOL-Bref). About half of the studied population presented an irregular sleep-wake cycle. We found a trend for more disrupted sleep-wake patterns in patients with predominantly positive symptoms, who also had a trend self-reported worse quality of sleep and worse QoL in all domains. Overall, patients with worse self-reported QoL demonstrated worse sleep quality. Our findings suggest that SZ patients are frequently affected with sleep and circadian rhythm disruptions; these may have a negative impact on rehabilitation strategies. Moreover, poor sleep may play a role in sustaining poor quality of life in SZ patients.

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  • Sleep problems reduce quality of life (Kyle et al., 2010a, Kyle et al., 2010b), and sleep and quality of life have both been linked to psychotic symptoms in clinical groups (Afonso et al., 2011).

    “Sleep problems reduce quality of life (Kyle et al., 2010a, Kyle et al., 2010b), and sleep and quality of life have both been linked to psychotic symptoms in clinical groups (Afonso et al., 2011).”

    From Sleep duration and psychotic experiences in patients at risk of psychosis: a secondary analysis of the EDIE-2 trial (2019) · cites this paper as Afonso et al., 2011

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Authors
Afonso, P., Brissos, S., Figueira, M. L., & Paiva, T.
Affiliations
University of Lisbon (PT)
Corresponding author
Afonso, Pedro
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2011-08
Volume
189
Issue
1
Pages
62-66
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2010.12.031
OpenAlex
W2044900313
Cited by
110
References
47
Citations by year
2026: 4 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 10 · 2012: 4
FWCI
8.27
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • World Health Organization
  • Cilag
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
schizophrenia, sleep-wake cycle, sleep disorders, circadian rhythm disruption, positive symptoms, negative symptoms, sleep quality, quality of life, actigraphy, Pittsburgh Sleep Quality Index, WHOQOL-BREF
MeSH terms
Adult, Circadian Rhythm, Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Movement, Psychiatric Status Rating Scales, Reaction Time, Schizophrenia, Schizophrenic Psychology, Chi-Square Distribution, Actigraphy

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