Characteristics of the MATRICS Consensus Cognitive Battery in a 29-site antipsychotic schizophrenia clinical trial

Keefe, Richard S.E.; Fox, Kolleen Hurley; Harvey, Philip D.; Cucchiaro, Josephine; Siu, Cynthia; Loebel, Antony

doi:10.1016/j.schres.2010.09.015

Cited by 237Schizophrenia research and treatmentPsychological Testing and AssessmentDementia and Cognitive Impairment Research

Characteristics of the MATRICS Consensus Cognitive Battery in a 29-site antipsychotic schizophrenia clinical trial

Keefe, Richard S.E., Fox, Kolleen Hurley, Harvey, Philip D., Cucchiaro, Josephine, Siu, Cynthia, Loebel, Antony·2011·Schizophrenia Research

DOI 10.1016/j.schres.2010.09.015

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Abstract

Objective The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Project produced a battery of tests, the MATRICS Consensus Cognitive Battery (MCCB), designed to assess cognitive treatment effects in clinical trials of patients with schizophrenia. In validation studies, the MCCB demonstrated excellent reliability, minimal practice effects and significant correlations with measures of functional capacity. This study addresses whether the MCCB demonstrates these favorable characteristics when administered in the context of the type of large multi-site industry trial for which it was designed.Methods In a clinical trial comparing risperidone and lurasidone, 323 clinically-stable outpatients with schizophrenia at 29 sites were assessed with MCCB at screening and a median of 15days later at baseline. A measure of functional capacity, the UCSD Performance-based Skills Assessment-Brief (UPSA-B) was administered at baseline.Results All 323 (100%) patients had sufficient data for computing a composite score according to the MCCB criteria. The test-retest reliability of the MCCB composite score was excellent (ICC=0.88). The severity of cognitive impairment was T=24.7 (SD=12.1) at screening and T=26.7 (SD=12.4) at baseline. The MCCB composite score demonstrated a large correlation with the UPSA-B composite score (r=.60, df=304, p<.001). The practice effect on the composite score was small (z=0.18).Discussion In the context of a 29-site antipsychotic trial in stable outpatients with schizophrenia, the MCCB is sensitive to cognitive deficits in all domains, demonstrates excellent test-retest reliability and small practice effects, and is strongly correlated with a leading measure of functional capacity.

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Early results suggest that good psychometric characteristics of the cognitive outcome measure are possible in large multisite studies if sufficient care is given to training and data quality.
“Early results suggest that good psychometric characteristics of the cognitive outcome measure are possible in large multisite studies if sufficient care is given to training and data quality.21”
From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [21]
These favorable psychometric properties of the MCCB have also been observed in the context of a large multisite industry trial for which it was designed.
“These favorable psychometric properties have also been observed in the context of a large multisite industry trial for which it was designed.21”
From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [21]

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Authors: Keefe, R. S. E., Fox, K. H., Harvey, P. D., Cucchiaro, J., Siu, C., & Loebel, A.
Affiliations: Duke University (US)
Verasci (United States) (US)
University of Miami (US)
Sunovion (United States) (US)
Corresponding author: Keefe, Richard S.E.
ORCID: Keefe, Richard S.E.
Harvey, Philip D.
Loebel, Antony
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2011-02
Volume: 125
Issue: 2-3
Pages: 161-168
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2010.09.015
OpenAlex: W2169310695
Cited by: 237
References: 17
Citations by year: 2026: 14 · 2025: 25 · 2024: 15 · 2023: 11 · 2022: 15 · 2021: 9 · 2020: 12 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 13 · 2015: 16 · 2014: 22 · 2013: 20 · 2012: 14
FWCI: 10.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Funders: GlaxoSmithKline
CHDI Foundation
H. Lundbeck A/S
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: MATRICS Consensus Cognitive Battery, schizophrenia
MeSH terms: Lurasidone Hydrochloride, Adult, Cognition Disorders, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychometrics, Schizophrenia, Schizophrenic Psychology, Thiazoles, Antipsychotic Agents, Reproducibility of Results, Risperidone, Isoindoles

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Characteristics of the MATRICS Consensus Cognitive Battery in a 29-site antipsychotic schizophrenia clinical trial

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