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A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosis

Addington, Jean, Epstein, Irvin, Liu, Lu, French, Paul, Boydell, Katherine M., Zipursky, Robert B.·2011·Schizophrenia Research

DOI 10.1016/j.schres.2010.10.015

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Abstract

Background There has been increasing interest in early detection during the prodromal phase of a psychotic disorder. To date a few treatment studies have been published with some promising results for both pharmacological treatments, using second generation antipsychotics, and psychological interventions, mainly cognitive behavioral therapy. The purpose of this study was to determine first if cognitive behavioral therapy (CBT) was more effective in reducing the rates of conversion compared to a supportive therapy and secondly whether those who received CBT had improved symptoms compared to those who received supportive therapy.Method Fifty-one individuals at clinical high risk of developing psychosis were randomized to CBT or a supportive therapy for up to 6 months. The sample was assessed at 6, 12 and 18 months post baseline on attenuated positive symptoms, negative symptoms, depression, anxiety and social functioning.Results Conversions to psychosis only occurred in the group who received supportive therapy although the difference was not significant. Both groups improved in attenuated positive symptoms, depression and anxiety and neither improved in social functioning and negative symptoms. There were no differences between the two treatment groups. However, the improvement in attenuated positive symptoms was more rapid for the CBT group.Conclusions There are limitations of this trial and potential explanations for the lack of differences. However, both the results of this study and the possible explanations have significant implications for early detection and intervention in the pre-psychotic phase and for designing future treatments.

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Authors: Addington, J., Epstein, I., Liu, L., French, P., Boydell, K. M., & Zipursky, R. B.
Affiliations: Centre for Addiction and Mental Health (CA)
University of Calgary (CA)
Greater Manchester Mental Health NHS Foundation Trust (GB)
University of Toronto (CA)
McMaster University (CA)
Corresponding author: Addington, Jean
ORCID: Addington, Jean
Liu, Lu
French, Paul
Boydell, Katherine M.
Zipursky, Robert B.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2011-01
Volume: 125
Issue: 1
Pages: 54-61
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2010.10.015
OpenAlex: W2053821113
Cited by: 226
References: 30
Citations by year: 2026: 3 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 21 · 2019: 19 · 2018: 11 · 2017: 8 · 2016: 17 · 2015: 23 · 2014: 25 · 2013: 26 · 2012: 25
FWCI: 12.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords: cognitive behavioral therapy, clinical high risk for psychosis
MeSH terms: Adolescent, Adult, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Psychiatric Status Rating Scales, Psychotic Disorders, Time Factors, Reproducibility of Results, Cognitive Behavioral Therapy, Treatment Outcome, Young Adult

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A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosis

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