Impairment of visuospatial memory is associated with decreased slow wave sleep in schizophrenia
Abstract
Cognitive impairments such as memory deficits and sleep disturbances are common clinical features of schizophrenia. Since sleep plays an important role in consolidation of memory, we hypothesize, that there is an interrelationship between distinct alterations in sleep and memory performance in schizophrenia. We studied 17 patients with schizophrenia on stable antipsychotic medication with amisulpride (age range 22-44 years; 7 women) and 17 healthy controls (matched for age, gender and educational level). Sleep was recorded and scored according to the standard criteria by Rechtschaffen and Kales. Immediately before polysomnography and the morning after we performed neuropsychological tasks including Rey-Osterrieth Complex Figure Test and a test for recall of spatial location for testing aspects of declarative memory and a mirror tracing skill for procedural memory. In comparison to healthy controls, the patients showed a significant increase in sleep onset latency and a significant decrease in sleep efficiency and amount of slow wave sleep (SWS). Furthermore, the patients' performance in recall of the Rey-figure and of spatial location the next morning was significantly impaired. These impairments in the tests for visuospatial memory were positively correlated with reduction in the amount of SWS and in sleep efficiency. These results point to a functional interrelationship between regulation of SWS and performance in visuospatial memory in schizophrenia. If these results of our pilot study hold true, they will allow the development of innovative treatment strategies for neuropsychological deficits in patients with schizophrenia.
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Several studies reported correlations between SWS or SWA and overnight retention of declarative memory and procedural motor skills.
“Several studies reported correlations between SWS or SWA and the overnight retention of declarative memory (55,58,464,1319) as well as procedural motor skills (581, 582).”
From About Sleep's Role in Memory (2013) · cites this paper as [464]
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- Authors
- Göder, R., Boigs, M., Braun, S., Friege, L., Fritzer, G., Aldenhoff, J. B., & Hinze-Selch, D.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- Corresponding author
- Göder, Robert
- ORCID
- Göder, Robert
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 38
- Issue
- 6
- Pages
- 591-599
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2172218099
- Cited by
- 109
- References
- 63
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 5
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sanofi
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- schizophrenia, visuospatial memory, slow-wave sleep, sleep efficiency, sleep latency, memory consolidation, declarative memory, procedural memory, mirror tracing, Rey-Osterrieth Complex Figure Test, amisulpride, antipsychotic drugs, cognitive impairment
- MeSH terms
- Amisulpride, Adult, Female, Humans, Male, Memory Disorders, Neuropsychological Tests, Schizophrenia, Sleep Wake Disorders, Space Perception, Sulpiride, Antipsychotic Agents, Visual Perception, Case-Control Studies
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