Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria
Abstract
To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference. The goals of the meeting were to 1) identify the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literature and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory, reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability, high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia.
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To avoid arbitrary definitions of cognitive domains, the authors based their seven domains on the guidelines of the two most commonly used cognitive test batteries.
“To avoid that the definition of cognitive domains would be arbitrary, we based our seven domains on the guidelines of the two most commonly used cognitive test batteries (Green et al., 2004; Litvan et al., 2012).”
From Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis (2020) · cites this paper as Green et al., 2004
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- Authors
- Green, M. F., Nuechterlein, K. H., Gold, J. M., Barch, D. M., Cohen, J., Essock, S., Fenton, W. S., Frese, F., Goldberg, T. E., Heaton, R. K., Keefe, R. S. E., Kern, R. S., Kraemer, H., Stover, E., Weinberger, D. R., Zalcman, S., & Marder, S. R.
- Affiliations
- University of California, Los Angeles (US)
- University of Maryland, Baltimore (US)
- Washington University in St. Louis (US)
- Princeton University (US)
- Icahn School of Medicine at Mount Sinai (US)
- National Institutes of Health (US)
- Northeast Ohio Medical University (US)
- University of California San Diego (US)
- Duke University (US)
- Stanford University (US)
- Corresponding author
- Green, Michael F.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 56
- Issue
- 5
- Pages
- 301-307
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1983805722
- Cited by
- 919
- References
- 2
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 36 · 2023: 25 · 2022: 38 · 2021: 27 · 2020: 39 · 2019: 49 · 2018: 45 · 2017: 42 · 2016: 49 · 2015: 58 · 2014: 59 · 2013: 69 · 2012: 46
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01mh022006-001)
- National Institute of Mental Health (MH22006)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- schizophrenia, cognitive impairment, cognitive battery, cognitive domain, test selection criteria, working memory, attention, verbal learning and memory, visual learning and memory, reasoning and problem solving, processing speed, social cognition, test-retest reliability, clinical trial outcome measures, consensus conference
- MeSH terms
- Clinical Trials as Topic, Cognition Disorders, Consensus Statements as Topic, Humans, National Institute of Mental Health (U.S.), Neuropsychological Tests, Research Design, Schizophrenia, United States, Diagnostic and Statistical Manual of Mental Disorders
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