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Cited by 462

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Amplitude of low-frequency oscillations in schizophrenia: A resting state fMRI study

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Hoptman, Matthew J., Zuo, Xi-Nian, Butler, Pamela D., Javitt, Daniel C., D'Angelo, Debra, Mauro, Cristina J., Milham, Michael P.·2010·Schizophrenia Research

Abstract

Recently, a great deal of interest has arisen in resting state fMRI as a measure of tonic brain function in clinical populations. Most studies have focused on the examination of temporal correlation between resting state fMRI low-frequency oscillations (LFOs). Studies on the amplitudes of these low-frequency oscillations are rarely reported. Here, we used amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF; the relative amplitude that resides in the low frequencies) to examine the amplitude of LFO in schizophrenia. Twenty-six healthy controls and 29 patients with schizophrenia or schizoaffective disorder participated. Our findings show that patients showed reduced low-frequency amplitude in proportion to the total frequency band investigated (i.e., fALFF) in the lingual gyrus, left cuneus, left insula/superior temporal gyrus, and right caudate and increased fALFF in the medial prefrontal cortex and the right parahippocampal gyrus. ALFF was reduced in patients in the lingual gyrus, cuneus, and precuneus and increased in the left parahippocampal gyrus. These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed.

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Metadata

Authors
Hoptman, M. J., Zuo, X.-N., Butler, P. D., Javitt, D. C., D'Angelo, D., Mauro, C. J., & Milham, M. P.
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2010-03
Volume
117
Issue
1
Pages
13-20
ISSN
0920-9964 (ISSN-L)
OpenAlex
W2072481403
Cited by
462
References
70
FWCI
8.53
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Amplitude of low-frequency oscillations in schizophrenia: A resting state fMRI study. https://app.cochat.ai/papers/10.1016/j.schres.2009.09.030
The paper
Hoptman, M. J., Zuo, X.-N., Butler, P. D., Javitt, D. C., D'Angelo, D., Mauro, C. J., & Milham, M. P. (2010). Amplitude of low-frequency oscillations in schizophrenia: A resting state fMRI study. Schizophrenia Research. https://doi.org/10.1016/j.schres.2009.09.030

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