Evidence for excessive frontal evoked gamma oscillatory activity in schizophrenia during working memory
Abstract
Gamma (gamma) oscillations (30-50 Hz) elicited during working memory (WM) are altered in schizophrenia (SCZ). However, the nature of the relationship between evoked frontal oscillatory activity, WM performance and symptom severity has yet to be ascertained. This study had two objectives. First, to extend previous studies by examining delta, theta, alpha, beta, and gamma (delta, theta, alpha, beta, and gamma) oscillatory activities during the N-back task in SCZ patients compared to healthy subjects; second, to evaluate the relationship between oscillatory activities elicited during the N-back, performance, and clinical symptoms in SCZ patients. Patients with SCZ elicited excessive frontal gamma oscillatory activity that was most pronounced in the 3-back condition compared to healthy subjects. Reduced frontal beta activity at all WM loads was also observed in patients with SCZ compared to healthy subjects. Task performance was inversely correlated with negative symptoms but not with positive symptoms. Our findings suggest that evoked frontal oscillatory activities during WM are selectively altered in the gamma and beta frequency bands that may contribute to WM impairment in SCZ patients. These findings may provide important insights into the pathophysiology underlying WM deficits, its relationship to negative symptoms and may represent a potential neurobiological marker for cognitive enhancing strategies in SCZ.
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People with schizophrenia show altered gamma oscillations during a working memory task.
“Furthermore, individuals with schizophrenia have a lower density of excitatory synapses on PV-INs [12] and exhibit alterations in gamma oscillations during a working memory task [13].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [13]
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- Authors
- Barr, M. S., Farzan, F., Tran, L. C., Chen, R., Fitzgerald, P. B., & Daskalakis, Z. J.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- The Alfred Hospital (AU)
- Corresponding author
- Daskalakis, Z.J.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 121
- Issue
- 1-3
- Pages
- 146-152
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2103650934
- Cited by
- 125
- References
- 3
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 2 · 2020: 10 · 2019: 5 · 2018: 12 · 2017: 6 · 2016: 6 · 2015: 14 · 2014: 14 · 2013: 13 · 2012: 16
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP62917)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- schizophrenia, working memory
- MeSH terms
- Adult, Analysis of Variance, Biological Clocks, Brain Mapping, Electroencephalography, Female, Frontal Lobe, Humans, Male, Memory Disorders, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Photic Stimulation, Reaction Time, Schizophrenia, Schizophrenic Psychology, Spectrum Analysis, Antipsychotic Agents, Young Adult
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