Cognitive therapy for the prevention of psychosis in people at ultra-high risk: Randomised controlled trial
Open accessAbstract
Background: Advances in the ability to identify people at high risk of developing psychosis have generated interest in the possibility of preventing psychosis. Aims: To evaluate the efficacy of cognitive therapy for the prevention of transition to psychosis. Method: A randomised controlled trial compared cognitive therapy with treatment as usual in 58 patients at ultra-high risk of developing a first episode of psychosis. Therapy was provided over 6 months, and all patients were monitored on a monthly basis for 12 months. Results: Logistic regression demonstrated that cognitive therapy significantly reduced the likelihood of making progression to psychosis as defined on the Positive and Negative Syndrome Scale over 12 months. In addition, it significantly reduced the likelihood of being prescribed antipsychotic medication and of meeting criteria for a DSM – IV diagnosis of a psychotic disorder. Analysis of covariance showed that the intervention also significantly improved positive symptoms of psychosis in this population over the 12-month period. Conclusions: Cognitive therapy appears to be an acceptable and efficacious intervention for people at high risk of developing psychosis.
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Use of good emotion regulation strategies leads to a decrease in the likelihood of developing psychotic symptoms and prescribing medication in high-risk individuals.
“It would also lead to a decrease in the likelihood of developing psychotic symptoms and prescribing medication in “high-risk” individuals (34)”
From Mobile intervention for individuals with psychosis, dual disorders, and their common comorbidities: A literature review (2019) · cites this paper as [34]
The Logistic regression section (page unavailable) reports that cognitive therapy significantly reduced progression to psychosis and the likelihood of being prescribed antipsychotic medication in high-risk individuals. The Study design and intervention section describes cognitive therapy, not a test of “good emotion regulation strategies”; attributing those outcomes specifically to such strategies goes beyond the paper. (LLM, conf=0.88)
Experimental — accuracy not yet measuredOnly two included studies had an overall low risk of bias; five had unclear risk and nine had high risk.
“Only two studies had an overall low risk of bias 33,79 ; five had unclear risk [72][73][74][75][76] , and nine had high risk 30,31,36,37,39,41,77,78,81 .”
From Lack of evidence to favor specific preventive interventions in psychosis: a network meta‐analysis (2018) · cites this paper as [36]
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- Authors
- Morrison, A. P., French, P., Walford, L., Lewis, S. W., Kilcommons, A., Green, J., Parker, S., & Bentall, R. P.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Morrison, Anthony P.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2004-10
- Volume
- 185
- Issue
- 4
- Pages
- 291-297
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2107878018
- Cited by
- 740
- References
- 34
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 25 · 2020: 21 · 2019: 25 · 2018: 19 · 2017: 20 · 2016: 23 · 2015: 34 · 2014: 55 · 2013: 51 · 2012: 63
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- cognitive therapy, psychosis prevention, clinical high risk for psychosis, first-episode psychosis, transition to psychosis, antipsychotic drugs, usual care
- MeSH terms
- Adolescent, Adult, Female, Humans, Male, Psychotic Disorders, Risk Factors, Cognitive Behavioral Therapy, Treatment Outcome
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