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A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosis
Abstract
Background There has been increasing interest in early detection during the prodromal phase of a psychotic disorder. To date a few treatment studies have been published with some promising results for both pharmacological treatments, using second generation antipsychotics, and psychological interventions, mainly cognitive behavioral therapy. The purpose of this study was to determine first if cognitive behavioral therapy (CBT) was more effective in reducing the rates of conversion compared to a supportive therapy and secondly whether those who received CBT had improved symptoms compared to those who received supportive therapy.Method Fifty-one individuals at clinical high risk of developing psychosis were randomized to CBT or a supportive therapy for up to 6 months. The sample was assessed at 6, 12 and 18 months post baseline on attenuated positive symptoms, negative symptoms, depression, anxiety and social functioning.Results Conversions to psychosis only occurred in the group who received supportive therapy although the difference was not significant. Both groups improved in attenuated positive symptoms, depression and anxiety and neither improved in social functioning and negative symptoms. There were no differences between the two treatment groups. However, the improvement in attenuated positive symptoms was more rapid for the CBT group.Conclusions There are limitations of this trial and potential explanations for the lack of differences. However, both the results of this study and the possible explanations have significant implications for early detection and intervention in the pre-psychotic phase and for designing future treatments.
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“Only two studies had an overall low risk of bias 33,79 ; five had unclear risk [72][73][74][75][76] , and nine had high risk 30,31,36,37,39,41,77,78,81 .”
From Lack of evidence to favor specific preventive interventions in psychosis: a network meta‐analysis (2018) · cites this paper as [30]
Citations
Cites
Factor structure of the working alliance inventory
Tracey, T. J., & Kokotovic, A. M. (1989) · Psychological Assessment: A Journal of Consulting and Clinical Psychology · doi:10.1037/1040-3590.1.3.207 · Cited by 1,501 · cited 2×
“The three sub-scores from the WAI-SF (therapeutic bond, client and therapist agreement on goals, client and therapist agreement on tasks) can range from7 to 28.”
MethodCannon, T. D., Cadenhead, K., Cornblatt, B., Woods, S. W., Addington, J., Walker, E., Seidman, L. J., Perkins, D., Tsuang, M., McGlashan, T., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.3 · Cited by 1,269
Self-citationAssessing Depression in Schizophrenia: The Calgary Depression Scale
Addington, D. E., Addington, J., & Maticka‐Tyndale, E. (1993) · The British Journal of Psychiatry · doi:10.1192/s0007125000292581 · Cited by 1,177
Self-citationBirchwood, M., Smith, J., Cochrane, R., Wetton, S., & Copestake, S. (1990) · British Journal of Psychiatry · doi:10.1192/bjp.157.6.853 · Cited by 1,157
Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group
Yung, A. R., Phillips, L. J., Yuen, H. P., Francey, S. M., McFarlane, C. A., Hallgren, M., & McGorry, P. D. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00167-6 · Cited by 1,136
McGorry, P. D., Yung, A. R., Phillips, L. J., Yuen, H. P., Francey, S., Cosgrave, E. M., Germano, D., Bravin, J., McDonald, T., Blair, A., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.10.921 · Cited by 1,056
McGorry, P. D., Hickie, I. B., Yung, A. R., Pantelis, C., & Jackson, H. J. (2006) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2006.01860.x · Cited by 919
Amminger, G. P., Schäfer, M. R., Papageorgiou, K., Klier, C. M., Cotton, S. M., Harrigan, S. M., Mackinnon, A., McGorry, P. D., & Berger, G. E. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.192 · Cited by 896
Miller, T. J., McGlashan, T. H., Rosen, J. L., Somjee, L., Markovich, P. J., Stein, K., & Woods, S. W. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.863 · Cited by 872
Monitoring and Care of Young People at Incipient Risk of Psychosis
Yung, A. R., McGorry, P. D., McFarlane, C. A., Jackson, H. J., Patton, G. C., & Rakkar, A. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.2.283 · Cited by 773
Morrison, A. P., French, P., Walford, L., Lewis, S. W., Kilcommons, A., Green, J., Parker, S., & Bentall, R. P. (2004) · British Journal of Psychiatry · doi:10.1192/bjp.185.4.291 · Cited by 740
Self-citationRuhrmann, S., Schultze-Lutter, F., Salokangas, R. K. R., Heinimaa, M., Linszen, D., Dingemans, P., Birchwood, M., Patterson, P., Juckel, G., Heinz, A., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.206 · Cited by 632
McGlashan, T. H., Zipursky, R. B., Perkins, D., Addington, J., Miller, T., Woods, S. W., A. Hawkins, K., E. Hoffman, R., Preda, A., Epstein, I., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.5.790 · Cited by 556
Self-citationDeclining Transition Rate in Ultra High Risk (Prodromal) Services: Dilution or Reduction of Risk?
Yung, A. R., Yuen, H. P., Berger, G. E., Francey, S. M., Hung, T.-C., Nelson, B., Phillips, L., & McGorry, P. D. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm015 · Cited by 422
Lewis, S. W., Tarrier, N., Haddock, G., Bentall, R. P., Kinderman, P., Kingdon, D., Siddle, R., Drake, R., Everitt, J., Leadley, K., et al. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.181.43.s91 · Cited by 374
The Cognitive Therapy Scale: Psychometric properties.
Vallis, M., Shaw, B. F., & Dobson, K. S. (1986) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.54.3.381 · Cited by 331
The Cognitive Therapy Scale: Psychometric properties.
Vallis, T. M., Shaw, B. F., & Dobson, K. S. (1986) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.54.3.381 · Cited by 331
Garety, P. A., Fowler, D. G., Freeman, D., Bebbington, P., Dunn, G., & Kuipers, E. (2008) · British Journal of Psychiatry · doi:10.1192/bjp.bp.107.043570 · Cited by 296
Cognitive–behavioural therapy in first-episode and early schizophrenia
Tarrier, N., Lewis, S. W., Haddock, G., Bentall, R. P., Drake, R., Kinderman, P., Kingdon, D., Siddle, R., Everitt, J., Leadley, K., et al. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.3.231 · Cited by 269
Morrison, A. P., French, P., Parker, S., Roberts, M., Stevens, H., Bentall, R. P., & Lewis, S. W. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl042 · Cited by 228
Self-citationMcGlashan, T. H., Zipursky, R. B., Perkins, D. O., Addington, D. E., Miller, T. J., Woods, S. W., Hawkins, K. A., Hoffman, R., Lindborg, S. R., Tohen, M. F., et al. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00439-5 · Cited by 213
Self-citationMiller, T. J., Zipursky, R. B., Perkins, D., Addington, J., Woods, S. W., Hawkins, K. A., Hoffman, R., Preda, A., Epstein, I., Addington, D., et al. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00440-1 · Cited by 150
Self-citationReliability of a measure of the quality of cognitive therapy
Dobson, K. S., Shaw, B. F., & Vallis, M. (1985) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.1985.tb00662.x · Cited by 125
French, P., & Morrison, A. P. (2004) · Thammasat University Digital Collections · doi:10.1002/9780470713259 · Cited by 97
Self-citationMore harm than good: The case against using antipsychotic drugs to prevent severe mental illness
Bentall, R. P., & Morrison, A. P. (2002) · Journal of Mental Health · doi:10.1080/09638230020023723 · Cited by 97
Phillips, L., Nelson, B., Yuen, H. P., Francey, S. M., Simmons, M. B., Stanford, C., Ross, M., Kelly, D., Baker, K., Conus, P., et al. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670903107625 · Cited by 78
Olivares, J., López, L. J. G., & Montesinos, M. D. H. (2001) · Journal of Psychoeducational Assessment · doi:10.1177/073428290101900105 · Cited by 70
Sample Size and Power in Psychiatric Research *
Streiner, D. L. (1990) · The Canadian Journal of Psychiatry · doi:10.1177/070674379003500712 · Cited by 58
Early detection of psychosis: finding those at clinical high risk
Addington, J., Epstein, I., Reynolds, A., Furimsky, I., Rudy, L., Mancini, B., McMillan, S., Kirsopp, D., & Zipursky, R. B. (2008) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2008.00078.x · Cited by 39
Self-citationFrench, P., Shryane, N. M., Bentall, R. P., Lewis, S. W., & Morrison, A. P. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.191.51.s82 · Cited by 36
Self-citation
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The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review
Fusar-Poli, P., Borgwardt, S., Bechdolf, A., Addington, J., Riecher-Rössler, A., Schultze-Lutter, F., Keshavan, M., Wood, S., Ruhrmann, S., Seidman, L. J., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.269 · Cited by 1,483
Self-citationEPA guidance on the early intervention in clinical high risk states of psychoses
Schmidt, S. J., Schultze-Lutter, F., Schimmelmann, B. G., Maric, N. P., Salokangas, R. K. R., Riecher-Rössler, A., van der Gaag, M., Meneghelli, A., Nordentoft, M., Marshall, M., et al. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.01.013 · Cited by 585
Altering the course of schizophrenia: progress and perspectives
Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., et al. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.28 · Cited by 516
Early interventions to prevent psychosis: systematic review and meta-analysis
Stafford, M. R., Jackson, H., Mayo-Wilson, E., Morrison, A. P., & Kendall, T. (2013) · BMJ · doi:10.1136/bmj.f185 · Cited by 456
EPA guidance on the early detection of clinical high risk states of psychoses
Schultze‐Lutter, F., Michel, C., Schmidt, S. J., SCHIMMELMANN, B. G., Marić, N. P., Salokangas, R. K. R., Riecher‐Rössler, A., van der Gaag, M., Nordentoft, M., Raballo, A., et al. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.01.010 · Cited by 405
Metadata
- Authors
- Addington, J., Epstein, I., Liu, L., French, P., Boydell, K. M., & Zipursky, R. B.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- University of Calgary (CA)
- Greater Manchester Mental Health NHS Foundation Trust (GB)
- University of Toronto (CA)
- McMaster University (CA)
- Corresponding author
- Addington, Jean
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 125
- Issue
- 1
- Pages
- 54-61
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2053821113
- Cited by
- 226
- References
- 30
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 21 · 2019: 19 · 2018: 11 · 2017: 8 · 2016: 17 · 2015: 23 · 2014: 25 · 2013: 26 · 2012: 25
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- cognitive behavioral therapy, clinical high risk for psychosis
- MeSH terms
- Adolescent, Adult, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Psychiatric Status Rating Scales, Psychotic Disorders, Time Factors, Reproducibility of Results, Cognitive Behavioral Therapy, Treatment Outcome, Young Adult
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