Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

Gonzalez-Burgos, Guillermo; Cho, Raymond Y.; Lewis, David A.

doi:10.1016/j.biopsych.2015.03.010

Cited by 497Schizophrenia research and treatmentNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

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Gonzalez-Burgos, Guillermo, Cho, Raymond Y., Lewis, David A.·2015·Biological Psychiatry

DOI 10.1016/j.biopsych.2015.03.010PMC PMC4444373

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Abstract

Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available medications. Thus, understanding the neural basis of these deficits is crucial for the development of new therapeutic interventions. The types of cognitive processes affected in schizophrenia are thought to depend on the precisely timed transmission of information in cortical regions via synchronous oscillations at gamma band frequency. Here, we review 1) data from clinical studies suggesting that induction of frontal cortex gamma oscillations during tasks that engage cognitive or complex perceptual functions is attenuated in schizophrenia; 2) findings from basic neuroscience studies highlighting the features of parvalbumin-positive interneurons that are critical for gamma oscillation production; and 3) results from recent postmortem human brain studies providing additional molecular bases for parvalbumin-positive interneuron alterations in prefrontal cortical circuitry in schizophrenia.

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Parvalbumin- and perineuronal-net-mediated alterations are likely to contribute to dysfunction of the layer 3 parvalbumin-pyramidal cell local circuitry that generates gamma oscillations and thus to the neural basis for impairments in dorsolateral prefrontal cortex gamma oscillations seen during cognitive tasks in individuals with schizophrenia.
“Through a variety of mechanisms, PV and PNN-mediated alterations are likely to contribute to dysfunction of the layer 3 PV-PC local circuitry that generates γ-oscillations (Gonzalez-Burgos et al, 2015) and thus to the neural basis for the impairments in DLPFC γ-oscillations seen during cognitive tasks in individuals with schizophrenia (Uhlhaas and Singer, 2015).”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Gonzalez-Burgos et al, 2015

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Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs
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MEG gamma band activity in schizophrenia patients and healthy subjects in a mental arithmetic task and at rest
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Rapid Developmental Maturation of Neocortical FS Cell Intrinsic Excitability
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Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia
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Evidence for excessive frontal evoked gamma oscillatory activity in schizophrenia during working memory
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GABA abnormalities in schizophrenia: A methodological review of in vivo studies
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Disease-specific alterations in glutamatergic neurotransmission on inhibitory interneurons in the prefrontal cortex in schizophrenia
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Segregation of Axonal and Somatic Activity During Fast Network Oscillations
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Obligatory Role for the Immediate Early Gene NARP in Critical Period Plasticity
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State-dependent function of neocortical chandelier cells
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The saccadic spike artifact in MEG
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In Vivo Measurement of GABA Transmission in Healthy Subjects and Schizophrenia Patients
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Development of calcium‐permeable AMPA receptors and their correlation with NMDA receptors in fast‐spiking interneurons of rat prefrontal cortex
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GAD67 Deficiency in Parvalbumin Interneurons Produces Deficits in Inhibitory Transmission and Network Disinhibition in Mouse Prefrontal Cortex
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Developmental origin dictates interneuron AMPA and NMDA receptor subunit composition and plasticity
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Cell Type-Specific Long-Term Plasticity at Glutamatergic Synapses onto Hippocampal Interneurons Expressing either Parvalbumin or CB 1 Cannabinoid Receptor
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Kv3.1-containing K channels are reduced in untreated schizophrenia and normalized with antipsychotic drugs
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Target-Specific Properties of Thalamocortical Synapses onto Layer 4 of Mouse Primary Visual Cortex
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Resting GABA and glutamate concentrations do not predict visual gamma frequency or amplitude
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Lower Expression of Glutamic Acid Decarboxylase 67 in the Prefrontal Cortex in Schizophrenia: Contribution of Altered Regulation by Zif268
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Temporal Dynamics of Parvalbumin-Expressing Axo-axonic and Basket Cells in the Rat Medial Prefrontal CortexIn Vivo
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Heteromeric Assembly of Kv2.1 with Kv9.3: Effect on the State Dependence of Inactivation
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Pyramidal Neuron Local Axon Terminals in Monkey Prefrontal Cortex: Differential Targeting of Subclasses of GABA Neurons
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A combined analysis of microarray gene expression studies of the human prefrontal cortex identifies genes implicated in schizophrenia
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GABAergic and Pyramidal Neurons of Deep Cortical Layers Directly Receive and Differently Integrate Callosal Input
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Differential Activity-Dependent, Homeostatic Plasticity of Two Neocortical Inhibitory Circuits
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Metabotropic Glutamate Receptor Type 5-Dependent Long-Term Potentiation of Excitatory Synapses on Fast-Spiking GABAergic Neurons in Mouse Visual Cortex
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SDF1α/CXCR4 Signaling, via ERKs and the Transcription Factor Egr1, Induces Expression of a 67-kDa Form of Glutamic Acid Decarboxylase in Embryonic Hippocampal Neurons
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Functional maturation of GABA synapses during postnatal development of the monkey dorsolateral prefrontal cortex
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Mechanisms of GABAergic Homeostatic Plasticity
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Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia
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Fluorescence measurements reveal stoichiometry of K + channels formed by modulatory and delayed rectifier α-subunits
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Ketamine Administration During the Second Postnatal Week Alters Synaptic Properties of Fast-Spiking Interneurons in the Medial Prefrontal Cortex of Adult Mice
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Structure and the Promoter Region of the Mouse Gene Encoding the 67-kD Form of Glutamic Acid Decarboxylase
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Behavioral consequences of GABAergic neuronal diversity
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[11C]flumazenil Binding Is Increased in a Dose-Dependent Manner with Tiagabine-Induced Elevations in GABA Levels
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Interneurons Provide Circuit-Specific Depolarization and Hyperpolarization
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Genetic Association of ErbB4 and Human Cortical GABA LevelsIn Vivo
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Modulation of behavioral networks by selective interneuronal inactivation
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Selective Reduction of AMPA Currents onto Hippocampal Interneurons Impairs Network Oscillatory Activity
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Computational study of NMDA conductance and cortical oscillations in schizophrenia
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Selective Expression of KCNS3 Potassium Channel α-Subunit in Parvalbumin-Containing GABA Neurons in the Human Prefrontal Cortex
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Cell-type specific function of GABAergic neurons in layers 2 and 3 of mouse barrel cortex
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Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
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Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
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Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice
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Authors: Gonzalez-Burgos, G., Cho, R. Y., & Lewis, D. A.
Affiliations: The University of Texas Health Science Center at Houston (US)
University of Pittsburgh (US)
Corresponding author: Lewis, David A.
ORCID: Cho, Raymond Y.
Lewis, David A.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2015-06
Volume: 77
Issue: 12
Pages: 1031-1040
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2015.03.010
PMC: PMC4444373
OpenAlex: W1989973456
Cited by: 497
References: 149
Citations by year: 2026: 22 · 2025: 31 · 2024: 51 · 2023: 46 · 2022: 32 · 2021: 63 · 2020: 56 · 2019: 40 · 2018: 47 · 2017: 50 · 2016: 42 · 2015: 17
FWCI: 7.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (MH043784, MH103204)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: schizophrenia, cortical oscillations, gamma oscillations, parvalbumin interneurons, prefrontal cortex, cognitive impairment, neuronal synchronization, postmortem brain, cortical circuits
MeSH terms: Animals, Cerebral Cortex, Cortical Synchronization, Humans, Models, Neurological, Nerve Net, Neural Inhibition, Parvalbumins, Schizophrenia, Schizophrenic Psychology, Brain Waves, GABAergic Neurons, Gamma Rhythm

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Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

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