Do sleep abnormalities and misaligned sleep/circadian rhythm patterns represent early clinical characteristics for developing psychosis in high risk populations?
Abstract
Sleep architecture changes, such as slow-wave sleep (SWS) percentage variations and reductions in latency and density of rapid eye movement (REM), are found in most patients with schizophrenia and are considered to be an important part of the pathophysiology of the disorder. In addition to these sleep parameters changes, disruptions in sleep homeostasis and the sleep/circadian rhythm also occur in these patients. Sleep/circadian rhythm abnormalities negatively affect neocortical plasticity and cognition and often precede the diagnosis of the illness. Thus, it has been suggested that the sleep/circadian rhythm might be involved in the pathophysiology of psychosis. Recent advances in the identification of individuals at a high risk for developing schizophrenia allow us to investigate several neurobiological processes involved in the development of psychosis. In this article, we review the current evidence of the effects of sleep parameter abnormalities, disruptions in sleep homeostasis and misalignments of sleep circadian rhythm on the early stages of schizophrenia. In addition, we discuss the preliminary evidence of sleep and circadian rhythm abnormalities during the prodromal stages of psychosis and propose that these abnormalities can be explored as potential predictors, as an adjunct to clinical diagnosis, of developing a psychotic disorder in at risk populations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There has been a lack of research specifically investigating the causal contribution of sleep disturbance to psychotic experiences in at-risk individuals.
“However there has been a surprising lack of research specifically investigating the causal contribution of sleep disturbance to psychotic experiences in at-risk individuals (Davies et al., 2016; Reeve et al., 2015; Zanini et al., 2013).”
From Sleep duration and psychotic experiences in patients at risk of psychosis: a secondary analysis of the EDIE-2 trial (2019) · cites this paper as Zanini et al., 2013
Cites
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370 · see citing works
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118 · see citing works
Two-Process Model of Sleep Regulation
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6166 · Cited by 3,895 · see citing works
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760 · see citing works
Regularly Occurring Periods of Eye Motility, and Concomitant Phenomena, During Sleep
Aserinsky, E., & Kleitman, N. (1953) · Science · doi:10.1126/science.118.3062.273 · Cited by 2,488 · see citing works
A Systematic Review of the Prevalence of Schizophrenia
Saha, S., Chant, D., Welham, J., & McGrath, J. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020141 · Cited by 2,168 · see citing works
Dement, W., & Kleitman, N. (1957) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(57)90088-3 · Cited by 1,876 · see citing works
The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review
Fusar-Poli, P., Borgwardt, S., Bechdolf, A., Addington, J., Riecher-Rössler, A., Schultze-Lutter, F., Keshavan, M., Wood, S., Ruhrmann, S., Seidman, L. J., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.269 · Cited by 1,483 · see citing works
Sleep and Psychiatric Disorders: A Meta-analysis
Benca, R. M. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080059010 · Cited by 1,468 · see citing works
Gradisar, M., Gardner, G., & Dohnt, H. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.11.008 · Cited by 1,196 · see citing works
The Prodromal Phase of First-episode Psychosis: Past and Current Conceptualizations
Yung, A. R., & McGorry, P. D. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.2.353 · Cited by 1,168 · see citing works
Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group
Yung, A. R., Phillips, L. J., Yuen, H. P., Francey, S. M., McFarlane, C. A., Hallgren, M., & McGorry, P. D. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00167-6 · Cited by 1,136 · see citing works
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055 · see citing works
Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features
Yung, A. R., Phillips, L., Yuen, H. P., & McGorry, P. D. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00192-0 · Cited by 753 · see citing works
Prediction of psychosis. A step towards indicated prevention of schizophrenia.
Yung, A. R., Phillips, L., McGorry, P. D., McFarlane, C. A., Francey, S. M., Harrigan, S., Patton, G. C., & Jackson, H. J. (1998) · PubMed · Cited by 698 · see citing works
Yung, A. R., Phillips, L., McGorry, P. D., McFarlane, C. A., Francey, S. M., Harrigan, S., Patton, G. C., & Jackson, H. J. (1998) · The British Journal of Psychiatry · doi:10.1192/s0007125000297602 · Cited by 636 · see citing works
Altered brain response to verbal learning following sleep deprivation
Drummond, S. P. A., Brown, G. G., Gillin, J. C., Stricker, J. L., Wong, E. C., & Buxton, R. B. (2000) · Nature · doi:10.1038/35001068 · Cited by 557 · see citing works
Changes in sleep cycle patterns with age
Feinberg, I. (1974) · Journal of Psychiatric Research · doi:10.1016/0022-3956(74)90011-9 · Cited by 557 · see citing works
The Initial Prodrome in Psychosis: Descriptive and Qualitative Aspects
Yung, A., & McGorry, P. (1996) · Australian and New Zealand journal of psychiatry (Print) · doi:10.3109/00048679609062654 · Cited by 504 · see citing works
Wamsley, E. J., Tucker, M. A., Shinn, A. K., Ono, K. E., McKinley, S. K., Ely, A. V., Goff, D. C., Stickgold, R., & Manoach, D. S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.008 · Cited by 492 · see citing works
Kauer‐Sant’Anna, M., Kapczinski, F. P., Andreazza, A. C., Bond, D. J., Lam, R. W. M., Young, L. T., & Yatham, L. N. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009310 · Cited by 434 · see citing works
Sleep Disturbances in Patients with Schizophrenia: Impact and Effect of Antipsychotics
Cohrs, S. (2008) · CNS Drugs · doi:10.2165/00023210-200822110-00004 · Cited by 433 · see citing works
Sleep and circadian rhythm disruption in schizophrenia
Wulff, K., Dijk, D.-J., Middleton, B., Foster, R. G., & Joyce, E. M. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.096321 · Cited by 426 · see citing works
Vita, A., Peri, L. M. D., Silenzi, C., & Dieci, M. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.11.004 · Cited by 397 · see citing works
The Human K-Complex Represents an Isolated Cortical Down-State
Cash, S. S., Halgren, E., Dehghani, N., Rossetti, A. O., Thesen, T., Wang, C., Devinsky, O., Kuzniecky, R., Doyle, W., Madsen, J. R., et al. (2009) · Science · doi:10.1126/science.1169626 · Cited by 394 · see citing works
Yung, A. R., Nelson, B., Stanford, C., Simmons, M. B., Cosgrave, E. M., Killackey, E., Phillips, L. J., Bechdolf, A., Buckby, J., & McGorry, P. D. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.07.012 · Cited by 358 · see citing works
Principles and Practice of Sleep Medicine
Westbrook, P. R. (1990) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62127-2 · Cited by 343 · see citing works
Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder
McDonald, C., Zanelli, J., Rabe‐Hesketh, S., Ellison-Wright, I., Sham, P. C., Kalidindi, S., Murray, R. M., & Kennedy, N. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.021 · Cited by 295 · see citing works
Sleep in Untreated Patients With Schizophrenia: A Meta-Analysis
Chouinard, S., Poulin, J., Stip, É., & Godbout, R. (2004) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007145 · Cited by 275 · see citing works
Sleep in schizophrenia patients and the effects of antipsychotic drugs.
Monti, J., & Monti, D. (2004) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(02)00158-2 · Cited by 229 · see citing works
Sleep–wake cycles and cognitive functioning in schizophrenia
Bromundt, V., Köster, M., Georgiev-Kill, A., Opwis, K., Wirz-Justice, A., Stoppe, G., & Cajochen, C. (2011) · British Journal of Psychiatry · doi:10.1192/bjp.bp.110.078022 · Cited by 223 · see citing works
Spatial working memory ability is a marker of risk-for-psychosis
Wood, S. J., Pantelis, C., Proffitt, T., Phillips, L., Stuart, G. W., Buchanan, J., Mahony, K. E., Brewer, W. J., Smith, D. J., & McGorry, P. D. (2003) · Psychological Medicine · doi:10.1017/s0033291703008067 · Cited by 219 · see citing works
Larson, M. K., Walker, E. F., & Compton, M. T. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.93 · Cited by 203 · see citing works
Correll, C. U., Hauser, M., Auther, A. M., & Cornblatt, B. A. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02235.x · Cited by 196 · see citing works
Tandon, R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820030017003 · Cited by 193 · see citing works
Sleep Disorders Medicine. Basic Science, Technical Considerations and Clinical Aspects.
Olejniczak, P. W. (1999) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199911000-00009 · Cited by 190 · see citing works
Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia
Balu, D. T., & Coyle, J. T. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.005 · Cited by 182 · see citing works
Sleep disturbance in schizophrenia
Monti, J., & Monti, D. (2005) · International Review of Psychiatry · doi:10.1080/09540260500104516 · Cited by 175 · see citing works
Poulin, J., Daoust, A.-M., Forest, G., Stip, E., & Godbout, R. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00346-8 · Cited by 160 · see citing works
Miller, T. J., Zipursky, R. B., Perkins, D., Addington, J., Woods, S. W., Hawkins, K. A., Hoffman, R., Preda, A., Epstein, I., Addington, D., et al. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00440-1 · Cited by 150 · see citing works
Randomized Controlled Trial of Interventions for Young People at Ultra High Risk for Psychosis
Yung, A. R., Phillips, L., Nelson, B., Francey, S. M., PanYuen, H., Simmons, M. B., Ross, M., Kelly, D., Baker, K., Amminger, G. P., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04979ora · Cited by 146 · see citing works
Plasticity of the Intrinsic Period of the Human Circadian Timing System
Scheer, F. A. J. L., Wright, K. P., Kronauer, R. E., & Czeisler, C. A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000721 · Cited by 146 · see citing works
The maximal capacity for sleep: rapid eye movement density as an index of sleep satiety.
Aserinsky, E. (1969) · PubMed · Cited by 145 · see citing works
Early Detection and Intervention for Initial Episodes of Schizophrenia
Falloon, I. R. H., Kydd, R. R., Coverdale, J., & Laidlaw, T. M. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.2.271 · Cited by 139 · see citing works
Frank, E., Swartz, H. A., & Boland, E. M. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.3/efrank · Cited by 129 · see citing works
Sleep in Schizophrenia: Impairments, Correlates, and Treatment
Benson, K. L. (2006) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2006.08.002 · Cited by 112 · see citing works
Clinical significance of sleep EEG abnormalities in chronic schizophrenia
Yang, C., & Winkelman, J. W. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.10.021 · Cited by 105 · see citing works
The WHO World Health Report 2001 on mental health
Saraceno, B. (2002) · Epidemiologia e Psichiatria Sociale · doi:10.1017/s1121189x00005546 · Cited by 104 · see citing works
Effects of clozapine on sleep: A longitudinal study
Hinze‐Selch, D., Mullington, J. M., Orth, A., Lauer, C. J., & Pollmächer, T. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00347-2 · Cited by 99 · see citing works
The lifetime trajectory of schizophrenia and the concept of neurodevelopment
Andreasen, N. C. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.3/nandreasen · Cited by 98 · see citing works
Olanzapine acute administration in schizophrenic patients increases delta sleep and sleep efficiency
Salín-Pascual, R. J., Herrera-Estrella, M., Galicia-Polo, L., & Laurrabaquio, M. R. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00372-2 · Cited by 94 · see citing works
Fusar‐Poli, P., Broome, M. R., Woolley, J. B., Johns, L., Tabraham, P., Bramon, E., Valmaggia, L., Williams, S., & McGuire, P. K. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.05.012 · Cited by 93 · see citing works
Amminger, G., Leicester, S., Yung, A., Phillips, L., Berger, G., Francey, S., Yuen, H. P., & Mcgorry, P. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.02.018 · Cited by 90 · see citing works
The PACE Clinic: Identification and Management of Young People at “Ultra” High Risk of Psychosis
Phillips, L., Leicester, S., O'Dwyer, L., Francey, S., Koutsogiannis, J., Abdel-Baki, A., Kelly, D., Jones, S., Vay, C., Yung, A., et al. (2002) · Journal of Psychiatric Practice · doi:10.1097/00131746-200209000-00002 · Cited by 83 · see citing works
First-episode psychosis in the military: A comparative study of prodromal symptoms
Tan, H.-Y., Ang, Y.-G., Tan, H.-Y., & Ang, Y.-G. (2001) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2001.00912.x · Cited by 80 · see citing works
Further observations on electrophysiological sleep patterns in schizophrenia
Feinberg, I., Koresko, R. L., & Gottlieb, F. (1965) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(65)80004-9 · Cited by 79 · see citing works
Wetter, T. C., Lauer, C. J., Gillich, G., & Pollmächer, T. (1996) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(96)00022-2 · Cited by 73 · see citing works
Maixner, S. M., Tandon, R., Eiser, A. S., Taylor, S. F., DeQuardo, J. R., & Shipley, J. E. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.11.1600 · Cited by 71 · see citing works
Effect of risperidone on sleep in schizophrenia: a comparison with haloperidol
Yamashita, H., Morinobu, S., Yamawaki, S., Horiguchi, J., & Nagao, M. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00009-4 · Cited by 69 · see citing works
Conus, P., Ward, J., Lucas, N., Cotton, S., Yung, A. R., Berk, M., & McGorry, P. D. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.12.021 · Cited by 68 · see citing works
Pukrop, R., & Klosterkötter, J. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9191-1 · Cited by 66 · see citing works
Comparing Genes and Phenomenology in the Major Psychoses: Schizophrenia and Bipolar 1 Disorder
Ivleva, E. I., Thaker, G. K., & Tamminga, C. A. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn051 · Cited by 66 · see citing works
Sleep correlates of cognition in early course psychotic disorders
Keshavan, M. S., Montrose, D. M., Miewald, J. M., & Jindal, R. D. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.05.027 · Cited by 62 · see citing works
Effect of neuroleptic treatment on polysomnographic measures in schizophrenia
Taylor, S. F., Tandon, R., Shipley, J. E., & Eiser, A. S. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90004-6 · Cited by 61 · see citing works
Lee, J. H., Woo, J. I., & Meltzer, H. Y. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00284-0 · Cited by 58 · see citing works
O sono em transtornos psiquiátricos
Lucchesi, L. M., Pradella-Hallinan, M. L. D. C., Lucchesi, M., & Moraes, W. A. D. S. (2005) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462005000500006 · Cited by 57 · see citing works
Jung, W. H., Jang, J. H., Byun, M. S., An, S. K., & Kwon, J. S. (2010) · Journal of Korean Medical Science · doi:10.3346/jkms.2010.25.12.1700 · Cited by 57 · see citing works
Young people at ultra high risk for psychosis: a research update
Yung, A. R., & Nelson, B. (2011) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2010.00241.x · Cited by 56 · see citing works
Fusar‐Poli, P., Broome, M. R., Matthíasson, P., Woolley, J. B., Mechelli, A., Johns, L., Tabraham, P., Bramon, E., Valmaggia, L., Williams, S., et al. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp074 · Cited by 56 · see citing works
Mansur, R. B., Zugman, A., Asevedo, E. D. M., da Cunha, G. R., Bressan, R. A., & Brietzke, E. M. (2012) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2012.02354.x · Cited by 55 · see citing works
Self-citationYamashita, H., Mori, K., Nagao, M., Okamoto, Y., Morinobu, S., & Yamawaki, S. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n1114 · Cited by 46 · see citing works
Chokroverty, S. (2017) · Springer: New York · doi:10.1007/978-1-4939-6578-6 · Cited by 45 · see citing works
Effect of Prolonged Chlorpromazine Administration on the Sleep of Chronic Schizophrenics
Kaplan, J. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760130044007 · Cited by 43 · see citing works
Bell, R. C., Farmer, S., Ries, R. K., & Srebnik, D. S. (2009) · Psychiatric Services · doi:10.1176/ps.2009.60.12.1686 · Cited by 42 · see citing works
Coping with symptoms of relapse in schizophrenia
Kumar, S., THARA, R., & Rajkumar, S. (1989) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf01739656 · Cited by 39 · see citing works
Zhang, Z.-J., Chen, Y.-C., Wang, H.-N., Wang, H.-H., Xue, Y.-Y., Feng, S.-F., & Tan, Q.-R. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.01.037 · Cited by 39 · see citing works
Poulin, J., Chouinard, S., Pampoulova, T., Lecomte, Y., Stip, É., & Godbout, R. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.08.009 · Cited by 38 · see citing works
Early intervention in psychosis: a map of clinical and research initiatives in Latin America
Brietzke, E. M., Gadelha, A., Dias, Á. M., Mansur, R. B., & Bressan, R. A. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000600007 · Cited by 35 · see citing works
Self-citationMurray, G., Michalak, E. E., LEVITT, A. J., Levitan, R. D., Enns, M. W., Morehouse, R. L., & Lam, R. W. M. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.10.010 · Cited by 29 · see citing works
Sleep-related cognitive function and the K-complex in schizophrenia
Ramakrishnan, M., Sartory, G., van Beekum, A., Lohrmann, T., & Pietrowsky, R. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.06.019 · Cited by 23 · see citing works
Sleep in Psychiatric Disorders
Franzen, P. L., & Buysse, D. J. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_46 · Cited by 23 · see citing works
Primary Prevention in Psychiatry Adult Populations
Brenner, R., Madhusoodanan, S., Puttichanda, S., & Chandra, P. (2010) · Annals of Clinical Psychiatry · doi:10.1177/104012371002200403 · Cited by 21 · see citing works
Schizophrenic delusions: the detection of warning signals
Jørgensen, P. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00033-4 · Cited by 19 · see citing works
Stable deficits in gray matter volumes following a first episode of schizophrenia
Zipursky, R. B., Christensen, B. K., & Mikulis, D. J. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.02.028 · Cited by 14 · see citing works
Kraepelin's anxious or depressive mania: a case report
Cheniaux, E. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000200021 · Cited by 4 · see citing works
Spontaneous improvement in severe, chronic schizophrenia and its neuropsychological correlates
Murray, G. K., Leeson, V. C., & McKenna, P. J. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.4.357 · Cited by 3 · see citing works
A study using gadopenetetate dimeglumine enhanced MRI scans in schizophrenia
Szymanski, S., Lieberman, J. M., Zito, J. L., Ashtari, M., & Degreef, G. (1989) · Schizophrenia Research · doi:10.1016/0920-9964(89)90167-9 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 88 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review
Reeve, S., Sheaves, B., & Freeman, D. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2015.09.001 · Cited by 273 · see citing works
“…schizophrenia (Benson, 2006, 2008; Cohrs, 2008; Lunsford-Avery & Mittal, 2013; Monti & Monti, 2004; Pritchett et al., 2012; Waters & Manoach, 2012; Zanini et al., 2013), this article will particularly focus on research that investigates the association of sleep dysfunction with individual…”
BackgroundSchizophrenia and sleep disorders: links, risks, and management challenges
Kaskie, R. E., Graziano, B., & Ferrarelli, F. (2017) · Nature and Science of Sleep · doi:10.2147/nss.s121076 · Cited by 201 · see citing works
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder
Bunney, B. G., Li, J. Z., Walsh, D. M. A., Stein, R., Vawter, M. P., Cartagena, P. M., Barchas, J. D., Schatzberg, A. F., Myers, R., Watson, S. J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.138 · Cited by 185 · see citing works
The relationship between sleep and postpartum mental disorders: A systematic review
Lawson, A., Murphy, K. E., Sloan, E. P., Uleryk, E. M., & Dalfen, A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.017 · Cited by 160 · see citing works
A systematic review of the nature and correlates of sleep disturbance in early psychosis
Davies, G., Haddock, G., Yung, A. R., Mulligan, L. D., & Kyle, S. D. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.01.001 · Cited by 154 · see citing works
McCarthy, M. J., Gottlieb, J. F., Gonzalez, R., McClung, C. A., Alloy, L. B., Cain, S., Dulcis, D., Etain, B., Frey, B. N., Garbazza, C., et al. (2022) · Bipolar Disorders · doi:10.1111/bdi.13165 · Cited by 136 · see citing works
Lederman, O., Ward, P. B., Firth, J., Maloney, C., Carney, R., Vancampfort, D., Stubbs, B., Kalucy, M., & Rosenbaum, S. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.11.004 · Cited by 128 · see citing works
Sleep disturbances in schizophrenia spectrum and bipolar disorders – a transdiagnostic perspective
Laskemoen, J. F., Simonsen, C., Büchmann, C. B., Barrett, E. A., Bjella, T. D., Lagerberg, T. V., Vedal, T. S. J., Andreassen, O. A., Melle, I. S., & Aas, M. (2019) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2019.02.006 · Cited by 98 · see citing works
Lunsford-Avery, J. R., Gonçalves, B. D. S. B., Brietzke, E., Bressan, R. A., Gadelha, A., Auerbach, R. P., & Mittal, V. A. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.01.051 · Cited by 89 · see citing works
Self-citationSleep and circadian alterations in people at risk for bipolar disorder: A systematic review
Melo, M. C. A., Garcia, R. F., Neto, V. B. L., Sá, M. B., de Mesquita, L. M. F., de Araújo, C. F. C., & de Bruin, V. M. S. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.005 · Cited by 82 · see citing works
Sleep Disorders Among People With Schizophrenia: Emerging Research
Klingaman, E. A., Palmer-Bacon, J., Bennett, M. E., & Rowland, L. M. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0616-7 · Cited by 74 · see citing works
Winsky‐Sommerer, R., de Oliveira, P., Loomis, S., Wafford, K. A., Dijk, D., & Gilmour, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.027 · Cited by 66 · see citing works
Castelnovo, A., Graziano, B., Ferrarelli, F., & D’Agostino, A. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13815 · Cited by 64 · see citing works
Abnormalities in sleep patterns in individuals at risk for psychosis and bipolar disorder
Zanini, M. A., Castro, J., Cunha, G. R., Asevedo, E., Pan, P. M., Bittencourt, L., Coelho, F. M., Tufik, S., Gadelha, A., Bressan, R. A., et al. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.08.023 · Cited by 64 · see citing works
Self-citationSleep, circadian rhythms, and schizophrenia
Cosgrave, J., Wulff, K., & Gehrman, P. (2018) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000419 · Cited by 60 · see citing works
Hwang, D.-K., Nam, M., & Lee, Y.-J. G. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.02.002 · Cited by 48 · see citing works
Sleep disturbances and the At Risk Mental State: A systematic review and meta-analysis
Clarke, L., Chisholm, K., Cappuccio, F. P., Tang, N. K. Y., Miller, M. A., Elahi, F., & Thompson, A. D. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.06.027 · Cited by 48 · see citing works
Sleep therapeutics and neuropsychiatric illness
Krystal, A. D. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0474-9 · Cited by 43 · see citing works
Kılıçaslan, E. E., Esen, A. T., Kasal, M. I., Ozelci, E., Boysan, M., & Güleç, M. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.08.081 · Cited by 41 · see citing works
Reeve, S., Nickless, A., Sheaves, B., Hodgekins, J., Stewart, S. L. K., Gumley, A., Fowler, D., Morrison, A., & Freeman, D. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2018.08.006 · Cited by 39 · see citing works
Are Circadian Disturbances a Core Pathophysiological Component of Schizophrenia?
Delorme, T. C., Srivastava, L. K., & Cermakian, N. (2020) · Journal of Biological Rhythms · doi:10.1177/0748730420929448 · Cited by 38 · see citing works
Psychosis as an Evolutionary Adaptive Mechanism to Changing Environments
Scheepers, F. E., de Mul, J., Boer, F., & Hoogendijk, W. J. G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00237 · Cited by 29 · see citing works
The interaction between subclinical psychotic experiences, insomnia and objective measures of sleep
Cosgrave, J., Haines, R., der Kloet, D. V. H., Purple, R. J., Porcheret, K., Foster, F., & Wulff, K. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.06.058 · Cited by 29 · see citing works
Lunsford‐Avery, J. R., Dean, D. J., & Mittal, V. A. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.025 · Cited by 29 · see citing works
Bowman, S., McKinstry, C., Howie, L., & McGorry, P. D. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.12928 · Cited by 23 · see citing works
Community Psychosis Risk Screening: An Instrument Development Investigation
Ellman, L. M., Schiffman, J. E., & Mittal, V. A. (2020) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20200019 · Cited by 23 · see citing works
Wang, Q., Hu, S., Qi, L., Wang, X., Jin, G., Wu, D., Wang, Y., & Ren, L. (2023) · Behavioral and Brain Functions · doi:10.1186/s12993-023-00220-z · Cited by 22 · see citing works
Fekih-Romdhane, F., Hallit, S., Cheour, M., & Jahrami, H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1011963 · Cited by 23 · see citing works
Schizophrenia: from neurophysiological abnormalities to clinical symptoms
Castelnovo, A., Ferrarelli, F., & D’Agostino, A. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00478 · Cited by 21 · see citing works
Assimakopoulos, K., Karaivazoglou, K., Σκώκου, Μ., Kalogeropoulou, M., Kolios, P., Gourzis, P., Patrinos, G. P., & Tsermpini, E. E. (2018) · Medicines · doi:10.3390/medicines5020027 · Cited by 19 · see citing works
Czekus, C., Steullet, P., López, A. O., Bozic, I., Rusterholz, T., Bandarabadi, M., Kim, Q., & Herrera, C. G. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01700-w · Cited by 17 · see citing works
Fekih‐Romdhane, F., Nefzi, H., Sassi, H., Cherif, W., & Cheour, M. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.13058 · Cited by 17 · see citing works
Sleep disturbances in youth at‐risk for serious mental illness
Stowkowy, J., Brummitt, K., Bonneville, D., Goldstein, B. I., Wang, J., Kennedy, S. H., Bray, S., Lebel, C. A., MacQUEEN, G. M., & Addington, J. (2019) · Early Intervention in Psychiatry · doi:10.1111/eip.12898 · Cited by 16 · see citing works
From macro to micro: slow-wave sleep and its pivotal health implications
Ishii, T., Taweesedt, P. T., Chick, C. F., O'Hara, R. M., & Kawai, M. (2024) · Frontiers in Sleep · doi:10.3389/frsle.2024.1322995 · Cited by 13 · see citing works
Linguistic and Non-Linguistic Markers of Disorganization in Psychotic Illness
Liebenthal, E., Ennis, M. M., Rahimi-Eichi, H., Lin, E. C., Chung, Y., & Baker, J. T. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.12.003 · Cited by 16 · see citing works
Jia, N., Zhu, Z., Liu, Y., Yin, X., Man, L., Hou, W., Zhang, H., Yu, Q., & Hui, L. (2024) · SLEEP · doi:10.1093/sleep/zsae209 · Cited by 11 · see citing works
The impact of assertive outreach teams on hospital admissions for psychosis: a time series analysis
Hamilton, I., Lloyd, C., Bland, M., & Grainge, A. S. (2015) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/jpm.12239 · Cited by 10 · see citing works
Marin, L., Guàrdia, A., González-Rodríguez, A., Haba‐Rubio, J., Natividad, M., Bosch, E., Domínguez, N. P., & Monreal, J. A. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5020020 · Cited by 11 · see citing works
Clozapine-induced esophagitis at therapeutic dose: a case report
Javelot, H., Michel, B., Kumar, D., & Audibert, B. (2016) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2015-1787 · Cited by 9 · see citing works
The examination of sleep hygiene, quality of life, and schizotypy in young adults
O’Kane, T. W., Sledjeski, E. M., & Dinzeo, T. J. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.016 · Cited by 7 · see citing works
Shah, J. L., Chakravarty, M. M., Joober, R., & Lepage, M. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160053 · Cited by 7 · see citing works
What Can Happen When Postpartum Anxiety Progresses to Psychosis? A Case Study
Pirec, V. (2018) · Case Reports in Psychiatry · doi:10.1155/2018/8262043 · Cited by 6 · see citing works
Ristanovic, I., Haase, C. M., Lunsford‐Avery, J. R., & Mittal, V. A. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.02.038 · Cited by 7 · see citing works
GALYNKER, I. I., Yaseen, Z. S., Koppolu, S. S., Vaughan, B., Szklarska-Imiolek, M., Cohen, L. J., Salvanti, T. M., & Kim, H.-J. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0808-7 · Cited by 6 · see citing works
The Impact of Sleep on Neurocognition and Functioning in Schizophrenia—Is It Time to Wake-Up?
Kimhy, D., Ospina, L. H., Beck-Felts, K., Fakhoury, A., Mullins, A. E., & Varga, A. W. (2022) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20220001 · Cited by 5 · see citing works
Cioffi, L., Wein, P. Y., Miller, S. A., Fagan, S., Ozomaro, B., Glisker, R., Ospina, L. H., & Kimhy, D. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116235 · Cited by 4 · see citing works
Associations between neurological soft signs, chronotype and sleep quality in schizophrenia
Kılıçaslan, E. E. (2020) · Dusunen Adam The Journal of Psychiatry and Neurological Sciences · doi:10.14744/dajpns.2020.00091 · Cited by 4 · see citing works
de Crom, S. A. M., de Haan, L., & Schirmbeck, F. N. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113728 · Cited by 4 · see citing works
Hamitouche, D., Zamorano, T., Barkat, Y., Parekh, D., Palaniyappan, L. K., Jalali, S., & Benrimoh, D. A. (2025) · JMIR Formative Research · doi:10.2196/81107 · Cited by 3 · see citing works
Sleep and schizophrenia spectrum
Gauld, C., & Hanin, C. (2026) · L Encéphale · doi:10.1016/j.encep.2026.02.005 · Cited by 3 · see citing works
Sleep disturbance as a marker of postpartum psychosis risk: a prospective actigraphy study
Petrosellini, C., Eriksson, S. H., Meyer, N., Antony, E., Protti, O., Donaldson, L., van Hees, V. T., Petrie, A., McQuillin, A., & Siassakos, D. M. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07017-6 · Cited by 3 · see citing works
Circadian rhythm disturbances and conversion to psychosis in ultra high-risk youth
Gonçalves, B., de Castro, J. P. M. V., Zanini, M. A., Bittencourt, L., Gadelha, A., da Cunha, G. R., Coelho, F. M. S., Tufik, S., Bressan, R. A., & Brietzke, E. M. (2016) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2015-1859 · Cited by 3 · see citing works
Self-citationUna revisión de los trastornos del sueño en la esquizofrenia
Anmella, G., Costanzo, M. C., Meneses, M. E. R., & Bernardo, M. (2017) · Psiquiatría Biológica · doi:10.1016/j.psiq.2017.05.005 · Cited by 3 · see citing works
Izuhara, M., Matsuda, H., Saito, A., Hayashida, M., Miura, S., Oh‐Nishi, A., Azis, I. A., Abdullah, R. A., Tsuchie, K., Araki, T., et al. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00260 · Cited by 3 · see citing works
Azzi, N. M., Fekih‐Romdhane, F., Khatib, S. E., Malaeb, D. N., Dabbous, M., Sakr, F., Hallit, S. R., Azzi, V., & Obeïd, S. (2024) · International Journal of Environmental Health Research · doi:10.1080/09603123.2024.2412144 · Cited by 2 · see citing works
Sleep Disorders in Schizophrenia. A Review of Literature
Anmella, G. (2017) · Theranostics of Brain Spine & Neural Disorders · doi:10.19080/tbsnd.2017.01.555575 · Cited by 1 · see citing works
The Effects of Sleep Quality on Theory of Mind
Erwin, J. A. (2016) · Digital Commons @ Butler University (Butler University) · Cited by 1 · see citing works
Ruíz-Grosso, P., Tomateo-Torvisco, D., Valencia, A., & Vega‐Dienstmaier, J. M. (2018) · Revista de Neuro-Psiquiatría · doi:10.20453/rnp.v81i1.3273
Effectively Assessing Sleep and Circadian Rhythms in Psychosis
Cosgrave, J., Klingaman, E. A., & Gehrman, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815012-2.00011-0
Cunha, G., Asevedo, E., Brietzke, E., Bressan, R., & Gadelha, A. (2019) · Handbook of Attenuated Psychosis Syndrome Across Cultures · doi:10.1007/978-3-030-17336-4_14
Self-citationBáthori, N., Moustafa, A. A., & Polner, B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820005-6.00010-4
Tikka, S. K., & Garg, S. (2022) · Springer eBooks · doi:10.1007/978-981-16-0123-1_20
Cirurgia bariátrica em pessoas com esquizofrenia
Ferreira, A. C. (2020) · doi:10.47749/t/unicamp.2020.1162032
Cognitive-Behavioral Therapy for Insomnia (CBT-I) for Schizophrenia: A Review
Chaurasia, N., Mishra, P., Malik, G., & Garg, S. (2023) · Journal of Mountain Research · doi:10.51220/jmr.v18i2.12
Miller, S., Ospina, L. H., Mullins, A. E., Parekh, A., Kam, K., Fowler, C., Varga, A. W., & Kimhy, D. (2025) · medRxiv · doi:10.1101/2025.08.18.25333917
Wang, Q., Hu, S., Qi, L., Wang, X., Jin, G., Wu, D., Wang, Y., & Ren, L. (2024) · Figshare · doi:10.6084/m9.figshare.24234300
Rogers, E. N., Gresswell, D. M., Durrant, S. J., & Hancoxt, L. (2026) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgag001
Postpartum Psychosis: could genetic vulnerability to insomnia or short sleep duration be protective?
Petrosellini, C., Eriksson, S. H., Meyer, N., Protti, O., Bass, N. J., Kuchenbaecker, K. B., Siassakos, D. M., & McQuillin, A. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03856-3
Interindividual Sleep Variability Across the Psychosis Spectrum
Aronica, R., Torous, J. B., Minichino, A., Mills, M., McGuire, P. K., & Oliver, D. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.24358
- Authors
- Zanini, M., Castro, J., Coelho, F. M., Bittencourt, L., Bressan, R. A., Tufik, S., & Brietzke, E.
- Affiliations
- Universidade Federal de São Paulo (BR)
- ORCID
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 37
- Issue
- 10
- Pages
- 2631-2637
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2038514511
- Cited by
- 69
- References
- 88
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Associacao Fundo de Incentivo a Pesquisa (AFIP)
- the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep abnormalities, schizophrenia, psychosis, prodromal psychosis, vulnerable populations, slow-wave sleep, REM sleep, sleep homeostasis, early diagnosis, risk prediction
- MeSH terms
- Humans, Psychotic Disorders, Risk Factors, Sleep Wake Disorders, Chronobiology Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
